【摘要】：目的:調(diào)查成人肺動(dòng)脈高壓(pulmonary hypertension,PH)患者的人口學(xué)特征和不同病因之間的構(gòu)成比。方法:回顧性調(diào)查2010年1月至2014年12月中南大學(xué)湘雅二醫(yī)院經(jīng)臨床診斷或經(jīng)胸多普勒超聲、右心導(dǎo)管檢查診斷為PH的2 508例成人住院患者,收集其臨床資料,包括研究對(duì)象的性別、年齡、原發(fā)病等,并進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:本次調(diào)查中PH患者人數(shù)逐年上升,患者年齡為47(18~93)歲;男性933例(37.20%),男:女約為1:1.69(P0.05)。其中,第I類PH(動(dòng)脈型PH)與第II類PH(左心疾病相關(guān)的PH)以女性多見(70%),第III類(呼吸系統(tǒng)疾病或缺氧相關(guān)性PH)以男性多見(74.5%)。在本次調(diào)查中,第I類PH 896例(35.73%)、第II類PH 1163例(46.37%)、第III類PH 411例(16.39%)、第IV類PH(慢性血栓性PH)32例(1.27%)、第V類PH(原因不明或多種因素所致PH)6例(0.24%)。發(fā)病例數(shù)居前7位的PH原發(fā)病依次為風(fēng)濕性心臟病(1 090例,43.48%)、先天性心臟病(692例,27.60%)、慢性阻塞性肺疾病(358例,14.28%)、結(jié)締組織相關(guān)性疾病(156例,6.22%)、瓣膜性心臟病(66例,2.63%)、特發(fā)性PH(46例,1.83%)、肺栓塞(27例,1.08%)。結(jié)論:在本次調(diào)查中成人PH發(fā)病的高峰年齡階段是41~50歲,其中以女性多見,且第I類及第II類PH以女性多見,第III類PH以男性多見;風(fēng)濕性心臟病及先天性心臟病是目前中國(guó)PH最常見的病因;慢性阻塞性肺疾病是第III類PH最常見病因,且此類患者年齡較大。
[Abstract]:Objective: to investigate the demographic characteristics of adult patients with pulmonary hypertension (pulmonary hypertension,PH) and the ratio of different etiological factors. Methods: from January 2010 to December 2014, 2 508 adult inpatients with PH diagnosed by clinical diagnosis or transthoracic Doppler ultrasound and right cardiac catheterization were investigated retrospectively, and their clinical data were collected. Including sex, age, primary disease and so on, and carries on the statistical analysis. Results: the number of patients with PH increased year by year, the age of the patients was 47 (1893) years, 933 cases (37.20%) of males and 1: 1.69 (P0.05) of males and females. Among them, type I PH (arterial type PH) and II class PH (PH associated with left ventricular disease) were more common in females (70%), and III (respiratory diseases or hypoxic associated PH) were more common in males (74.5%). There were 896 cases (35.73%) of type I PH, 1163 cases (46.37%) of II PH, 411 cases (16.39%) of III PH, 32 cases (1.27%) of IV PH (chronic thrombotic PH) and 6 cases (0.24%) of type V PH (PH caused by unknown or multiple factors). Rheumatic heart disease (1,090 cases, 43.48%), congenital heart disease (692 cases, 27.60%), chronic obstructive pulmonary disease (358 cases, 14.28%), connective tissue related disease (156 cases, 6.22%), valvular heart disease (66 cases, 2.63%), idiopathic heart disease (Idiopathic) were the first 7 cases of PH. PH (46 cases, 1.83%), pulmonary embolism (27 cases, 1.08%). Conclusion: in this investigation, the peak age of adult PH is 41 to 50 years old, and most of them are female, type I and II PH are female, and III PH is male. Rheumatic heart disease and congenital heart disease are the most common etiology of PH in China at present, chronic obstructive pulmonary disease is the most common cause of III PH, and these patients are older.
【作者單位】： 中南大學(xué)湘雅二醫(yī)院呼吸內(nèi)科湖南省循證醫(yī)學(xué)研究中心;
【基金】：國(guó)家科技支撐計(jì)劃(2013BAI09B104) 中南大學(xué)碩士生自主探索創(chuàng)新項(xiàng)目(2015zzts307)~~
【分類號(hào)】：R544.1

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