【摘要】：目的探討中年高血壓患者發(fā)生阿司匹林抵抗的危險(xiǎn)因素。方法應(yīng)用血栓彈力圖測定2012年5月至2015年4月在新鄉(xiāng)醫(yī)學(xué)院第三附屬醫(yī)院就診的中年高血壓患者177例,根據(jù)是否發(fā)生阿司匹林抵抗分為阿司匹林抵抗組和阿司匹林敏感組,比較2組患者的一般臨床資料。根據(jù)患者血壓控制水平分為血壓達(dá)標(biāo)組(收縮壓140 mm Hg,舒張壓90 mm Hg,1 mm Hg=0.133 k Pa)和血壓不達(dá)標(biāo)組(收縮壓≥140 mm Hg或舒張壓≥90 mm Hg),比較2組患者阿司匹林抵抗發(fā)生率情況,并對(duì)中年高血壓患者發(fā)生阿司匹林抵抗的危險(xiǎn)因素進(jìn)行l(wèi)ogistic回歸分析。結(jié)果中年高血壓患者177例中阿司匹林抵抗發(fā)生率為21.5%(38/177)。血壓達(dá)標(biāo)組患者阿司匹林抵抗發(fā)生率為11.8%(10/85),血壓不達(dá)標(biāo)組患者阿司匹林抵抗發(fā)生率為30.4%(28/92),血壓不達(dá)標(biāo)組患者阿司匹林抵抗發(fā)生率顯著高于血壓達(dá)標(biāo)組(χ~2=8.978,P0.05)。阿司匹林抵抗組患者體質(zhì)量、空腹血糖均顯著高于阿司匹林敏感組(P0.05);阿司匹林抵抗組較阿司匹林敏感組女性比例高(P0.05);logistic回歸分析顯示,空腹血糖、女性為阿司匹林抵抗的獨(dú)立危險(xiǎn)因素(P0.05)。結(jié)論中年高血壓患者出現(xiàn)阿司匹林抵抗時(shí),有較多的女性患者,阿司匹林抵抗的發(fā)生與患者空腹血糖和血壓控制相關(guān)。
[Abstract]:Objective to investigate the risk factors of aspirin resistance in middle aged patients with hypertension. Methods from May 2012 to April 2015, 177 middle-aged patients with hypertension were examined by thromboelastography in the third affiliated Hospital of Xinxiang Medical College. According to whether aspirin resistance occurred, 177 patients were divided into aspirin resistance group and aspirin sensitive group. The general clinical data of the two groups were compared. Patients were divided into two groups according to their blood pressure control level (SBP 140 mm Hg, diastolic blood pressure 90 mm Hg,1 mm Hg=0.133 k Pa) and blood pressure substandard group (systolic blood pressure 鈮，

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