冠心病合并特殊臨床情況的相關(guān)研究
發(fā)布時(shí)間:2018-10-12 16:38
【摘要】:目的分析急性心肌梗死(acute myocardial infarction, AMI)合并急性肺栓塞(acute pulmonary embolism, APE)的臨床參數(shù)和長期隨訪結(jié)果,討論該病發(fā)生的危險(xiǎn)因素,評價(jià)抗栓藥物的療效及患者預(yù)后。方法回顧性分析2004年3月至2014年5月在阜外醫(yī)院確診的AMI合并APE的34例患者的臨床參數(shù),對其進(jìn)行電話隨訪,并行Kaplan-Meier分析。結(jié)果本組患者年齡≥60歲、高血壓、糖尿病、高脂血癥、冠心病史、長期臥床的比例較高,臨床表現(xiàn)以胸悶、呼吸困難、胸痛、大汗為主,臨床體征以肺部濕羅音為主,主要通過肺動(dòng)脈CT增強(qiáng)掃描確診。阿司匹林+氯吡格雷+華法林(三聯(lián)抗栓)組出血率較高,但均為非致命性山血,無血栓事件發(fā)生,與其他組相比相對安全、有效;颊呖偹劳雎蕿20.6%,較AMI或APE高。結(jié)論AMI合并APE臨床情況復(fù)雜,臨床預(yù)后差,胸悶、胸痛、呼吸困難、大汗癥狀突出,主要通過肺動(dòng)脈CT增強(qiáng)掃描明確診斷,三聯(lián)抗栓治療是相對安全有效的。目的評價(jià)75歲及以.上老年患者在經(jīng)皮冠狀動(dòng)脈介入治療(PCI)術(shù)后遠(yuǎn)期預(yù)后是否存在性別差異。方法連續(xù)入選2004-04至2010-11期間在我院行PCI的29 211例冠心病患者,分為:≥75歲女性組(521例)、75歲女性組(5 666例)、≥75歲男性組(1 098例)和75歲男性組(21 926例)。比較各組患者PCI術(shù)后住院期和遠(yuǎn)期預(yù)后。結(jié)果住院期間,≥75歲女性組心原性死亡發(fā)生率明顯高于其他三組。Kaplan-Meier生存分析顯示≥75歲女性3年心原性死亡的發(fā)生率明顯高于其他三組患者(P0.05)。COX比例風(fēng)險(xiǎn)模型分析顯示:與75歲女性及75歲男性比,≥75歲女性是心原性死亡(HR=2.53,95%CI:1.15~5.59:HR=2.22,95%CI:1.26-3.91)和心原性死亡/心肌梗死(HR=2.26,95%CI:1.27~4.03:HR=2.25,95% CI:1.44-3.51)的獨(dú)立危險(xiǎn)因素。但與≥75歲男性相比,≥75歲女性不是心原性死亡(HR=1.30,95%CI:0.97~1.71)和心原性死亡/心肌梗死(HR=1.21,957 %CI:0.94-1.55)的獨(dú)立危險(xiǎn)因素。結(jié)論與其他人群相比,75歲及以上老年女性PCI術(shù)后住院期和遠(yuǎn)期預(yù)后較差,但其不是PCI術(shù)后預(yù)后不佳的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to analyze the clinical parameters and long-term follow-up results of acute myocardial infarction (acute myocardial infarction, AMI) complicated with acute pulmonary embolism (acute pulmonary embolism, APE), to discuss the risk factors of the disease, and to evaluate the efficacy and prognosis of antithrombotic drugs. Methods the clinical parameters of 34 patients with AMI combined with APE diagnosed in Fuwei Hospital from March 2004 to May 2014 were analyzed retrospectively. The patients were followed up by telephone and analyzed by Kaplan-Meier. Results the age 鈮,
本文編號:2266842
[Abstract]:Objective to analyze the clinical parameters and long-term follow-up results of acute myocardial infarction (acute myocardial infarction, AMI) complicated with acute pulmonary embolism (acute pulmonary embolism, APE), to discuss the risk factors of the disease, and to evaluate the efficacy and prognosis of antithrombotic drugs. Methods the clinical parameters of 34 patients with AMI combined with APE diagnosed in Fuwei Hospital from March 2004 to May 2014 were analyzed retrospectively. The patients were followed up by telephone and analyzed by Kaplan-Meier. Results the age 鈮,
本文編號:2266842
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