【摘要】：目的1.觀察陰虛陽亢型高血壓病伴失眠患者運用舒樂降壓顆粒聯(lián)合西藥治療的臨床療效。2.初步評價舒樂降壓顆粒的有效性及其安全性。方法選擇符合納入標(biāo)準(zhǔn)的福建中醫(yī)藥大學(xué)附屬人民醫(yī)院門診及住院患者60例并簽署知情同意書。將60例患者根據(jù)就診順序進行編號,然后由電腦產(chǎn)生隨機數(shù)字,按順序給每一例患者分配一個3位數(shù)的隨機數(shù)字,再將病例號根據(jù)對應(yīng)隨機數(shù)字的大小按從小到大的順序排列編號分為試驗組和對照組。①試驗組予舒樂降壓顆粒1袋bid(早、晚飯后開水沖服)+佐匹克隆(齊魯制藥H10980162每片3.75mg)3.75mgqd+氨氯地平(蘇州東瑞制藥H20020390每片5mg)5mgqd,14日血壓未達標(biāo)者加替米沙坦(勃林格殷格翰制藥H20090089每片80mg)80mg qd,治療4周。②對照組給藥方案:佐匹克隆(同上)3.75mgqd+氨氯地平(同上)5mgqd,14日血壓未達標(biāo)者加替米沙坦(同上)80mgqd,治療4周。兩組分別于試驗前,試驗后第2、4周觀察血壓、血常規(guī)、尿常規(guī)、血脂全套、肝功、腎功,常規(guī)心電圖、進行中醫(yī)辨證、SPIEGEL睡眠量表評分。搜集并整理治療前后的病例報告表及處理相關(guān)數(shù)據(jù)。結(jié)果1.治療后試驗組和對照組血壓較治療前均明顯降低,但試驗組與對照組有統(tǒng)計學(xué)差異(P0.05)。2.治療后試驗組和對照組睡眠較治療前均有改善,但試驗組與對照組有統(tǒng)計學(xué)差異(P0.05)。3.兩組治療后證候均有改善,但試驗組與對照組有統(tǒng)計學(xué)差異(P0.05)。4.兩組病人在治療中對照組出現(xiàn)1例不良反應(yīng),對該例停藥、隨訪并剔除處理,兩組在治療期間血常規(guī)、尿常規(guī)、血脂全套、肝功、腎功、常規(guī)心電圖未見明顯異常。結(jié)論1.通過治療前后對比,兩組均能降低血壓水平、改善睡眠及中醫(yī)證候,但試驗組明顯優(yōu)于對照組。說明舒樂降壓顆粒治療高血壓病伴失眠有一定的療效。舒樂降壓顆粒合常規(guī)西藥治療高血壓病伴失眠可試著用于臨床中。2.在整個課題實施過程中試驗組患者均未見明顯不適,且血常規(guī)、尿常規(guī)、血脂全套、肝功、腎功、常規(guī)心電圖未見明顯異常,表明舒樂降壓顆粒未見明顯副作用。
[Abstract]:Objective 1. To observe the clinical curative effect of Shule Jiangya granule combined with western medicine in patients with hyperactivity of yin and yang combined with insomnia. To evaluate the efficacy and safety of Shule Jiangya granules. Methods Sixty outpatients and inpatients in the people's Hospital affiliated to Fujian University of traditional Chinese Medicine were selected and signed informed consent. 60 patients were numbered according to the order of visit, and then random numbers were generated by computer, and each patient was assigned a random number of 3 digits in the order. According to the size of the corresponding random numbers, the case numbers were then divided into experimental group and control group according to the order from small to large. 1 bag of bid was given to the experimental group and control group. Zopicron (Qilu H10980162 / 3.75mg) 3.75mgqd amlodipine (Suzhou Dongrui H20020390 / 5mg) 5 mg QD, gatimisartan (Bollinger Ingerham H20090089 per 80mg) 80mg qd, treatment for 4 weeks Group A: zopicron (ibid.) 3.75mgqd amlodipine (ibid.) 5 mg QD, gatimisartan 80 mg QD for 4 weeks. Blood pressure, blood routine, urine routine, blood lipids, liver function, kidney function, routine electrocardiogram (ECG) and SPIEGEL sleep scale score were observed before and 2 weeks after the trial. Collect and arrange the case report form before and after treatment and deal with related data. Result 1. After treatment, the blood pressure of the experimental group and the control group were significantly lower than that of the control group, but there was a statistical difference between the experimental group and the control group (P0.05). After treatment, the sleep of the experimental group and the control group were improved, but there was a statistical difference between the experimental group and the control group (P0.05). After treatment, the syndromes of the two groups improved, but there was a statistical difference between the experimental group and the control group (P0.05). 4. One case of adverse reaction appeared in the control group in the treatment group. The patients were stopped the drug, followed up and eliminated. The blood routine, urine routine, blood lipid, liver function, renal function, routine electrocardiogram were not obviously abnormal in the two groups during the treatment period. Conclusion 1. By comparison before and after treatment, both groups can lower blood pressure, improve sleep and TCM syndrome, but the experimental group is better than the control group. It shows that Shule Jiangya granule has certain curative effect on hypertension with insomnia. Shule Jiangya granule combined with conventional western medicine in the treatment of hypertension with insomnia can be used in clinical. 2. 2. No obvious discomfort was found in the test group during the whole course of implementation, and blood routine, urine routine, blood lipids, liver function, renal function, routine electrocardiogram were not abnormal, which indicated that Shule Jiangya granule had no obvious side effects.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R544.1;R740

【相似文獻】

相關(guān)期刊論文 前10條

1 孟云輝;;高血壓病陰虛陽亢型客觀指標(biāo)研究進展[J];中西醫(yī)結(jié)合心腦血管病雜志;2009年05期

2 李平;;陰虛陽亢型高血壓病診治與調(diào)攝[J];中國現(xiàn)代藥物應(yīng)用;2009年20期

3 于占文;;自擬降壓湯治療陰虛陽亢型高血壓病98例觀察[J];浙江中醫(yī)雜志;2010年06期

4 黃習(xí)文;冼紹祥;;陰虛陽亢型高血壓胰島素抵抗與心肌纖維化相關(guān)性研究[J];中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志;2010年08期

5 丁延平;甲亢陰虛陽亢型患者心電圖P波及心房收縮時間間期分析[J];陜西中醫(yī)學(xué)院學(xué)報;2000年06期

6 紀(jì)莎,胡雯玲,曾茂貴;龍葵降壓湯治療陰虛陽亢型高血壓病57例[J];福建中醫(yī)學(xué)院學(xué)報;2003年03期

7 宋紅莉;;高血壓病陰虛陽亢型臨床研究進展[J];遼寧中醫(yī)藥大學(xué)學(xué)報;2009年05期

8 袁超;顧國龍;;中醫(yī)藥治療陰虛陽亢型高血壓病研究進展[J];中西醫(yī)結(jié)合心腦血管病雜志;2012年11期

9 丁青;郭振球;;潛熄寧治療陰虛陽亢型高血壓病60例臨床研究[J];中國中西醫(yī)結(jié)合雜志;1992年07期

10 郭維嘉;王耘;羅計;喬延江;;治療陰虛陽亢型高血壓方劑的藥性組合模式研究[J];世界科學(xué)技術(shù)(中醫(yī)藥現(xiàn)代化);2012年04期

相關(guān)會議論文 前3條

1 郭維佳;王耘;羅計;喬延江;;治療陰虛陽亢型高血壓方劑的藥性組合模式研究[A];中華中醫(yī)藥學(xué)會中藥分析分會第五屆學(xué)術(shù)交流會論文集[C];2012年

2 王志剛;李巧霞;;菊藤珍草湯治療高血壓病(陰虛陽亢型)療效觀察[A];甘肅省中醫(yī)藥學(xué)會2012年學(xué)術(shù)年會論文匯編[C];2012年

3 王君臣;;淺論腦血管意外(中風(fēng))恢復(fù)期的中醫(yī)治療[A];第三屆全國中西醫(yī)結(jié)合神經(jīng)系統(tǒng)疾病學(xué)術(shù)會議論文集[C];2000年

相關(guān)重要報紙文章 前2條

1 馬亮;陰虛陽亢型高血壓簡易療法[N];農(nóng)村醫(yī)藥報（漢）;2008年

2 江西省橫峰縣中醫(yī)院副主任醫(yī)師 李水銀;中醫(yī)辨治高血壓[N];保健時報;2006年

相關(guān)碩士學(xué)位論文 前10條

1 王宏如;天地降壓顆粒對陰虛陽亢型高血壓患者的生存質(zhì)量及神經(jīng)肽Y的影響[D];福建中醫(yī)藥大學(xué);2015年

2 熊艷萍;育陰潛陽安神方治療焦慮癥伴失眠（陰虛陽亢型）的臨床觀察[D];湖北中醫(yī)藥大學(xué);2015年

3 高文君;陰虛陽亢型高血壓病的中醫(yī)干預(yù)方案研究[D];四川醫(yī)科大學(xué);2015年

4 寇龍富;加味四物顆粒治療陰虛陽亢型高血壓病及其對CRP影響的研究[D];南京中醫(yī)藥大學(xué);2015年

5 李陽;明板降壓顆粒治療高血壓病（陰虛陽亢型）的臨床研究[D];長春中醫(yī)藥大學(xué);2015年

6 孫朝軍;加味建瓴湯治療無先兆偏頭痛（陰虛陽亢型）的臨床觀察[D];黑龍江中醫(yī)藥大學(xué);2016年

7 米孜古麗·艾尼娃;香天麻湯對陰虛陽亢型高血壓患者神經(jīng)遞質(zhì)影響的臨床觀察[D];新疆醫(yī)科大學(xué);2016年

8 馬正;加味清眩降壓湯治療老年單純收縮期高血壓（陰虛陽亢型）的臨床觀察[D];中國中醫(yī)科學(xué)院;2016年

9 徐曼;耳尖放血治療陰虛陽亢型高血壓病的即時療效觀察[D];南京中醫(yī)藥大學(xué);2017年

10 郭建業(yè);早泄方治療陰虛陽亢型早泄的臨床研究[D];廣州中醫(yī)藥大學(xué);2010年

，

本文編號：2226980