【摘要】：目的:綜合評(píng)價(jià)動(dòng)態(tài)動(dòng)脈硬化指數(shù)與冠心病的相關(guān)性,為冠心病的預(yù)防和診治提供循證醫(yī)學(xué)證據(jù)。方法:檢索相關(guān)期刊論文、萬(wàn)方數(shù)據(jù)庫(kù)、維普中文科技期刊全文數(shù)據(jù)庫(kù)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)、Pub Med、Embase、the Cochrane Library等數(shù)據(jù)庫(kù),收集有關(guān)“動(dòng)態(tài)動(dòng)脈硬化指數(shù)”與“冠狀動(dòng)脈性心臟病”的相關(guān)文獻(xiàn),提取相關(guān)數(shù)據(jù),采用Review Manager 5.3統(tǒng)計(jì)學(xué)軟件進(jìn)行Meta分析。結(jié)果:共納入17篇文獻(xiàn),包括4912例研究對(duì)象。Meta分析結(jié)果顯示:冠心病組動(dòng)態(tài)動(dòng)脈硬化指數(shù)高于正常對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義[MD=0.05,P0.00001]。失安全系數(shù)Nfs0.05為194,提示Meta分析結(jié)果穩(wěn)定可靠。進(jìn)一步根據(jù)病變支數(shù)分組行Meta分析,結(jié)果顯示:除單支病變組與正常對(duì)照組差異無(wú)統(tǒng)計(jì)學(xué)意義[MD=0.01,P0.05],其余各組間差異均存在統(tǒng)計(jì)學(xué)意義(MD分別為0.06、0.09、0.05、0.08、0.03,P值均小于0.05)。結(jié)論:動(dòng)態(tài)動(dòng)脈硬化指數(shù)與冠心病有相關(guān)性,且隨著冠狀動(dòng)脈病變程度的加重,動(dòng)態(tài)動(dòng)脈硬化指數(shù)與冠心病的相關(guān)性越強(qiáng)。
[Abstract]:Objective: to evaluate the correlation between dynamic arteriosclerosis index and coronary heart disease and to provide evidence for prevention and treatment of coronary heart disease. Methods: the databases of Chinese periodical full-text database, Wanfang database, Weipu Chinese sci-tech journal full-text database, Chinese biomedical literature database Pub Medbase and the Cochrane Library were searched. To collect the relevant literature about dynamic arteriosclerosis index and coronary heart disease, extract the relevant data, and use Review Manager 5.3 statistical software to carry out Meta analysis. Results: a total of 17 articles were included, including 4912 subjects. Meta-analysis results showed that the dynamic arteriosclerosis index of coronary heart disease group was higher than that of normal control group, and the difference was statistically significant [MDD 0.05 + P 0.00001]. The unsafe factor (Nfs0.05) is 194.This indicates that the results of Meta analysis are stable and reliable. Furthermore, Meta analysis was performed according to the number of lesion branches. The results showed that there was no significant difference between the single vessel lesion group and the normal control group (P < 0. 05), but there was significant difference between the other groups (MD was 0. 06 鹵0. 09%, 0. 05%, 0. 08% P < 0. 05). Conclusion: dynamic arteriosclerosis index is correlated with coronary artery disease, and the correlation between dynamic arteriosclerosis index and coronary heart disease is stronger with the severity of coronary artery disease.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R541.4

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本文編號(hào)：2157492