【摘要】：目的：評(píng)價(jià)同種藥物洗脫支架和不同種藥物洗脫支架治療冠狀動(dòng)脈藥物支架內(nèi)再狹窄的有效性。方法：計(jì)算機(jī)檢索檢索Pubmed數(shù)據(jù)庫(kù)、OVID數(shù)據(jù)庫(kù)、Embase數(shù)據(jù)庫(kù)、Cochrane圖書館、Google學(xué)術(shù)搜索、萬(wàn)方數(shù)據(jù)庫(kù)、中國(guó)學(xué)術(shù)期刊全文數(shù)據(jù)庫(kù)(CNKI)、中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(CBM)、維普數(shù)據(jù)庫(kù)(VIP),檢索文章時(shí)間為各大數(shù)據(jù)庫(kù)建庫(kù)至2014年10月。對(duì)符合納入標(biāo)準(zhǔn)的文獻(xiàn)用RevMan5.2軟件,系統(tǒng)評(píng)價(jià)不同種藥物洗脫支架治療藥物支架內(nèi)狹窄的靶病變血運(yùn)重建率或靶血管血運(yùn)重建率,次要療效指標(biāo)包括：主要不良心臟事件、病死率、心肌梗死發(fā)生率。收集同種和不同種藥物洗脫支架治療冠狀動(dòng)脈藥物支架內(nèi)再狹窄的相關(guān)研究,共納入10個(gè)臨床研究,1680名患者,使用RevMan 5.2軟件進(jìn)行系統(tǒng)評(píng)價(jià)。結(jié)果：在治療冠狀動(dòng)脈藥物支架內(nèi)再狹窄時(shí),不同藥物支架組的靶病變或靶血管血運(yùn)重建率低于同種藥物支架組,二者之間有統(tǒng)計(jì)學(xué)意義[OR=0.73,95%CI(0.55,0.96),P=0.02];不同藥物支架組的主要不良心臟事件發(fā)生率低于同種藥物支架組,兩組間存在統(tǒng)計(jì)學(xué)意義[OR=0.72,95%CI(0.54,0.96),P=0.03]。兩組間的病死率及心肌梗死發(fā)生率無(wú)顯著統(tǒng)計(jì)學(xué)差異[病死率的比較：OR=1.03,95%CI(0.49,2.16),P=0.95;心肌梗死發(fā)生率的比較：OR=0.59,95%CI(0.24,1.41),P=0.23]。結(jié)論：對(duì)于藥物洗脫支架內(nèi)再狹窄患者,再次植入不同藥物支架比植入相同支架更獲益。
[Abstract]:Aim: to evaluate the efficacy of drug-eluting stents and drug-eluting stents in the treatment of restenosis in coronary artery stents. Methods: Pubmed database and Embase database were searched by computer. Full text Database of Chinese academic Journals (CNKI), China Biomedical Literature Database (CBM), Wiper Database (VIP), retrieval time for each database was built up to October 2014. RevMan5.2 software was used to systematically evaluate the rate of revascularization or revascularization of target lesions in the treatment of stenosis in stents with different drug eluting stents. The secondary therapeutic effects included major adverse cardiac events. Mortality, incidence of myocardial infarction. A total of 1680 patients with coronary artery restenosis were enrolled in 10 clinical studies. The patients were systematically evaluated with RevMan 5.2 software in the treatment of intracoronary restenosis with the same or different drug eluting stents. Results: in the treatment of coronary stent restenosis, the target lesion or target vessel revascularization rate in different drug stent groups was lower than that in the same drug stent group. The incidence of major adverse cardiac events in different drug stent groups was lower than that in the same drug stent group, and there was statistical significance between the two groups [OR0.72 鹵95CI (0.540.96) P 0.03]. There was no significant difference in mortality and incidence of myocardial infarction between the two groups. Conclusion: for patients with drug-eluting stent restenosis, reimplantation of different stents is more beneficial than implantation of the same stent.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R541.4
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本文編號(hào)：2155227