伴糖耐量異常的原發(fā)性高血壓患者尿酸對血管損害的影響
發(fā)布時間：2018-07-20 11:30
【摘要】：目的：觀察伴糖耐量異常的原發(fā)性高血壓患者尿酸水平對頸動脈硬化及動脈僵硬度的影響。方法：選取2012年12月～2013年9月就診于我院的原發(fā)性高血壓患者513例,根據(jù)空腹血糖及餐后2h血糖分為糖耐量正常組267例、糖耐量異常組246例,通過一般資料的收集、血清學指標檢測及動脈僵硬度相關(guān)指標的測定,探究尿酸對伴糖耐量異常的原發(fā)性高血壓患者頸動脈硬化及動脈僵硬度的影響。結(jié)果：2組患者尿酸、空腹血糖、膽固醇、高密度脂蛋白、低密度脂蛋白、載脂蛋白B、堿性磷酸酶、糖化血紅蛋白比較,差異均有統(tǒng)計學意義(t值分別為-11.732、-9.657、-3.033、2.934、-3.183、-4.531、-2.271、-5.093,P均0.05),頸動脈內(nèi)膜中層厚度(IMT)、肱踝脈搏波傳導速度(baPWV)及斑塊發(fā)生率之間比較差異亦有統(tǒng)計學意義(t/χ2值分別為-3.999、-4.713、6.907,P均0.05),但左右兩側(cè)IMT、baPWV均無明顯統(tǒng)計學差異(t值分別為-3.604、-3.729,-4.496、-4.810,P均0.05),2組ABI差異無統(tǒng)計學意義(P0.05)。BaPWV的多元Logistic回歸分析示年齡、尿酸為動脈僵硬度的獨立危險因素(分別為OR=1.115,95%CI1.084～1.146, OR=1.004,95%CI 1.000～1.007,P均0.05)。結(jié)論：對于伴有糖耐量異常的原發(fā)性高血壓患者,應積極控制其血尿酸及血糖水平,以減少動脈硬化程度,進而減少血管的損害,防止心血管惡性事件的發(fā)生。
[Abstract]:Aim: to investigate the effect of uric acid level on carotid arteriosclerosis and arterial stiffness in patients with essential hypertension with impaired glucose tolerance. Methods: 513 patients with essential hypertension were selected from December 2012 to September 2013. According to fasting blood glucose and 2 h postprandial blood glucose, 267 patients with normal glucose tolerance and 246 patients with abnormal glucose tolerance were divided into two groups. To investigate the effect of uric acid on carotid arteriosclerosis and arterial stiffness in patients with essential hypertension with impaired glucose tolerance. Results comparison of uric acid, fasting blood glucose, cholesterol, high density lipoprotein, low density lipoprotein, apolipoprotein B, alkaline phosphatase, glycosylated hemoglobin, The differences were statistically significant (t = -11.732U -9.657U -3.033n 2.934U -3.183U -4.531U -2.271U -5.093g P 0.05), and there were also significant differences in carotid intima-media thickness (IMT), brachial ankle pulse velocity (baPWV) and plaque incidence (t / 蠂 ~ 2 = -3.999- 4.7136.907, respectively, P 0.05), but IMTBA PWV on both sides of the carotid artery was significantly different (t / 蠂 ~ 2 = -3.999- 4.7136.907, respectively), but IMTBA PWV on both sides of the carotid artery was significantly different (t / 蠂 ~ 2 = -3.9999-4.7136.907, respectively). There was no significant difference in ABI between the two groups (t = -3.604 (t = -3.729) -4.496 ~ (-4.810) P 0.05). There was no significant difference between the two groups in ABI (P0.05) .BaPWV multiple logistic regression analysis showed that there was no significant difference in ABI between the two groups. Uric acid was an independent risk factor for arterial stiffness (OR1. 115 / 95 CI 1.084 / 1.146, OR1. 004 / 95CI = 1. 000 / 1.007, P = 0. 05). Conclusion: for essential hypertension patients with abnormal glucose tolerance, the levels of serum uric acid and blood glucose should be controlled actively to reduce the degree of arteriosclerosis, thereby reduce the damage of blood vessels and prevent the occurrence of malignant cardiovascular events.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R544.11
，
本文編號：2133372
[Abstract]:Aim: to investigate the effect of uric acid level on carotid arteriosclerosis and arterial stiffness in patients with essential hypertension with impaired glucose tolerance. Methods: 513 patients with essential hypertension were selected from December 2012 to September 2013. According to fasting blood glucose and 2 h postprandial blood glucose, 267 patients with normal glucose tolerance and 246 patients with abnormal glucose tolerance were divided into two groups. To investigate the effect of uric acid on carotid arteriosclerosis and arterial stiffness in patients with essential hypertension with impaired glucose tolerance. Results comparison of uric acid, fasting blood glucose, cholesterol, high density lipoprotein, low density lipoprotein, apolipoprotein B, alkaline phosphatase, glycosylated hemoglobin, The differences were statistically significant (t = -11.732U -9.657U -3.033n 2.934U -3.183U -4.531U -2.271U -5.093g P 0.05), and there were also significant differences in carotid intima-media thickness (IMT), brachial ankle pulse velocity (baPWV) and plaque incidence (t / 蠂 ~ 2 = -3.999- 4.7136.907, respectively, P 0.05), but IMTBA PWV on both sides of the carotid artery was significantly different (t / 蠂 ~ 2 = -3.999- 4.7136.907, respectively), but IMTBA PWV on both sides of the carotid artery was significantly different (t / 蠂 ~ 2 = -3.9999-4.7136.907, respectively). There was no significant difference in ABI between the two groups (t = -3.604 (t = -3.729) -4.496 ~ (-4.810) P 0.05). There was no significant difference between the two groups in ABI (P0.05) .BaPWV multiple logistic regression analysis showed that there was no significant difference in ABI between the two groups. Uric acid was an independent risk factor for arterial stiffness (OR1. 115 / 95 CI 1.084 / 1.146, OR1. 004 / 95CI = 1. 000 / 1.007, P = 0. 05). Conclusion: for essential hypertension patients with abnormal glucose tolerance, the levels of serum uric acid and blood glucose should be controlled actively to reduce the degree of arteriosclerosis, thereby reduce the damage of blood vessels and prevent the occurrence of malignant cardiovascular events.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R544.11
，
本文編號：2133372
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