【摘要】：目的:探討血清ADAMTS-7在冠心病(CHD)患者中的表達(dá)水平,分析其與Gensini評(píng)分的相關(guān)性。方法:連續(xù)選取2016年4月至2017年2月在山西省人民醫(yī)院心內(nèi)科一病區(qū)住院的胸痛待查者389例,根據(jù)“納入和排除標(biāo)準(zhǔn)”,入組患者共151例,分為冠脈正常且無(wú)ST-T改變者31例,CHD組120例。所有入選病例統(tǒng)一檢測(cè)血脂、血糖、肝腎功、超敏C反應(yīng)蛋白等生化指標(biāo),ELISA法測(cè)定血清ADAMTS-7的水平。按冠脈造影(CAG)結(jié)果計(jì)算Gensini積分,以Gensini評(píng)分結(jié)果將CHD組分為Ⅰ組(4~8分)37例,Ⅱ組(9~12分)23例,Ⅲ組(13~33分)31例,Ⅳ組(34分及以上)29例;以及Gensini積分為0的非CHD組共5組。應(yīng)用兩獨(dú)立樣本t檢驗(yàn)評(píng)價(jià)CHD患者血清中ADAMTS-7水平,五組間ADAMTS-7水平比較應(yīng)用方差分析(ANOVA),分析ADAMTS-7與Gensini積分的相關(guān)性應(yīng)用Spearman偏相關(guān)。結(jié)果:1.CHD組的血清ADAMTS-7水平高于非CHD組,即[(71.44±27.33)ng/ml vs(36.17±14.02)ng/ml,P0.001]。2.CHD患者中Gensini積分Ⅳ組(34分及以上),Ⅲ組(13~33分),Ⅱ組(9~12分),Ⅰ組(4~8分)的血清ADAMTS-7水平均高于非CHD組的水平[(97.06±27.83)ng/ml,(75.38±25.40)ng/ml,(58.64±14.15)ng/ml,(56.01±17.76)ng/ml vs(36.17±14.02)ng/ml,P0.001]。CHD組內(nèi)比較時(shí),Ⅱ組的血清ADAMTS-7的水平略高于Ⅰ組,但無(wú)統(tǒng)計(jì)學(xué)差異(P0.05);剩余的Ⅳ組、Ⅲ組的血清ADAMTS-7水平均明顯高于Ⅱ組、Ⅰ組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);Ⅳ組與Ⅲ組之間的比較,差異也具有統(tǒng)計(jì)學(xué)意義(P0.05)。3.在調(diào)整了其他混雜因素后,ADAMTS-7水平與Gensini評(píng)分之間仍存在顯著相關(guān)性(r=0.479,P0.001)。結(jié)論:CHD患者血清ADAMTS-7水平明顯升高,隨著Gensini積分的增高,ADAMTS-7的水平逐漸增高,ADAMTS-7水平與Gensini評(píng)分呈正相關(guān),提示血清ADAMTS-7水平可作為評(píng)價(jià)冠脈病變程度的一個(gè)重要生化指標(biāo)。
[Abstract]:Aim: to investigate the expression of serum ADAMTS-7 in patients with coronary heart disease (CHD) and to analyze the correlation between ADAMTS-7 and Gensini score. Methods: a total of 389 patients with chest pain were selected from April 2016 to February 2017 in the Department of Cardiology, Shanxi Provincial people's Hospital. According to the criteria of inclusion and exclusion, 151 patients were enrolled. The patients were divided into 31 patients with normal coronary artery and no ST-T change, 120 patients with CHD. The serum levels of ADAMTS-7 were determined by Elisa in all the patients, including blood lipids, blood glucose, liver and kidney function, and hypersensitive C-reactive protein. According to the results of coronary angiography (CAG), the Gensini score was calculated. According to the Gensini score, CHD was divided into three groups: group 鈪，

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