【摘要】：目的:本研究以老年慢性心力衰竭患者為研究對(duì)象,監(jiān)測(cè)其CA125、尿酸、總膽紅素的水平,分析探討CA125、尿酸、總膽紅素對(duì)老年慢性心力衰是否具有診斷價(jià)值,及其與心功能分級(jí)的相關(guān)性,以期提供更多的客觀依據(jù)供臨床醫(yī)師參考,對(duì)老年慢性心力衰竭的診療提供新的指導(dǎo)意義。方法:1.收集2015年06月至2016年06月于陜西省人民醫(yī)院心內(nèi)三科住院的符合條件的慢性心力衰竭患者臨床資料,納入符合條件的慢性心力衰竭患者供98例,以同期健康體檢者52例作為對(duì)照組,按照Framingham心力衰竭診斷標(biāo)準(zhǔn)診斷的心衰組,將選取指標(biāo)進(jìn)行分析與對(duì)照組之間進(jìn)行單因素及多因素分析,進(jìn)一步分析有統(tǒng)計(jì)學(xué)意義的指標(biāo)是否有診斷價(jià)值;CA125與BNP之間進(jìn)行相關(guān)性分析。2.根據(jù)美國(guó)紐約心臟協(xié)會(huì)(NYHA)標(biāo)準(zhǔn)分級(jí),將心衰組分為三組(1組:心功能I/II級(jí)、2組:心功能III級(jí),3組.心功能IV級(jí)),分析所選取指標(biāo)與心功能分級(jí)等級(jí)的相關(guān)性。所有數(shù)據(jù)均采用SPSS19.0軟件進(jìn)行統(tǒng)計(jì)分析,以P0.05為差異具有統(tǒng)計(jì)學(xué)上的顯著性意義。結(jié)果:1.心衰組與對(duì)照組比較:BNP值對(duì)是否患病進(jìn)行診斷的準(zhǔn)確度高達(dá)83.5%,CA125對(duì)是否患病進(jìn)行診斷的準(zhǔn)確度高達(dá)73.8%。2.CA125與BNP的相關(guān)性分析:BNP和CA125之間存在著顯著的正向相關(guān)關(guān)系,二者之間的相關(guān)系數(shù)為0.5660。3.各項(xiàng)指標(biāo)與心功能分級(jí)的等級(jí)相關(guān)性分析:總膽紅素與心功能分級(jí)相關(guān)系數(shù)為0.836,尿酸與心功能分級(jí)相關(guān)系數(shù)為0.463,BNP與心功能分級(jí)相關(guān)系數(shù)為0.488,CA125心功能分級(jí)相關(guān)系數(shù)為0.679。結(jié)論:1.BNP及CA125對(duì)分別對(duì)慢性心力衰竭具有診斷價(jià)值。2.慢性心力衰竭患者外周血清CA125、血尿酸、總膽紅素含量隨NYHA心功能分級(jí)增高,對(duì)于慢性心力衰竭患者癥狀的嚴(yán)重程度具有良好評(píng)價(jià)功能。
[Abstract]:Objective: to investigate the diagnostic value of CA125, uric acid and total bilirubin in elderly patients with chronic heart failure. In order to provide more objective basis for clinicians, and to provide new guidance for the diagnosis and treatment of chronic heart failure in the elderly. Method 1: 1. From June 2015 to June 2016, clinical data of eligible patients with chronic heart failure (CHF) were collected and 98 eligible CHF patients were included. In the same period, 52 healthy persons were used as the control group. The selected indexes were analyzed by single factor analysis and multivariate analysis between the two groups according to the diagnosis criteria of Fraingham heart failure. Further analysis of the statistical significance of whether there is diagnostic value of CA125 and BNP correlation analysis. 2. 2. According to the New York Heart Association (NYHA) standard classification, the heart failure group was divided into three groups (group 1: cardiac function I / II class 2: cardiac function class III). To analyze the correlation between the indexes selected and the grade of cardiac function. All the data were analyzed by SPSS 19.0 software, with P0.05 as the statistical significance. The result is 1: 1. Compared with the control group, the diagnostic accuracy of the ratio of BNP to the disease was as high as 83.5% and the accuracy of CA125 was as high as 73.8.2.The correlation between CA125 and BNP was significant positive correlation between BNP and CA125. The correlation coefficient between them is 0.5660.3. The correlation coefficient between total bilirubin and cardiac function grade was 0.836, and the correlation coefficient between uric acid and cardiac function grade was 0.463nb BNP and cardiac function grade was 0.488GCA 125, the correlation coefficient was 0.6799.The correlation coefficient between total bilirubin and cardiac function grade was 0.836, and the correlation coefficient between uric acid and cardiac function grade was 0.463g BNP. Conclusion 1. BNP and CA 125 have diagnostic value in chronic heart failure. The levels of serum CA 125, uric acid and total bilirubin in peripheral blood of patients with chronic heart failure were increased with NYHA cardiac function grade, which had a good function in evaluating the severity of symptoms in patients with chronic heart failure.
【學(xué)位授予單位】：延安大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R541.6

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