【摘要】：心臟淋巴管的生理病理作用一直未引起人們的重視。但近年來,隨著血管內(nèi)皮生長因子受體-3(vascular endothelial growth factor receptor 3,VEGFR-3)、淋巴管內(nèi)皮細(xì)胞透明質(zhì)酸受體(lymphatic vessel endothelial hyaluronan receptor 1,LYVE-1)、果蠅同源基因轉(zhuǎn)錄因子(prospero homeobox protein 1,Prox-1)、腎小球足細(xì)胞膜黏蛋白(podoplanin)等淋巴管內(nèi)皮細(xì)胞標(biāo)志物的發(fā)現(xiàn),心臟淋巴管的研究迅速發(fā)展。心臟淋巴管引流淋巴液,其功能異�？梢鹦募∷[、動(dòng)脈硬化、心律失常、間質(zhì)纖維化等。深入認(rèn)識(shí)心臟淋巴管的生理病理作用,對于治療心肌梗死、改善心血管功能、預(yù)防心臟手術(shù)后并發(fā)癥等有著重要意義。本文綜述了心臟淋巴管的發(fā)生、分布以及與心血管疾病預(yù)后的關(guān)系。
[Abstract]:The physiological and pathological effects of the cardiac lymphatics have not been paid attention to, but in recent years, with the vascular endothelial growth factor receptor -3 (vascular endothelial growth factor receptor 3, VEGFR-3), the hyaluronic acid receptor of the lymphatic endothelial cells (lymphatic vessel endothelial hyaluronan receptor 1), the transcription of the homologous gene of the Drosophila melanogaster Factors (Prospero homeobox protein 1, Prox-1), the discovery of lymphovascular endothelial cell markers such as glomerular podocyte membrane mucin (Podoplanin), and the rapid development of the lymphatic vessels of the heart. Lymphatic drainage of the lymph, the abnormal function of the heart can cause myocardial edema, arteriosclerosis, arrhythmia, interstitial fibrosis and so on. Deep understanding of the heart drench The physiological and pathological effects of the bile duct are important for the treatment of myocardial infarction, the improvement of cardiovascular function and the prevention of complications after cardiac surgery. This article reviews the occurrence and distribution of the cardiac lymphatics and its relationship with the prognosis of cardiovascular diseases.
【作者單位】： 復(fù)旦大學(xué)上海醫(yī)學(xué)院人體解剖與組織胚胎學(xué)系;
【基金】：國家自然科學(xué)基金(81270200,81470385) 高等學(xué)校博士學(xué)科點(diǎn)專項(xiàng)科研基金(20130071110080)~~
【分類號(hào)】：R54
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本文編號(hào)：2120387