本文選題：25-羥基維生素D + 冠狀動脈狹窄　； 參考：《青海大學》2017年碩士論文

【摘要】：目的維生素D在人體發(fā)揮著十分重要的作用,而且有多重生物學效應(yīng)。近年來發(fā)現(xiàn)低水平的維生素D可增加心血管疾病、高血壓及肥胖的發(fā)病風險,而冠心病是全世界最常見的疾病,故本研究的目的在于探討25-(OH)D水平是否與冠心病患者冠狀動脈狹窄相關(guān)。方法納入2015年1月-2016年09月在青海省人民醫(yī)院心內(nèi)科住院的可疑冠心病患者共183例,其中男性103例,女性80例,平均年齡66.76±6.53歲,男女不限,該183例患者在行冠狀動脈造影前均測定血清25-(OH)D水平。根據(jù)冠脈造影結(jié)果分為冠狀動脈狹窄組和冠狀動脈正常組,其中冠狀動脈狹窄組共107例,男性58例,女性49例,平均年齡66.47±6.38歲,冠狀動脈正常組共76例,男性45例,女性31例,平均年齡67.17±6.76歲,然后進行統(tǒng)計學分析。結(jié)果兩組患者的性別、年齡、總膽固醇、甘油三酯、高密度脂蛋白、收縮壓及舒張壓等比較,差異沒有統(tǒng)計學意義(P0.05),兩組在LDL、25-(OH)D水平方面比較差異有統(tǒng)計學意義(P0.05);血清25-(OH)D水平與冠狀動脈狹窄(Gensini評分)之間呈明顯負相關(guān),低密度脂蛋白水平與與冠狀動脈狹窄(Gensini評分)之間無相關(guān)性。結(jié)論血清25-(OH)D水平與冠狀動脈狹窄呈明顯負相關(guān),除目前已確定的冠心病的危險因素之外,血清25-(OH)D可作為冠心病的另一個重要危險因素。
[Abstract]:Objective Vitamin D plays an important role in human body and has many biological effects. Low levels of vitamin D have been found in recent years to increase the risk of cardiovascular disease, hypertension and obesity, and coronary heart disease is the most common disease in the world. The aim of this study was to investigate whether 25-(OH) D level is associated with coronary artery stenosis in patients with coronary heart disease. Methods from January 2015 to September 2016, 183 patients with suspected coronary heart disease were enrolled in Department of Cardiology, Qinghai Provincial people's Hospital, including 103 males and 80 females, with an average age of 66.76 鹵6.53 years. Serum 25-(OH) D levels were measured before coronary angiography in 183 patients. According to the results of coronary angiography, there were 107 patients in coronary artery stenosis group and normal coronary artery group. There were 58 males and 49 females with an average age of 66.47 鹵6.38 years. There were 76 cases in normal coronary artery group, 45 males and 31 females. The average age was 67.17 鹵6.76 years, and then statistical analysis was made. Results Sex, age, total cholesterol, triglyceride, high density lipoprotein, systolic blood pressure and diastolic blood pressure were compared between the two groups. There was no significant difference between the two groups (P0.05), there was significant difference in LDL25- (OH) D level between the two groups (P0.05), there was a significant negative correlation between serum 25- (OH) D level and coronary artery stenosis (Gensini score). There was no correlation between LDL level and coronary artery stenosis (Gensini score). Conclusion Serum 25- (OH) D level is negatively correlated with coronary artery stenosis. In addition to the established risk factors of coronary heart disease, serum 25- (OH) D may be another important risk factor for coronary heart disease.
【學位授予單位】：青海大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R541.4

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1 林蓉香;青海地區(qū)冠心病患者血清25-羥基維生素D水平與冠狀動脈狹窄的相關(guān)性研究[D];青海大學;2017年

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