本文選題：冠心病 + ABO血型��； 參考：《寧夏醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:研究ABO血型與冠心病的相關(guān)關(guān)系。方法:收集2013年3月至2016年3月在我院行冠狀動脈造影(CAG)病例資料,設(shè)置病例組和對照組,病例組為任意1支≥50%,余歸為對照組。記錄CAG患者的ABO血型,統(tǒng)計并分析ABO血型與其CAG結(jié)果相關(guān)關(guān)系。并將冠心病組分為單支、雙支、多支病變組,通過每組中ABO血型的構(gòu)成比分析冠狀動脈病變支數(shù)與血型分布的關(guān)系。利用Gensini積分明確ABO血型分布與冠狀動脈狹窄的關(guān)系。研究冠心病與ABO血型及其各危險因素之間的相關(guān)關(guān)系采用logistic回歸分析模型,P0.05為差異有統(tǒng)計學(xué)意義。結(jié)果:1.565例已明確血型的患者中,統(tǒng)計發(fā)現(xiàn)兩組中年齡、性別、吸煙率、肥胖指數(shù)、吸煙率的P均0.05,差異均無統(tǒng)計學(xué)意義。而糖尿病患病率、高脂血癥患者比例,P均0.05,差異有統(tǒng)計學(xué)意義。2.對冠心病組和對照組ABO血型分布的進(jìn)行統(tǒng)計分析,兩組中ABO血型分布差異有統(tǒng)計學(xué)意義(P0.05)。兩組間A型血與非A型血的分布差異有統(tǒng)計學(xué)意義(P0.01)、O型血與非O型血的分布差異有統(tǒng)計學(xué)意義(P0.05)。兩組間B型血與非B型血,AB型血與非AB型血分布差異均無統(tǒng)計學(xué)意義。logistic多元回歸模型分析ABO血型分布與CHD的關(guān)系提示A血型者較O血型者患冠心病的風(fēng)險高且差異有統(tǒng)計學(xué)意義(P0.05)。在冠心病各亞組間比較發(fā)現(xiàn),冠狀動脈病變支數(shù)越多,A型血患者的比例越高。在每一亞組內(nèi)A型血所占比例均最高,O型血比例最低。研究發(fā)現(xiàn)A型組的Gensini積分最高。結(jié)論:1.ABO血型可能與冠心病發(fā)病存在一定的相關(guān)性,且A型可能較其它血型患冠心病的風(fēng)險高;2.A型血冠狀動脈病變程度較其它血型重。
[Abstract]:Objective: to study the relationship between ABO blood group and coronary heart disease. Methods: coronary angiography (CAG) was performed in our hospital from March 2013 to March 2016. Case group and control group were set up. ABO blood groups of CAG patients were recorded, and the correlation between ABO blood groups and CAG results was analyzed. The coronary artery disease was divided into single, double and multi-vessel groups. The relationship between the number of coronary artery disease branches and the distribution of blood group was analyzed by the ratio of ABO blood group in each group. The relationship between ABO blood group distribution and coronary artery stenosis was determined by Gensini integral. To study the correlation between coronary heart disease (CHD) and ABO blood type and its risk factors, the logistic regression model was used to analyze the correlation between them. Results the age, sex, smoking rate, obesity index, smoking rate of the two groups were all 0.05, and there was no significant difference between the two groups in terms of age, sex, smoking rate and smoking rate (P < 0.05). The prevalence of diabetes mellitus and the proportion of hyperlipidemia patients were 0.05, the difference was statistically significant. The distribution of ABO blood group in coronary heart disease group and control group was statistically analyzed. The difference of ABO blood group distribution between the two groups was statistically significant (P0.05). There was significant difference between the two groups in the distribution of type A blood and non-type A blood (P0.01). There was significant difference between O type blood and non-O type blood distribution (P0.05). There was no significant difference between the distribution of type B blood and non-type B blood between the two groups. Logistic regression model analysis of the relationship between ABO blood group distribution and CHD suggests that the risk of coronary heart disease is higher and worse in A blood group than in O blood group. The difference was statistically significant (P0.05). Compared with each subgroup of coronary heart disease, the more branches of coronary artery disease, the higher the proportion of patients with type A blood. In each subgroup, the proportion of type A blood was the highest and the proportion of type O blood was the lowest. It was found that type A group had the highest Gensini integral. Conclusion 1. ABO blood group may be associated with coronary heart disease, and type A may have a higher risk of coronary heart disease than other blood groups. 2. The severity of coronary artery disease of type A is heavier than that of other blood groups.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R541.4

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