本文選題：自發(fā)性高血壓大鼠 + 腦基底動脈��； 參考：《安徽醫(yī)科大學學報》2017年06期

【摘要】：目的探討硫化氫(H_2S)對不同周齡自發(fā)性高血壓大鼠(SHR)離體腦基底動脈舒張反應的影響。方法選取14、40周齡SHR和正常Wistar京都(WKY)大鼠各6只,測量血壓后,急性分離腦基底動脈,應用壓力肌動圖技術檢測不同濃度硫氫化鈉(NaHS)對大鼠腦基底動脈直徑變化的影響。結果 (1)10、30、100、300、1 000、3 000 mmol/L的NaHS能夠濃度依賴地舒張SHR和WKY大鼠腦基底動脈;(2)與14周齡的WKY相比,1 000、3 000 mmol/L的Na HS對14周齡SHR的舒張率更明顯,兩者間有顯著性差異(P0.05);(3)與40周齡的WKY大鼠相比,1 000、3 000 mol/L的NaHS對40周齡SHR的舒張率降低,兩者間有顯著性差異(P0.05)。結論在高血壓初期,腦基底動脈對H_2S的敏感性增加,而隨著高血壓的發(fā)展及血管功能的嚴重損傷,腦基底動脈可能對H_2S的敏感性降低。
[Abstract]:Objective to investigate the effect of hydrogen sulfide (H _ 2S) on diastolic response of isolated cerebral basilar artery in spontaneously hypertensive rats (SHR) of different weeks. Methods six SHR and six normal Wistar Kyoto (WKY) rats aged 14 and 40 weeks were selected. After blood pressure was measured, the cerebral basilar artery was separated. The effect of sodium sulfide (NaHS) at different concentrations on the diameter of cerebral basilar artery in rats was detected by pressure actin technique. Results (1) the basilar arteries of SHR and WKY rats could be dilated in a concentration-dependent manner by NaHS at 10, 30, 100, 000, 000, 000, 000 mmol / L, (2) the relaxation rate of 1 000 ~ 3 000 mmol / L NaHS on SHR at 14 weeks was more obvious than that of WKY at 14 weeks old, and the relaxation rate of NAHS was significantly higher than that of WKY at 14 weeks of age. There was a significant difference between the two groups (P0.05); (3) and 40 weeks old WKY rats compared with the 40 week old WKY rats, the relaxation rate of 10 000 mol / L NaHS was significantly lower than that of 40 week old WKY rats (P0.05). Conclusion in the early stage of hypertension, the sensitivity of cerebral basilar artery to H2S is increased, but with the development of hypertension and the serious injury of vascular function, the sensitivity of cerebral basilar artery to H2S may decrease.
【作者單位】： 石河子大學醫(yī)學院生理學教研室;石河子大學醫(yī)學院病理生理學教研室;
【基金】：國家自然科學基金(編號:31460264、81460098、81560081、81600325、81660271)
【分類號】：R544.1

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