本文選題：亞臨床甲減 + 冠心病�。� 參考：《新疆醫(yī)科大學》2017年碩士論文

【摘要】：目的:了解亞臨床甲減(SCH)對血脂和血小板平均體積(MPV)的影響,探討其與冠脈病變嚴重程度的關系。方法:本文回顧性分析在2015年06月至2015年12月在我院心內科住院并經冠脈造影初次確診為冠心病的患者,據其甲功分為重度亞臨床甲減組(22例),輕度亞臨床甲減組(71例)和甲功正常組(217例),并記錄實驗室檢查及冠脈造影結果,據病變血管支數、冠脈病變的Gensini積分相應分組。記錄人口學特征和既往史,測定他們次日空腹的血生化指標并分析組間差異;比較亞臨床甲減和TSH在不同冠脈病變程度分組中患病率和平均水平,觀察亞臨床甲減與冠脈病變的關系。結果:重度亞臨床甲減組(TSH≥10uIU/ml)血脂(TC、LDL、LPa、ApoB)、MPV、Gensini積分較輕度亞臨床甲減組(TSH:4.5-9.9mIU/L)和甲功正常組(TSH4.5mIU/L)高,TG水平高于甲功正常組(P0.05)。輕度亞臨床甲減組TC和MPV水平高于甲功正常組(P0.05)。亞臨床甲減在多支病變組中的患病率較單支病變組高(P0.05)。亞臨床甲減患者根據Gensini積分分組后C組(Gensini≥40)在TSH、BUN水平與A組(Gensin積分20)和B組(Gensini積分20-39)比較有統(tǒng)計學意義,在血脂(TC、LDL、LPa)、MPV水平與A組比較有統(tǒng)計學意義。結論:重度亞臨床甲減組和輕度亞臨床甲減組與甲功正常組相比,血脂水平、血小板平均體積之間存在著差異,重度亞臨床甲減對血脂紊亂的影響更大。亞臨床甲減多見于多支病變組,多支病變組平均TSH水平較單支病變組高,隨著TSH水平越高,Gensini積分越高,冠脈病變范圍及狹窄程度越重。
[Abstract]:Objective: to investigate the effects of subclinical hypothyroidism (SCH) on blood lipids and mean platelet volume (MPV) in patients with coronary artery disease. Methods: the patients who were hospitalized in our hospital from June 2015 to December 2015 and were diagnosed with coronary artery disease by coronary angiography were analyzed retrospectively. The patients were divided into severe subclinical hypothyroidism group (n = 22) and mild subclinical hypothyroidism group (n = 71) and normal thyroid function group (n = 217). The results of laboratory examination and coronary angiography were recorded. The demographic characteristics and past history were recorded, the fasting blood biochemical indexes were measured and the differences between the two groups were analyzed, and the prevalence and average levels of subclinical hypothyroidism and TSH in different coronary lesion groups were compared. To observe the relationship between subclinical hypothyroidism and coronary artery disease. Results: in severe subclinical hypothyroidism group (TSH 鈮，

本文編號：2019845