本文選題：瘦素 + 可溶性瘦素受體�。� 參考：《廣東醫(yī)學》2017年10期

【摘要】：目的探討瘦素抵抗(LR)與高血壓左室肥厚(LVH)及動脈粥樣硬化(AS)之間的關(guān)系。方法選擇原發(fā)性高血壓(EH)患者80例及健康體檢者40例,應(yīng)用酶聯(lián)免疫吸附法(ELISA)測受試者血清瘦素(LP)、可溶性瘦素受體(SLR)水平,行超聲檢查測定左室質(zhì)量指數(shù)(LVMI)及頸動脈內(nèi)膜-中層厚度(c IMT),依據(jù)LVMI及c IMT分別分為高血壓左心室肥厚組40例(HLVH組)、EH不伴LVH組40例(non-LVH組)、健康體檢者40例(對照組)及c IMT增厚組61例、c IMT正常組59例。結(jié)果 (1)non-LVH組血清LP水平高于對照組,血清SLR水平低于對照組(P0.05),HLVH組血清LP水平高于non-LVH組及對照組,血清SLR水平低于non-LVH組及對照組(P0.05)。(2)c IMT增厚組血清LP水平高于c IMT正常組,血清SLR水平低于c IMT正常組。(3)LP與LVMI及c IMT呈顯著正相關(guān)(r=0.757,0.694,P0.001),SLR與LVMI及c IMT呈顯著負相關(guān)(r=-0.682,-0.708,P0.001)。結(jié)論血清LP及SLR水平與LVMI及c IMT密切相關(guān),說明LP抵抗可能參與了高血壓LVH及AS的形成和發(fā)展。
[Abstract]:Objective to investigate the relationship between leptin resistance (LRR) and left ventricular hypertrophy (LVH) and atherosclerosis (ASA) in patients with hypertension. Methods 80 patients with essential hypertension (EH) and 40 healthy controls were selected. The serum leptin LPU and soluble leptin receptor (SLR) levels were measured by enzyme linked immunosorbent assay (Elisa). The left ventricular mass index (LVMI) and carotid intima-media thickness (IMT) were measured by echocardiography. According to LVMI and c IMT, 40 cases of EH without LVH and 40 cases of non-LVH were divided into two groups according to LVMI and c IMT. ) and c IMT thickening group (n = 61) and c IMT normal group (n = 59). Results the serum LP level in non-LVH group was higher than that in control group, the serum SLR level in HLVH group was lower than that in non-LVH group and control group, and the serum SLR level in non-LVH group and control group was lower than that in non-LVH group and control group. The level of serum SLR was significantly lower than that of the normal group of c IMT. There was a significant positive correlation between SLR and LVMI and c IMT. There was a significant negative correlation between SLR and LVMI and c IMT (P 0. 001) and a significant negative correlation between SLR and LVMI and c IMT (P 0. 001). Conclusion Serum LP and SLR levels are closely related to LVMI and c IMT, suggesting that LP resistance may be involved in the formation and development of LVH and as in hypertension.
【作者單位】： 桂林醫(yī)學院附屬醫(yī)院中西結(jié)合病區(qū);
【基金】：廣西科學研究與技術(shù)開發(fā)計劃項目(編號:桂科能1598025-29)
【分類號】：R544.1

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本文編號：1991946