本文選題：左卡尼汀注射液 + 阿托伐他汀鈣片　； 參考：《中國臨床藥理學(xué)雜志》2017年05期

【摘要】：目的觀察左卡尼汀注射液聯(lián)合阿托伐他汀鈣片治療慢性心力衰竭的臨床療效及安全性。方法將72例慢性心力衰竭患者隨機(jī)分為對(duì)照組36例與試驗(yàn)組36例。對(duì)照組予以阿托伐他汀鈣10 mg,qd,口服;試驗(yàn)組在對(duì)照組治療的基礎(chǔ)上,予以20 mg·kg~(-1)左卡尼汀注射液,qd,靜脈推注。2組患者一個(gè)周期均為21 d,共治療2個(gè)周期。比較2組患者的臨床療效、核轉(zhuǎn)錄因子-κB、白細(xì)胞介素~(-1)β、C反應(yīng)蛋白、血漿腦利鈉肽、左心室內(nèi)徑、左心室射血分?jǐn)?shù)、6 min步行試驗(yàn)最大距離,以及藥物不良反應(yīng)的發(fā)生情況。結(jié)果治療后,試驗(yàn)組和對(duì)照組的總有效率分別為83.33%(30/36例)和61.11%(22/36例),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組和對(duì)照組的核轉(zhuǎn)錄因子-κB分別為(34.44±3.50),(49.57±5.17)pg·L~(-1);白細(xì)胞介素~(-1)β分別為(0.42±0.05),(0.59±0.07)μg·L~(-1);C反應(yīng)蛋白分別為(10.04±1.11),(13.29±1.44)ng·L~(-1);血漿腦利鈉肽分別為(241.63±25.77),(340.92±35.16)pg·L~(-1);左心室內(nèi)徑分別為(49.19±5.12),(52.11±5.44)mm;左心室射血分?jǐn)?shù)分別為(49.39±5.12)%,(41.02±4.15)%;6 min步行試驗(yàn)最大距離分別為(376.09±40.15),(262.98±28.71)m,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。試驗(yàn)組的藥物不良反應(yīng)主要有胃腸道不適和口干,對(duì)照組的藥物不良反應(yīng)主要有胃腸道不適、視覺模糊和皮疹。試驗(yàn)組和對(duì)照組的藥物不良反應(yīng)發(fā)生率分別為5.56%和11.11%,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論左卡尼汀注射液聯(lián)合阿托伐他汀鈣片治療慢性心力衰竭的臨床療效顯著,且不增加藥物不良反應(yīng)的發(fā)生率。
[Abstract]:Objective to observe the clinical efficacy and safety of levacarnitine injection combined with Atto vastatin calcium tablets in the treatment of chronic heart failure. Methods 72 patients with chronic heart failure were randomly divided into control group (n = 36) and trial group (n = 36). The control group was given Atto vastatin calcium 10 mg / g QD, and the experimental group was treated with 20 mg / kg of L-carnitine injection on the basis of treatment in the control group. The patients in group 2 received intravenous injection for 21 days and were treated for 2 cycles. The clinical efficacy, nuclear transcription factor-魏 B, interleukin-1) 尾 -C reactive protein, plasma brain natriuretic peptide, left ventricular diameter, maximum distance of left ventricular ejection fraction (LVEF) 6 min walking test and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 83.33 / 30 / 36 and 61.11 / 22 / 36, respectively. The difference was statistically significant (P 0.05). After treatment, 璇曢獙緇勫拰瀵圭収緇勭殑鏍歌漿褰曞洜瀛，

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