本文選題：下肢缺血性疾病 + 重組質(zhì)粒肝細(xì)胞生長(zhǎng)因子��； 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的通過(guò)多中心、隨機(jī)、雙盲、多劑量(包括安慰劑)平行對(duì)照的臨床試驗(yàn)探索重組質(zhì)粒肝細(xì)胞生長(zhǎng)因子注射液治療下肢缺血性疾病的有效性與安全性。方法選擇初篩合格的患者作為下肢缺血性疾病的研究的病例模型(本次均選擇慢性下肢動(dòng)脈缺血性疾病伴潰瘍形成病例,有利于臨床觀察),對(duì)患肢沿脛前、脛后動(dòng)脈走形選擇32點(diǎn)注射(共注射三次D0、D14、D28),并對(duì)每個(gè)注射病例進(jìn)行臨床隨訪觀察6個(gè)月,了解缺血性潰瘍愈合情況、踝肱指數(shù)(ABI)及經(jīng)皮氧分壓(Tc PO2)變化情況。結(jié)果注射重組質(zhì)粒肝細(xì)胞生長(zhǎng)因子隨機(jī)、雙盲臨床實(shí)驗(yàn)所選臨床8例受試者中7例下肢血供明顯改善,潰瘍愈合或潰瘍面積明顯縮小。潰瘍面積總體呈逐漸減小進(jìn)而愈合趨勢(shì)。結(jié)論重組質(zhì)粒肝細(xì)胞生長(zhǎng)因子通過(guò)促進(jìn)下肢動(dòng)脈毛細(xì)血管再生,從而改善缺血區(qū)域血供并促進(jìn)潰瘍的愈合。重組質(zhì)粒-肝細(xì)胞生長(zhǎng)因子治療下肢缺血性疾病是一種安全且有效的方法。
[Abstract]:Objective to investigate the efficacy and safety of recombinant plasmid hepatocyte growth factor injection in the treatment of ischemic disease of lower extremity by multicenter, randomized, double-blind, multi-dose (including placebo) parallel controlled clinical trials. Methods the eligible patients were selected as the case model for the study of ischemic disease of lower extremity (all of them were selected as cases of chronic arterial ischemic disease of lower extremity with ulceration, which was beneficial to clinical observation and to the anterior tibia of the affected limb. The posterior tibial artery was injected at 32 points (three times D0 D14 D28), and each case was followed up for 6 months to find out the healing of ischemic ulcer, ankle brachial index (ABI) and percutaneous partial pressure of oxygen (TcPO2). Results the blood supply of lower extremity was improved significantly in 7 of 8 subjects who were randomly injected with recombinant plasmid hepatocyte growth factor, and the ulcer healing or ulcer area was reduced obviously. The ulcer area decreased gradually and then healed. Conclusion the recombinant plasmid hepatocyte growth factor can improve the blood supply of ischemic region and promote the healing of ulcer by promoting the regeneration of lower extremity artery capillary. The recombinant plasmids-hepatocyte growth factor (HGF) is a safe and effective method for the treatment of ischemic diseases of lower extremities.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R543

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