本文選題：高血壓 + 冠狀動脈疾病��； 參考：《中國循環(huán)雜志》2017年05期

【摘要】：目的:探討高血壓患者24 h動態(tài)脈壓(24hPP)、24 h動態(tài)脈壓指數(shù)(24hPPI)和夜間動態(tài)脈壓指數(shù)(NPPI)與冠心病的相關(guān)性。方法:共入選305例于2016-05至2016-07在阜外醫(yī)院進行動態(tài)血壓監(jiān)測(ABPM)的受試者,根據(jù)ABPM數(shù)據(jù)計算受試者的24hPP、24hPPI和NPPI,并分析這些指標與冠心病的相關(guān)性。24hPP為24 h平均收縮壓(24hSBP)與24 h平均舒張壓(24hDBP)之差,24hPPI為24hPP與24hSBP的比值,NPPI為夜間(22:00~06:00)平均PP與平均SBP的比值。結(jié)果:305例受試者中,222例(72.8%)為高血壓患者。高血壓患者的24hPP、24hPPI、NPPI均高于血壓正常者[24hPP:(49.0±11.6)mmHg(1 mmHg=0.133 kPa)vs.(42.2±7.4)mmHg,P0.001;24hPPI:0.39±0.06 vs.0.37±0.05,P=0.004;NPPI:0.40±0.07 vs.0.38±0.05,P=0.009]。222例高血壓患者中,116例(52.3%)冠心病患者的24hPP、24hPPI和NPPI均高于106例(47.7%)無冠心病者[24hPP:(50.9±12.2)mmHg vs.(47.0±10.6)mmHg,P=0.013;24hPPI:0.41±0.06 vs.0.38±0.06,P0.001;NPPI:0.42±0.07 vs.0.38±0.06,P0.001];而在83例(27.2%)血壓正常的受試者中,冠心病患者和無冠心病者上述指標之間的差異均無統(tǒng)計學意義。Logistic回歸模型分析顯示,調(diào)整年齡、性別、體重指數(shù)、降壓藥服用情況等因素后,高血壓患者的24hPPI和NPPI與冠心病相關(guān)[24hPPI:比值比(OR)=1.95,95%可信區(qū)間(CI):1.11~3.44,P=0.020;NPPI:OR=2.21,95%CI:1.28~3.82,P0.001]。受試者工作特征(ROC)曲線分析結(jié)果顯示,高血壓患者的24hPPI和NPPI對冠心病的篩查和預測價值均優(yōu)于24hPP。結(jié)論:高血壓患者的24hPPI和NPPI與冠心病密切相關(guān),有助于高血壓患者冠心病的篩查和預測,且效果優(yōu)于24hPP。
[Abstract]:Objective: to investigate the correlation between 24 h dynamic pulse pressure (24 h) and 24 h NPPI (dynamic pulse pressure index (NPPI) and coronary heart disease (CHD) in patients with hypertension. Methods: a total of 305 subjects were selected to perform ambulatory blood pressure monitoring (ABPM) in Fuwei Hospital from May 2005 to July 2016-07. The correlation between these indexes and coronary heart disease was analyzed according to the ABPM data. The difference between 24hPP (24 h SBP) and 24 h mean diastolic blood pressure (24hDBP) was the ratio of 24hPP to 24hSBP. The ratio of NPPI to 24hSBP was 22: 0006: 00 at night. Results among 305 subjects, 222 cases were diagnosed as hypertensive patients. 楂樿鍘嬫?zhèn)ｈ�呯殑24hPP,24hPPI,NPPI鍧囬珮浜庤鍘嬫甯歌，

本文編號：1976328