本文選題：替羅非班 + 抗血小板�。� 參考：《中國(guó)醫(yī)院藥學(xué)雜志》2017年04期

【摘要】：目的:探討替羅非班圍手術(shù)期應(yīng)用對(duì)行藥物洗脫支架(DES)置入老年冠心病患者出血、血小板減少及主要不良心血管事件(MACE)發(fā)生風(fēng)險(xiǎn)的影響。方法:研究對(duì)象選取某院2011年1月-2015年6月收治行DES置入老年冠心病患者共200例,采用隨機(jī)數(shù)字表法分為對(duì)照組(100例)和觀察組(100例),分別在術(shù)后給予常規(guī)二聯(lián)抗血小板方案單用和在此基礎(chǔ)上加用替羅非班治療,比較2組患者TIMI出血分級(jí)情況、血小板減少率及隨訪MACE發(fā)生率等。結(jié)果:2組患者TIMI出血分級(jí)情況比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);2組患者血小板減少率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);同時(shí)觀察組患者隨訪MACE發(fā)生率顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:替羅非班圍手術(shù)期應(yīng)用用于行DES置入老年冠心病患者可有效降低遠(yuǎn)期MACE發(fā)生風(fēng)險(xiǎn),改善臨床預(yù)后,且未導(dǎo)致術(shù)后出血和血小板減少情況加重。
[Abstract]:Objective: to investigate the effect of perioperative use of tirofiban on the risk of bleeding, thrombocytopenia and major adverse cardiovascular events in elderly patients with coronary heart disease (CHD) by drug-eluting stents (des). Methods: a total of 200 elderly patients with coronary heart disease were treated with DES from January 2011 to June 2015. The patients in the observation group were divided into control group (n = 100) and observation group (n = 100). The patients in the two groups were treated with routine anti-platelet regimen and tirofiban respectively. The bleeding grade of TIMI was compared between the two groups. The rate of thrombocytopenia and the incidence of MACE were followed up. Results there was no significant difference in TIMI bleeding grade between the two groups. There was no significant difference in the thrombocytopenia rate between the two groups. The incidence of MACE in the observation group was significantly lower than that in the control group (P 0.05). Conclusion: the perioperative application of tirofiban for DES implantation in elderly patients with coronary heart disease can effectively reduce the risk of long-term MACE and improve the clinical prognosis without exacerbating postoperative bleeding and thrombocytopenia.
【作者單位】： 滄州市中心醫(yī)院心內(nèi)二科;
【分類號(hào)】：R541.4

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