發(fā)布時間：2018-05-29 15:33

  本文選題：急性心肌梗死 + 生長分化因子-　； 參考：《廣東醫(yī)學》2017年23期

【摘要】：目的探討血清生長分化因子-15(GDF-15)水平與急性心肌梗死(AMI)冠狀動脈SYNTAX評分的相關性。方法采用雙抗體夾心酶聯(lián)免疫吸附法(ELISA)測定63例AMI患者與65例非冠心病(NCHD)患者血清GDF-15水平,并采集臨床資料,測定生化指標。根據(jù)冠狀動脈造影檢查結(jié)果采用SYNTAX評分軟件計算AMI患者SYNTAX評分。分析GDF-15水平與SYNTAX評分的相關性。結(jié)果 AMI組血清GDF-15水平明顯高于NCHD組[(1 252.06±488.38)ng/L vs(699.75+185.44)ng/L],差異有統(tǒng)計學意義(P0.05)。校正可能影響冠脈SYNTAX評分的因素后,GDF-15水平顯著影響SYNTAX評分(F=7.684,P0.01),二者具有正相關性(r=0.444,P0.01)。結(jié)論 GDF-15水平與AMI冠脈SYNTAX評分具有相關性,可能為AMI新的標記物,預測AMI冠脈嚴重程度及預后。
[Abstract]:Objective to investigate the correlation between serum growth differentiation factor-15 (GDF-15) and coronary artery SYNTAX score (SYNTAX) in patients with acute myocardial infarction (AMI). Methods the serum GDF-15 levels in 63 patients with AMI and 65 patients with non-coronary heart disease were measured by double antibody sandwich enzyme-linked immunosorbent assay (Elisa). Clinical data were collected and biochemical indexes were measured. According to the results of coronary angiography, the SYNTAX score of AMI patients was calculated by SYNTAX score software. The correlation between GDF-15 level and SYNTAX score was analyzed. Results the serum GDF-15 level in AMI group was significantly higher than that in NCHD group [1 252.06 鹵488.38)ng/L vs(699.75 185.44)ng/L] (P 0.05). Correction of the factors that may affect coronary SYNTAX scores after GDF-15 significantly affected the SYNTAX score (P 0.01). There was a positive correlation between GDF-15 and FG 7. 684, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, respectively. Conclusion the level of GDF-15 is correlated with the SYNTAX score of AMI coronary artery, which may be a new marker of AMI and predict the severity and prognosis of AMI coronary artery.
【作者單位】： 承德市中心醫(yī)院心內(nèi)科;
【基金】：河北省醫(yī)學科學研究重點課題計劃項目(編號:ZD20140455) 承德市科學技術研究與發(fā)展計劃項目(編號:201422002)
【分類號】：R542.22

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相關期刊論文 前10條

1 梁瀛;牛杰;高煒;;生長分化因子-15的心血管作用[J];心血管病學進展;2009年06期

2 魯鋒;;生長分化因子-15在心血管疾病中的研究進展[J];醫(yī)學信息(中旬刊);2010年12期

3 張s，

本文編號：1951396