本文選題：急性心肌梗死 + 生長(zhǎng)分化因子-　； 參考：《廣東醫(yī)學(xué)》2017年23期

【摘要】：目的探討血清生長(zhǎng)分化因子-15(GDF-15)水平與急性心肌梗死(AMI)冠狀動(dòng)脈SYNTAX評(píng)分的相關(guān)性。方法采用雙抗體夾心酶聯(lián)免疫吸附法(ELISA)測(cè)定63例AMI患者與65例非冠心病(NCHD)患者血清GDF-15水平,并采集臨床資料,測(cè)定生化指標(biāo)。根據(jù)冠狀動(dòng)脈造影檢查結(jié)果采用SYNTAX評(píng)分軟件計(jì)算AMI患者SYNTAX評(píng)分。分析GDF-15水平與SYNTAX評(píng)分的相關(guān)性。結(jié)果 AMI組血清GDF-15水平明顯高于NCHD組[(1 252.06±488.38)ng/L vs(699.75+185.44)ng/L],差異有統(tǒng)計(jì)學(xué)意義(P0.05)。校正可能影響冠脈SYNTAX評(píng)分的因素后,GDF-15水平顯著影響SYNTAX評(píng)分(F=7.684,P0.01),二者具有正相關(guān)性(r=0.444,P0.01)。結(jié)論 GDF-15水平與AMI冠脈SYNTAX評(píng)分具有相關(guān)性,可能為AMI新的標(biāo)記物,預(yù)測(cè)AMI冠脈嚴(yán)重程度及預(yù)后。
[Abstract]:Objective to investigate the correlation between serum growth differentiation factor-15 (GDF-15) and coronary artery SYNTAX score (SYNTAX) in patients with acute myocardial infarction (AMI). Methods the serum GDF-15 levels in 63 patients with AMI and 65 patients with non-coronary heart disease were measured by double antibody sandwich enzyme-linked immunosorbent assay (Elisa). Clinical data were collected and biochemical indexes were measured. According to the results of coronary angiography, the SYNTAX score of AMI patients was calculated by SYNTAX score software. The correlation between GDF-15 level and SYNTAX score was analyzed. Results the serum GDF-15 level in AMI group was significantly higher than that in NCHD group [1 252.06 鹵488.38)ng/L vs(699.75 185.44)ng/L] (P 0.05). Correction of the factors that may affect coronary SYNTAX scores after GDF-15 significantly affected the SYNTAX score (P 0.01). There was a positive correlation between GDF-15 and FG 7. 684, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, P 0. 01, respectively. Conclusion the level of GDF-15 is correlated with the SYNTAX score of AMI coronary artery, which may be a new marker of AMI and predict the severity and prognosis of AMI coronary artery.
【作者單位】： 承德市中心醫(yī)院心內(nèi)科;
【基金】：河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題計(jì)劃項(xiàng)目(編號(hào):ZD20140455) 承德市科學(xué)技術(shù)研究與發(fā)展計(jì)劃項(xiàng)目(編號(hào):201422002)
【分類號(hào)】：R542.22

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本文編號(hào)：1951396