本文選題：急性下肢深靜脈血栓形成 + 雙通道�。� 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:探討雙通道連續(xù)給藥治療急性下肢深靜脈血栓形成的臨床療效方法:回顧性分析我院收治的急性下肢深靜脈血栓(DVT)128例患者的臨床資料,根據(jù)給藥途徑分為雙通道組(乆靜脈鞘管+溶栓導(dǎo)管)60例,單通道組(溶栓導(dǎo)管)68例。分析兩組溶栓治療前后健患側(cè)大腿周徑差、小腿周徑差、大腿消腫率、小腿消腫率、靜脈通暢率、尿激酶總量、溶栓天數(shù)及并發(fā)癥(出血率、肺栓塞發(fā)生率、導(dǎo)管相關(guān)性感染)。結(jié)果:溶栓治療前兩組的性別、年齡、患肢、血栓類型、髂靜脈受壓例數(shù),以及健患側(cè)大腿周徑差、小腿周徑差均未見(jiàn)明顯差異(P0.05)。溶栓治療后,雙通道組的健患側(cè)大腿周徑差(1.22±0.62)明顯小于單通道組(1.70±0.94),大腿消腫率(0.86±0.06)明顯優(yōu)于單通道組(P0.05),雙通道組尿激酶用量(3.85×106U)、溶栓天數(shù)(6.5天)較單通道組尿激酶用量(4.85×106U)、溶栓天數(shù)(9天)明顯減少(P0.05)。治療前后健患側(cè)小腿周徑差及消腫率無(wú)差別(P0.05),治療后兩組患者靜脈通暢率及并發(fā)癥的發(fā)生率無(wú)明顯差異(P0.05)。結(jié)論:兩種途徑治療急性下肢深靜脈血栓形成臨床效果確切,雙通道組較單通道組溶栓藥物用量少、溶栓時(shí)間短、臨床癥狀改善明顯,值得在臨床上應(yīng)用。
[Abstract]:Objective: to investigate the clinical efficacy of double channel continuous administration in the treatment of acute deep venous thrombosis of lower extremity. Methods: the clinical data of 128 patients with DVT of acute deep venous thrombosis of lower extremity treated in our hospital were analyzed retrospectively. According to the way of administration, the patients were divided into two channels group (60 patients with thrombolytic catheter in the vein sheath tube and 68 patients with thrombolytic catheter with single channel group). The difference of thigh diameter, leg diameter, thigh swelling rate, lower leg swelling rate, venous patency rate, urokinase amount, thrombolytic days and complications (bleeding rate, pulmonary embolism rate, catheter-related infection) were analyzed before and after thrombolytic therapy. Results: before thrombolytic therapy, there were no significant differences in sex, age, limb, thrombus type, number of cases of iliac vein compression, thigh diameter difference and leg circumference difference between the two groups. After thrombolysis, The thigh circumference difference of the two channel group (1.22 鹵0.62) was significantly lower than that of the single channel group (1.70 鹵0.94), and the thigh swelling rate was 0.86 鹵0.06), which was significantly better than that of the single channel group (P 0.05). The dosage of urokinase in the double channel group was 3.85 脳 10 6 UU, the days of thrombolysis was 6.5 days) and the number of days of thrombolytic thrombolysis was 4.85 脳 10 6 U (P < 0.05). P0. 05% decreased significantly (P 0. 05%, P 0. 05%). Before and after treatment, there was no difference in the difference of the diameter of the leg and the rate of detumescence between the two groups (P 0.05), but there was no significant difference in the rate of venous patency and the incidence of complications between the two groups after treatment. Conclusion: the two approaches are effective in the treatment of acute deep vein thrombosis of lower extremity. The dosage of thrombolytic drugs in the double channel group is less than that in the single channel group, the duration of thrombolysis is shorter, and the clinical symptoms are obviously improved, which is worthy of clinical application.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R543.6

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