本文選題：原發(fā)性高血壓 + 晨峰血壓�。� 參考：《鄭州大學(xué)》2017年碩士論文

【摘要】：目的本研究通過對原發(fā)性高血壓患者進行24小時動態(tài)血壓監(jiān)測及生化檢驗,探討晨峰血壓與血尿酸的關(guān)系,為原發(fā)性高血壓患者的晨峰血壓管理提供依據(jù)。方法入選2014年11月至2015年12月住院的原發(fā)性高血壓患者(n=195),另入選同期健康體檢者為正常對照組(n=88)。對高血壓病患者行24h動態(tài)血壓(24h ABPM)監(jiān)測,根據(jù)監(jiān)測結(jié)果將高血壓病患者分為晨峰組(n=93)、非晨峰組(n=102);所有研究對象禁食12h后于動態(tài)血壓監(jiān)測當(dāng)天早晨行尿酸、血糖、膽固醇、甘油三酯、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、尿素、肌酐檢測,并記錄一般臨床資料。結(jié)果1.晨峰組、非晨峰組膽固醇水平均高于正常對照組,差異有統(tǒng)計學(xué)意義(P0.05)。2.24h ABPM顯示:晨峰組全天、白天平均收縮壓均保持較高水平,顯著高于非晨峰組,差異有統(tǒng)計學(xué)意義(P0.05)。3.三組平均尿酸水平存在差異,晨峰組高于非晨峰組,兩組均高于正常對照組,差異有統(tǒng)計學(xué)意義(P0.05)。4.相關(guān)分析提示晨峰血壓與尿酸(r=0.384,P0.01)呈正相關(guān);多元線性回歸分析顯示尿酸水平與血壓晨峰呈獨立正相關(guān)(B=0.05,P0.01)。結(jié)論1.血尿酸水平與高血壓密切相關(guān),是高血壓的影響因素。2.高血壓病患者中血尿酸與晨峰血壓呈正相關(guān),是晨峰血壓的一個獨立危險因素。
[Abstract]:Objective to investigate the relationship between morning peak blood pressure and serum uric acid in patients with essential hypertension by 24 hours ambulatory blood pressure monitoring and biochemical test, and to provide evidence for the management of morning peak blood pressure in patients with essential hypertension. Methods essential hypertension patients admitted from November 2014 to December 2015 were enrolled in the study. The patients were divided into morning peak group (n = 93) and non-morning peak group (n = 102). All the subjects were fasting for 12 hours and were given uric acid, blood glucose and cholesterol in the morning after fasting for 12 hours, according to the monitoring results, the patients with hypertension were divided into three groups: morning peak group (n = 93), non-morning peak group (n = 10) and control group (n = 12). Triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol, urea, creatinine were detected and general clinical data were recorded. Result 1. The cholesterol levels in morning peak group and non morning peak group were higher than those in normal control group, and the difference was statistically significant (P 0.05) .2.24 h ABPM showed that the mean systolic blood pressure of morning peak group remained high throughout the day, and significantly higher than that of non-morning peak group, the difference being statistically significant (P 0.05). The average uric acid level of the three groups was higher than that of the non-morning peak group, and the two groups were higher than the normal control group, the difference was statistically significant. Correlation analysis showed that there was a positive correlation between morning peak blood pressure and uric acid 0.384 (P 0.01), and multiple linear regression analysis showed that uric acid level was positively correlated with blood pressure (P 0.01). Conclusion 1. The level of serum uric acid is closely related to hypertension, which is the influencing factor of hypertension. Serum uric acid was positively correlated with morning peak blood pressure in patients with hypertension and was an independent risk factor of morning peak blood pressure.
【學(xué)位授予單位】：鄭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R544.11

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相關(guān)期刊論文 前10條

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