本文選題：心臟生理活動(dòng) + 非勻質(zhì)性��； 參考：《生物化學(xué)與生物物理進(jìn)展》2017年09期

【摘要】：為了更深入地了解目前靠生理實(shí)驗(yàn)及臨床手段無法洞察的心臟三維空間的電生理運(yùn)行機(jī)制,分析和表現(xiàn)心臟復(fù)雜的電生理活動(dòng),從而揭示心臟的生理物理特性,本研究通過人類心肌細(xì)胞的動(dòng)作電位傳導(dǎo)數(shù)學(xué)模型,結(jié)合基于心臟解剖數(shù)據(jù)所建立的真實(shí)心臟組織結(jié)構(gòu)的三維空間模型,構(gòu)建出精細(xì)的心臟生物物理融合模型,并將心臟在三維空間中的生物物理活動(dòng)表現(xiàn)出來.實(shí)驗(yàn)結(jié)果表明,基于心臟動(dòng)作電位傳導(dǎo)的融合模型,不同時(shí)刻的動(dòng)作電位傳導(dǎo)在非勻質(zhì)性組織內(nèi)的三維空間中的傳播位置、空間關(guān)系以及生物物理過程被清晰地顯示出來,心臟研究人員從而能夠以視覺感知的方式認(rèn)識和深入理解人類心臟電生物物理系統(tǒng)的功能機(jī)制,并有助于進(jìn)一步推測心臟的生理和病理反應(yīng).
[Abstract]:In order to understand the electrophysiological mechanism of the heart in three dimensional space, which can not be understood by physiological experiments and clinical methods, and to analyze and express the complex electrophysiological activities of the heart, so as to reveal the physiological and physical characteristics of the heart. Based on the mathematical model of action potential conduction of human cardiomyocytes and the three-dimensional model of the real heart tissue structure based on the anatomical data of the heart, a fine heart biophysical fusion model was constructed in this study. The biophysical activity of the heart in three-dimensional space is also shown. The experimental results show that, based on the fusion model of cardiac action potential conduction, the transmission position, spatial relationship and biophysical process of action potential conduction at different times in the three-dimensional space of heterogeneous tissue are clearly displayed. Heart researchers are thus able to understand and understand the functional mechanisms of human cardiac electrobiophysical systems in a visual perceptual manner, and to further speculate on the physiological and pathological responses of the heart.
【作者單位】： 山東大學(xué)計(jì)算機(jī)科學(xué)與技術(shù)學(xué)院;山東大學(xué)機(jī)電與信息工程學(xué)院;中國海洋大學(xué)教育技術(shù)系;哈爾濱學(xué)院藝術(shù)與設(shè)計(jì)學(xué)院;哈爾濱工業(yè)大學(xué)計(jì)算機(jī)科學(xué)與技術(shù)學(xué)院;中國科學(xué)院聲學(xué)研究所;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(61502275,61501450)~~
【分類號】：R54
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本文編號：1868836