本文選題：螺旋波 + 后除極化�。� 參考：《物理學(xué)報(bào)》2017年06期

【摘要】：突然的心臟死亡常常由心臟的心律失常引起,而心律失常常與后除極化有關(guān).本文采用人類心臟模型研究了二維心肌組織中存在螺旋波或其他波斑圖下后除極化的發(fā)生,通過改變L型鈣電導(dǎo)和快鉀電導(dǎo)讓螺旋波演化,觀察后除極化在空間的分布.研究發(fā)現(xiàn):在單細(xì)胞和一維情況下不出現(xiàn)后除極化時(shí),螺旋波可導(dǎo)致相II型和相III型早期后除極化、延遲后除極化、增強(qiáng)的自動(dòng)性,以及延時(shí)激發(fā)和延時(shí)增強(qiáng)自動(dòng)性的出現(xiàn);還觀察到螺旋波導(dǎo)致膜電位在動(dòng)作電位I期出現(xiàn)弱振蕩;后除極化一般出現(xiàn)在螺旋波波核區(qū)域,它是由螺旋波的相奇異點(diǎn)引起.后除極化也可以分布在更大的范圍,當(dāng)參數(shù)選取適當(dāng)時(shí),出現(xiàn)早期后除極化、延遲后除極化、增強(qiáng)自動(dòng)性的空間點(diǎn)在空間呈螺旋線分布,展示記憶效應(yīng).通過觀察各種離子電流變化發(fā)現(xiàn):當(dāng)激發(fā)細(xì)胞的鈉電流很小時(shí)可誘發(fā)L型鈣電流、鈉鈣交換電流的增大和慢鉀電流、快鉀電流的減少,導(dǎo)致各種后除極化的產(chǎn)生,因此增大鈉電流可有效抑制后除極化的發(fā)生.
[Abstract]:Sudden cardiac death is often caused by cardiac arrhythmia, which is often associated with depolarization. In this paper, a human heart model was used to study the occurrence of depolarization in two-dimensional myocardial tissue under helical wave or other wave patterns. The spatial distribution of posterior depolarization was observed by changing L-type calcium conductance and fast potassium conductance to the evolution of spiral wave. It is found that in the case of single cell and one-dimensional depolarization, helical wave can lead to early depolarization of phase II and phase III, delayed depolarization, automatic enhancement, and the appearance of delay excitation and delay enhancement. It is also observed that the membrane potential oscillates weakly in phase I of the action potential, and the depolarization occurs in the region of the helical wave nucleus, which is caused by the phase singularity of the helical wave. The depolarization can also be distributed in a larger range. When the parameters are selected properly, the early depolarization, the delayed depolarization, and the spatial point of enhanced automatism are spiral distribution in space, showing the memory effect. By observing the changes of various ion currents, it was found that the L-type calcium current, the increase of sodium calcium exchange current, the decrease of slow potassium current and the decrease of fast potassium current could induce L type calcium current when the sodium current of the stimulated cells was very small, which resulted in the generation of various kinds of depolarization. Therefore, increasing sodium current can effectively inhibit the occurrence of depolarization.
【作者單位】： 廣西師范大學(xué)物理科學(xué)與技術(shù)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金(批準(zhǔn)號(hào):11565005,11365003)資助的課題~~
【分類號(hào)】：R540.4

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