本文選題：左旋氨氯地平 + 替米沙坦��； 參考：《中國(guó)藥房》2017年15期

【摘要】：目的:觀察左旋氨氯地平、替米沙坦聯(lián)合氫氯噻嗪治療反杓型高血壓的療效和安全性。方法:150例反杓型高血壓患者隨機(jī)分為A、B、C組,每組50例。A組患者給予替米沙坦片40 mg+氫氯噻嗪片10 mg,每日1次,清晨口服;B組患者給予左旋氨氯地平片5 mg,每日1次,晚間口服;C組患者給予替米沙坦片(用法用量同A組)+氫氯噻嗪片(用法用量同A組)+左旋氨氯地平片(用法用量同B組)。3組療程均為8周。觀察并比較3組患者治療前后電解質(zhì)水平、24 h動(dòng)態(tài)血壓變化情況及治療后反杓型節(jié)律逆轉(zhuǎn)為正常杓型節(jié)律的逆轉(zhuǎn)率,記錄不良反應(yīng)發(fā)生情況。結(jié)果:3組患者治療前后電解質(zhì)水平比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,3組患者24 h血壓比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);治療后,3組患者24 h血壓均顯著低于同組治療前,且C組均顯著低于A組和B組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,C組反杓型節(jié)律逆轉(zhuǎn)率顯著高于A組和B組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。3組患者不良反應(yīng)發(fā)生率比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:左旋氨氯地平、替米沙坦聯(lián)合氫氯噻嗪分時(shí)服藥治療反杓型高血壓不僅可以降低患者24 h血壓,還能有效逆轉(zhuǎn)反杓型節(jié)律,安全性亦較好。
[Abstract]:Aim: to observe the efficacy and safety of levamlodipine, telmisartan and hydrochlorothiazide in the treatment of antidipper hypertension. Methods one hundred and fifty patients with antidipper hypertension were randomly divided into group A (n = 50) and group A (n = 50) were given telmisartan 40 mg hydrochlorothiazide 10 mg once a day, and group B was given levamlodipine 5 mg once a day in the morning. Evening oral administration of telmisartan tablet (same dosage as group A) hydrochlorothiazide tablet (same dosage as group A) levamlodipine tablet (administration dosage same as group B) was used for 8 weeks. The changes of ambulatory blood pressure (ABBP) at 24 h before and after treatment and the reversal rate of anti-dipper rhythm to normal dipper rhythm were observed and compared before and after treatment, and the adverse reactions were recorded. Results there was no significant difference in electrolyte levels between the three groups before and after treatment (P 0.05). There was no significant difference in 24 h blood pressure between group C and group B before treatment, but the blood pressure of group C was significantly lower than that of group A and group B at 24 h after treatment, and the difference was statistically significant (P 0.05). After treatment, the reverse rate of anti-dipper rhythm in group C was significantly higher than that in group A and group B, and the difference was statistically significant. Conclusion: levamlodipine and telmisartan combined with hydrochlorothiazide in the treatment of antidipper hypertension can not only reduce the blood pressure of 24 hours, but also reverse the antidipper rhythm effectively.
【作者單位】： 衡水市哈勵(lì)遜國(guó)際和平醫(yī)院老年病一科;
【基金】：衡水市科技計(jì)劃自籌經(jīng)費(fèi)項(xiàng)目(No.2016014091Z)
【分類號(hào)】：R544.1

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