本文選題：冠心病 + 經(jīng)皮冠狀動脈介入治療��； 參考：《中國藥房》2017年24期

【摘要】：目的:探討通心絡(luò)膠囊對冠心病患者經(jīng)皮冠狀動脈介入治療(PCI)術(shù)后血清親環(huán)素A(CyPA)和基質(zhì)金屬蛋白酶9(MMP-9)的影響。方法:擬行PCI術(shù)的115例冠心病患者隨機分為對照組(59例)和觀察組(56例)。對照組患者給予常規(guī)治療;觀察組患者在對照組治療的基礎(chǔ)上于術(shù)后第1天開始口服通心絡(luò)膠囊0.78 g,每日3次,連用6個月。觀察兩組患者手術(shù)前后的CyPA、MMP-9水平及不良反應(yīng)發(fā)生情況。結(jié)果:術(shù)前,兩組患者血清CyPA、MMP-9水平比較,差異均無統(tǒng)計學(xué)意義(P0.05)。兩組患者術(shù)后1 d、1個月及對照組患者術(shù)后6個月CyPA水平均顯著高于同組術(shù)前,但觀察組術(shù)后1、6個月顯著低于對照組,且隨時間延長逐漸降低,差異均有統(tǒng)計學(xué)意義(P0.05);術(shù)后1 d兩組間及觀察組術(shù)后6個月CyPA水平與術(shù)前比較,差異均無統(tǒng)計學(xué)意義(P0.05)。兩組患者術(shù)后1 d、1個月MMP-9水平均顯著高于同組術(shù)前,但觀察組顯著低于對照組,且隨時間延長逐漸降低,差異均有統(tǒng)計學(xué)意義(P0.05);兩組患者術(shù)后6個月MMP-9水平與術(shù)前比較,差異均無統(tǒng)計學(xué)意義(P0.05)。兩組患者不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:在常規(guī)治療的基礎(chǔ)上,通心絡(luò)膠囊可顯著降低冠心病患者PCI術(shù)后的CyPA、MMP-9水平,且未增加不良反應(yīng)的發(fā)生。
[Abstract]:Objective: to investigate the effect of Tongxinluo capsule (TXL) on serum cyclophile Acycline (Acyclin) and matrix metalloproteinase 9 (MMP-9) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: one hundred and fifteen patients with coronary heart disease were randomly divided into control group (n = 59) and observation group (n = 56). The patients in the control group were given routine treatment, and the patients in the observation group were given Tongxinluo capsule 0.78 g on the first day after operation, 3 times a day for 6 months. The level of MMP-9 and the incidence of adverse reactions were observed before and after operation. Results: there was no significant difference between the two groups in the serum levels of CyPA-MMP-9 before operation (P 0.05). The level of CyPA in the two groups was significantly higher than that in the control group at 1 day, 1 month and 6 months after operation, but the level of CyPA in the observation group was significantly lower than that in the control group at 1 and 6 months after operation, and decreased gradually with the prolongation of time. There was no significant difference in CyPA level between the two groups and 6 months after operation, and there was no significant difference between the two groups on the 1st day after operation and 6 months after operation (P 0.05). The level of MMP-9 in the two groups was significantly higher than that in the same group at 1 day and 1 month after operation, but the level of MMP-9 in the observation group was significantly lower than that in the control group, and gradually decreased with the prolongation of time, the difference being statistically significant (P 0.05), the level of MMP-9 in the two groups at 6 months after operation was compared with that before operation. The difference was not statistically significant (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: Tongxinluo capsule can significantly reduce the level of CyPA-MMP-9 in patients with coronary heart disease after PCI, and does not increase the incidence of adverse reactions on the basis of routine treatment.
【作者單位】： 宣城市人民醫(yī)院;
【分類號】：R541.4

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