發(fā)布時(shí)間：2018-05-01 03:34

  本文選題：H型高血壓 + 頸動(dòng)脈內(nèi)中膜厚度��； 參考：《青海大學(xué)》2016年碩士論文

【摘要】：目的:探討血清同型半胱氨酸、胱抑素-c、尿酸水平與H型高血壓患者頸動(dòng)脈內(nèi)中膜厚度的相關(guān)性,為動(dòng)脈粥樣硬化疾病的早期干預(yù)及治療提供理論依據(jù)。方法:根據(jù)入選、排除標(biāo)準(zhǔn),選取2014年12月-2015年10月青海大學(xué)附屬醫(yī)院入院治療的H型高血壓3級(jí)患者101例,男53例、女48例。詳細(xì)記錄患者病史,測(cè)量血壓,身高、體重,計(jì)算體重指數(shù),測(cè)定血漿同型半胱氨酸、胱抑素-c、尿酸,空腹血糖、甘油三酯、總膽固醇、高密度脂蛋白、低密度脂蛋白(LDL-C)、載脂蛋白A、載脂蛋白B等指標(biāo),并行頸動(dòng)脈彩超檢查,根據(jù)頸動(dòng)脈內(nèi)中膜厚度分三組:頸動(dòng)脈內(nèi)中膜正常組34例、頸動(dòng)脈硬化組31例、頸動(dòng)脈斑塊組36例,并將正常組設(shè)置為對(duì)照組。檢測(cè)并比較3組的血清指標(biāo),分析其與頸動(dòng)脈內(nèi)中膜厚度的關(guān)系。利用SPSS20.0進(jìn)行統(tǒng)計(jì)分析。結(jié)果:1、三組間性別、年齡、吸煙史、飲酒史、病史、FBG、TG、TC、LDL-C、APOA、APOB、BMI等指標(biāo)比較差異均無統(tǒng)計(jì)學(xué)意義(P0.05)。2、三組間Hcy、Cyst-c、UA、HDL-C的比較分別為:Hcy水平比較:斑塊組對(duì)照組,硬化組對(duì)照組(P0.05);Cyst-c水平比較均為:斑塊組對(duì)照組(P0.05);UA水平比較:斑塊組對(duì)照組(P0.05);HDL-C水平比較:斑塊組對(duì)照組,硬化組對(duì)照組(P0.05)。3、Hcy、Cyst-C、UA與cIMT的相關(guān)性分析:Hcy、Cyst-C、UA與c IMT呈正相關(guān)(0.334、0.317、0.442,P值分別為0.001、0.001、0.000);HDL-C與cIMT呈負(fù)相關(guān)(r=-0.293,P=0.003)。結(jié)論:血清Hcy、Cyst-c、UA是AS的危險(xiǎn)因素,HDL-C是AS的保護(hù)性因子,監(jiān)測(cè)血清中各項(xiàng)指標(biāo)水平的變化,對(duì)AS疾病的早期干預(yù)及治療具有一定的參考價(jià)值。
[Abstract]:Objective: to investigate the correlation between serum homocysteine, cystatin-cand uric acid levels and carotid intima-media thickness in patients with H type hypertension, and to provide theoretical basis for early intervention and treatment of atherosclerosis. Methods: according to the inclusion and exclusion criteria, 101 H type hypertension grade 3 patients, 53 males and 48 females, were admitted to the affiliated Hospital of Qinghai University from December 2014 to October 2015. Record the patient's history, measure blood pressure, height, weight, calculate body mass index, measure plasma homocysteine, cystatin, uric acid, fasting blood glucose, triglyceride, total cholesterol, high density lipoprotein, measure plasma homocysteine, cystatin, uric acid, fasting blood glucose, triglyceride, total cholesterol, high density lipoprotein, Low density lipoprotein (LDL-C), apolipoprotein A (apo A) and apolipoprotein B (apo B) were divided into three groups according to carotid intima-media thickness: 34 cases in normal carotid artery group, 31 cases in carotid atherosclerosis group, 36 cases in carotid plaque group, 36 cases in carotid artery plaque group, 34 cases in normal carotid artery group, 31 cases in carotid atherosclerosis group and 36 cases in carotid plaque group. The normal group was set as the control group. The serum indexes of the three groups were measured and compared, and the relationship between them and carotid intima media thickness was analyzed. SPSS20.0 was used for statistical analysis. Results there were no significant differences in sex, age, smoking history, drinking history, history of FBGG, TGN, LDL-C and APOAA APOBN BMI between the three groups (P 0.05. 2). There was no significant difference in HDL-C between the three groups. The comparison of HDL-C between the three groups was compared with that of the control group (P < 0.05). The comparison of HDL-C between the three groups was as follows: compared with the control group, there was no significant difference in HDL-C between the three groups. The comparison of the levels of Cyst-c in the sclerosing group and the control group were as follows: the comparison of the levels of P0.05U and UA in the plaque group, the comparison of the HDL-C level in the control group of the plaque group and the control group, the comparison of the levels of HDL-C in the plaque group and the control group. Correlation between Cyst-Con UA and cIMT in the sclerosing control group the positive correlation between Cyst-Con UA and c IMT was 0.334U 0.3170.442 (P = 0.001 0. 001D 0.000) and negative correlation between HDL-C and cIMT was r-0.293P = 0. 003P = 0. 003P = 0. 001 ~ 0. 000 P = 0. 003a, P = 0. 001C = 0. 003a, P = 0. 003a, P = 0. 003a, P = 0. 003a respectively. Conclusion: the serum Hcystatin Cyst-ctrocardia is the risk factor of as. HDL-C is the protective factor of as. Monitoring the changes of serum indexes is valuable for the early intervention and treatment of as disease.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R544.1;R543

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 谷云飛;金軍;張守彥;薛書峰;陳劍鋒;賀慧娟;段卡丹;王靜;邱梅紅;邱春光;;胱抑素C與冠狀動(dòng)脈易損斑塊的相關(guān)性分析[J];現(xiàn)代預(yù)防醫(yī)學(xué);2015年15期

2 羅穎;王麗麗;龍娟;陳綺映;胡偉;;血漿尿酸濃度與冠狀動(dòng)脈粥樣硬化性心臟病嚴(yán)重程度的相關(guān)性[J];嶺南心血管病雜志;2015年04期

3 姜怡鄧;孫煒煒;馬勝超;王菊;鞏慧慧;馬長劍;;內(nèi)皮型一氧化氮合酶基因啟動(dòng)子區(qū)DNA甲基化調(diào)控同型半胱氨酸致內(nèi)皮細(xì)胞損傷的機(jī)制[J];中國動(dòng)脈硬化雜志;2013年02期

4 趙乾;劉蕊;徐振興;朱世明;;H型高血壓患者血漿同型半胱氨酸、硫化氫水平與腦循環(huán)動(dòng)力學(xué)的相關(guān)性[J];山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2013年02期

5 郭炯輝;洪英;;血清胱抑素C在腎臟疾病中的診斷價(jià)值[J];現(xiàn)代預(yù)防醫(yī)學(xué);2012年15期

6 吳振;王顏剛;于江蘇;;尿酸鹽致血管內(nèi)皮細(xì)胞損傷的機(jī)制[J];中國分子心臟病學(xué)雜志;2012年01期

7 楊靜;張曉紅;李從圣;聶開政;;胱抑素C與高血壓頸動(dòng)脈IMT的關(guān)系研究[J];中華全科醫(yī)學(xué);2012年02期

8 周月濤;張愛華;;血清胱抑素C水平與冠狀動(dòng)脈粥樣硬化病變嚴(yán)重程度的相關(guān)性研究[J];疑難病雜志;2011年12期

9 張巖;霍勇;;伴同型半胱氨酸升高的高血壓——“H型”高血壓[J];心血管病學(xué)進(jìn)展;2011年01期

10 孫曉楠,李玉明,郭虹;單純收縮期高血壓患者同型半胱氨酸代謝關(guān)鍵酶基因多態(tài)性相關(guān)因子研究[J];中華心血管病雜志;2003年04期

相關(guān)博士學(xué)位論文 前1條

1 吳建祥;氧化高密度脂蛋白對(duì)內(nèi)皮祖細(xì)胞功能影響及機(jī)制研究[D];第二軍醫(yī)大學(xué);2010年

相關(guān)碩士學(xué)位論文 前1條

1 賈倩;頸動(dòng)脈斑塊局部流體力學(xué)參數(shù)分析及斑塊預(yù)警研究[D];中國人民解放軍醫(yī)學(xué)院;2014年

，

本文編號(hào)：1827574