發(fā)布時(shí)間：2018-04-25 23:10

  本文選題：精神分裂癥 + 心血管疾病��； 參考：《中國神經(jīng)精神疾病雜志》2017年09期

【摘要】：目的探討住院精神分裂癥患者心血管疾病風(fēng)險(xiǎn)特征和預(yù)測精神分裂癥患者未來10年發(fā)生心血管疾病風(fēng)險(xiǎn)。方法隨機(jī)收集住院精神分裂癥患者466例,測定患者組體質(zhì)指數(shù)(body mass index,BMI)、空腹血糖(fasting plasma glucose,FBG)、甘油三酯(triglyceride,TG)、總膽固醇(total cholesterol,TC)、吸煙率(吸煙人數(shù)/總?cè)藬?shù))、高密度脂蛋白(high density lipoprotein-cholesterol,HDL-C)、Framing-ham心血管疾病發(fā)生風(fēng)險(xiǎn)評(píng)分(Framing-ham risk score,FRS)和血管年齡等指標(biāo),并與507例健康對(duì)照進(jìn)行比較。其中10年心血管疾病發(fā)生風(fēng)險(xiǎn)和血管年齡用Framing-ham心血管疾病風(fēng)險(xiǎn)評(píng)分表來計(jì)算。結(jié)果住院精神分裂癥患者未來10年發(fā)生心血管疾病的風(fēng)險(xiǎn)高于對(duì)照組[(6.71%±6.95%)vs.(4.76%±3.07%)],差異有統(tǒng)計(jì)學(xué)意義(P0.05);與對(duì)照組相比,患者組的吸煙率[(41%)vs.(19%)]、代謝綜合征患病率[(25%)vs.(17%)]、BMI水平[(23.67±3.61)kg/m~2 vs.(21.73±4.11)kg/m~2]和血管年齡[(46.7±15.3)歲vs.(43.7±9.8)歲]增加(P0.05);SBP[(119.86±14.90)mmHg vs.(128.10±15.41)mmHg]和HDL-C水平[(1.08±0.27)mmol/L vs.(1.38±0.22)mmol/L]降低(P0.05)�；颊呓M的FRS總分與BMI、FBG、SBP、腰圍及吸煙指數(shù)均呈正相關(guān)(P0.05),與HDL-C呈負(fù)相關(guān)(P0.05)。多因素線性回歸分析示,FRS總分與FBG(β=0.181,P0.01)、SBP(β=0.149,P0.01)、HDL-C(β=-0.107,P0.01)和吸煙指數(shù)(吸煙支數(shù)×吸煙年數(shù))(β=0.554,P0.01)有關(guān)聯(lián)。結(jié)論研究發(fā)現(xiàn)住院精神分裂癥患者未來10年發(fā)生心血管疾病的風(fēng)險(xiǎn)為6.7%,顯著高于對(duì)照組。空腹血糖、收縮壓、高密度脂蛋白、吸煙可能與精神分裂癥患者未來10年發(fā)生心血管疾病有關(guān)聯(lián)。
[Abstract]:Objective to investigate the risk characteristics of cardiovascular disease in inpatients with schizophrenia and to predict the risk of cardiovascular disease in schizophrenic patients in the next 10 years. Methods A total of 466 inpatients with schizophrenia were randomly collected. Body mass index (BMI), fasting plasma glucose (FBG), triglyceride (TG), total cholesterol (TC), smoking rate (number of smokers / total number of people), high density lipoprotein-cholesterol (HDL-C) and Framing-ham cardiovascular disease risk scores (Framing-ham risk scoreFRSs) were measured. The results were compared with 507 healthy controls. Ten-year cardiovascular disease risk and vascular age were calculated using the Framing-ham cardiovascular disease risk scale. Results the risk of cardiovascular disease in inpatients with schizophrenia in the next 10 years was higher than that in the control group (6.71% 鹵6.95% 鹵4.76% 鹵3.07%), and the difference was statistically significant (P 0.05). 鎮(zhèn)ｈ，

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