本文選題：黑加侖籽粉 + 腎性高血壓　； 參考：《新疆醫(yī)科大學(xué)》2015年碩士論文

【摘要】：目的:研究黑加侖籽粉對腎性高血壓大鼠血壓、心臟、腎臟的影響,并探討其降壓機制。方法:制備兩腎一夾腎性高血壓模型,將造模成功大鼠隨機分為模型組、卡托普利組(15mg/kg/d)、牛黃降壓片組(0.208g/kg/d)、黑加侖籽粉低劑量組(1.375g/kg/d)、中劑量組(2.75g/kg/d)、高劑量組(5.5g/kg/d)。另取10只大鼠作為假手術(shù)組。各組大鼠灌胃給藥8周,假手術(shù)組、模型組給予等容量蒸餾水。給藥前及給藥后定期對大鼠血壓進(jìn)行測量,并于末次給藥后,腹主動脈采血,測定大鼠血漿中血管緊張素II(AngII)、內(nèi)皮素(ET)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6-Keto-PGF1α)含量,血清中超氧化物歧化酶(SOD)活力、一氧化氮(NO)、丙二醛(MDA)含量;取心臟、腎臟測定心臟指數(shù)、左心室指數(shù)、腎臟指數(shù)。結(jié)果:給藥8周后,測定大鼠血壓,與模型組相比,黑加侖籽粉各劑量組均能降低腎性高血壓大鼠血壓(P0.01);測定大鼠血中因子,與模型組相比,黑加侖籽粉各劑量組ET、TXB2、MDA含量明顯降低(P0.01或P0.05),NO含量明顯升高(P0.01),黑加侖籽粉中、高劑量組AngII含量明顯降低(P0.01或P0.05),黑加侖籽粉高劑量組6-Keto-PGF1α含量、SOD活力明顯升高(P0.01或P0.05);測定左心室指數(shù),心臟指數(shù),與模型組相比,黑加侖籽粉各劑量組左心室指數(shù)明顯降低(P0.01或P0.05),黑加侖籽粉高劑量組心臟指數(shù)明顯降低(P0.05)。結(jié)論:黑加侖籽粉能降低腎性高血壓大鼠血壓且對其心臟有一定的保護(hù)作用趨勢,推測黑加侖籽粉的降壓途徑可能與通過抗氧化作用來保護(hù)血管內(nèi)皮細(xì)胞,同時調(diào)節(jié)血管舒縮因子,改善血管內(nèi)皮功能有關(guān)。
[Abstract]:Aim: to study the effects of blackcurrant seed powder on blood pressure, heart and kidney in renal hypertensive rats and to explore its mechanism of lowering blood pressure. Methods: two kidney and one clip renal hypertension models were established. Successful rats were randomly divided into three groups: captopril group (15 mg / kg / d), Niuhuang Jiangya tablet group (0.208 g / kg / d), blackcurrant seed powder low dose group (1.375 g / kg / d), middle dose group (2.75 g / kg / d), high dose group (5.5 g / kg / d). Another 10 rats were used as sham-operated group. Rats in each group were given equal volume distilled water for 8 weeks, sham operation group and model group. Blood pressure was measured regularly before and after administration of the drug in rats. Blood samples from abdominal aorta were taken after the last administration. The contents of angiotensin IIAngIIA, endothelin (et), thromboxane B 2 (TXB 2) -6-keto PGF 1 偽 in plasma of rats were measured, and the plasma levels of angiotensin II, endothelin (et) and thromboxane B 2 (TXB 2) -prostaglandin F 1 偽 (6-Keto-PGF 1 偽) were measured. The activity of superoxide dismutase (SOD), the content of nitric oxide (no) and malondialdehyde (MDA) in serum, the heart index, left ventricular index and renal index were measured in the heart and kidney. Results: after 8 weeks of administration, the blood pressure of rats was measured. Compared with the model group, the blood pressure of rats with renal hypertension was decreased in each dose group of blackcurrant seed powder, and the blood factor of rats was measured, compared with the model group. The content of TXB2O MDA in black currant seed powder decreased significantly (P 0.01 or P 0.05%), the content of AngII in high dose group significantly decreased P0.01 or P0.05%, and the activity of 6-Keto-PGF1 偽 in high dose group increased P0.01 or P0.05%, and the left ventricular index was measured, and the content of TXB2O in black currant seed powder was significantly increased, and the content of 6-Keto-PGF1 偽 was significantly increased in high dose group of black currant seed powder, and the activity of 6-Keto-PGF1 偽 was significantly increased in the high dose group of blackcurrant seed powder (P 0.01 or P 0.05). Compared with the model group, the left ventricular index of the blackcurrant seed powder group was significantly lower than that of the model group. The left ventricular index of each dose group was significantly lower than that of the model group, and the heart index of the high-dose black currant seed powder group was significantly lower than that of the control group. Conclusion: blackcurrant seed powder can reduce blood pressure and protect heart in renal hypertensive rats. It is suggested that the antihypertensive pathway of blackcurrant seed powder may be related to the protection of vascular endothelial cells by antioxidation. At the same time, regulating vasomotor factor and improving vascular endothelial function are related.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R544.14

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 朱玉梅,劉玉慶,魯衛(wèi)星;黑加侖油軟膠囊治療原發(fā)性高脂血癥80例對照觀察[J];中國中醫(yī)基礎(chǔ)醫(yī)學(xué)雜志;2003年05期

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