本文選題：慢性心力衰竭 + 抑郁癥　； 參考：《遼寧中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察應(yīng)用開心散治療慢性心力衰竭合并抑郁癥(心脾兩虛證)的臨床療效。方法:收集2016.03-2017.03遼寧中醫(yī)藥大學(xué)附屬第二醫(yī)院心病二科符合慢性心力衰竭合并抑郁癥(心脾兩虛證)納入標(biāo)準(zhǔn)的病房及門診患者60例,按隨機(jī)數(shù)字表法隨機(jī)分為試驗(yàn)組及對照組各30例。對照組予慢性心力衰竭西醫(yī)常規(guī)治療,試驗(yàn)組在對照組常規(guī)治療基礎(chǔ)上加用開心散中藥湯劑口服。28天為1療程。兩組患者均在治療前及治療后測定NT-pro BNP數(shù)值,采用中醫(yī)癥候量化積分表、抑郁量表(SDS)、明尼蘇達(dá)心衰量表進(jìn)行評分,觀察兩種治療方案的臨床治療效果。應(yīng)用SPSS17.0統(tǒng)計軟件對數(shù)據(jù)進(jìn)行分析,計數(shù)資料采用X2檢驗(yàn),計量資料采用T檢驗(yàn),等級資料采用非參數(shù)秩和檢驗(yàn)。結(jié)果:1.中醫(yī)證候療效方面:試驗(yàn)組和對照組治療后,癥狀均有所改善,試驗(yàn)組療效明顯優(yōu)于對照組(P0.05)。2.改善抑郁癥狀方面:兩組治療后(SDS)評分均較治療前減低,試驗(yàn)組減低程度明顯優(yōu)于對照組,差異具有統(tǒng)計學(xué)意義(P0.05)。3.改善心衰癥狀及理化指標(biāo)方面:兩組治療后NT-pro BNP數(shù)值及明尼蘇達(dá)心衰生活質(zhì)量調(diào)查表評分均較治療前降低,試驗(yàn)組減低程度明顯優(yōu)于對照組,差異具有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:1.開心散能夠改善慢性心力衰竭合并抑郁癥(心脾兩虛證)患者的抑郁狀態(tài)和心衰癥狀,提高患者生活質(zhì)量。2.對于慢性心力衰竭合并抑郁的患者,通過對抑郁癥的治療,患者的心衰癥狀可以得到改善,生活質(zhì)量得到明顯提高。
[Abstract]:Objective: to observe the clinical effect of Xinxing Powder in treating chronic heart failure with depression (deficiency of heart and spleen). Methods: a total of 60 patients in the second Department of Heart Disease of the second affiliated Hospital of Liaoning University of traditional Chinese Medicine (Liaoning University of traditional Chinese Medicine) who met the admission criteria of chronic heart failure and depression (heart and spleen deficiency syndrome) were collected. According to the method of random digital table, 30 cases were randomly divided into experimental group and control group. The control group was treated with routine western medicine for chronic heart failure, and the experimental group was treated with the traditional Chinese medicine decoction for 28 days as a course of treatment on the basis of routine treatment in the control group. The NT-pro BNP values were measured before and after treatment in both groups. The clinical effects of the two treatments were evaluated with the quantitative symptom scale of TCM, the depression scale and the Minnesota Heart failure scale. SPSS17.0 statistical software was used to analyze the data. The counting data was tested by X2 test, the measurement data by T test, and the rank data by non-parametric rank sum test. The result is 1: 1. The curative effect of TCM syndrome: after treatment, the symptoms of the experimental group and the control group were improved, and the curative effect of the experimental group was obviously better than that of the control group (P0.05. 2). Improvement of depressive symptoms: after treatment, the scores of SDSs in both groups were lower than those before treatment, and the degree of depression in the experimental group was significantly better than that in the control group, and the difference was statistically significant (P0.05. 3). In terms of improving symptoms and physical and chemical indexes of heart failure, the NT-pro BNP value and the score of Minnesota Heart failure quality of Life questionnaire were lower in the two groups after treatment than before treatment, and the degree of reduction in the trial group was obviously better than that in the control group, and the difference was statistically significant (P 0.05). Conclusion 1. Qiangsan can improve the depression state and symptoms of heart failure in patients with chronic heart failure combined with depression (deficiency of heart and spleen), and improve the quality of life of patients. 2. For patients with chronic heart failure combined with depression, the symptoms of heart failure can be improved and the quality of life can be improved by the treatment of depression.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R541.6;R749.4

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