本文選題：脈搏波傳導(dǎo)速度 + 同型半胱氨酸　； 參考：《蚌埠醫(yī)學(xué)院》2017年碩士論文

【摘要】：目的:探討PWV和血Hcy在老年高血壓患者中的關(guān)系,從而為老年高血壓患者動(dòng)脈硬化性疾病的早期識(shí)別提供有效的監(jiān)測(cè)指標(biāo),為該病的早期防治提供新策略。方法:選擇蚌埠醫(yī)學(xué)院第一附屬醫(yī)院老年病科年齡在60歲以上的老年高血壓患者86例。所有患者均符合《中國(guó)高血壓防治指南》(2010修訂版)的高血壓診斷標(biāo)準(zhǔn),并接受常規(guī)降壓藥物治療,且治療后經(jīng)血壓監(jiān)測(cè)24小時(shí)平均血壓小于140/90mmHg,排除嚴(yán)重的肝腎功能不全的患者。根據(jù)血Hcy水平將86例患者分為兩組:正常組46例,血Hcy≤15μmol/L;升高組40例,血Hcy15μmol/L。分別測(cè)定兩組患者的年齡、性別、體重指數(shù)(body mass index,BMI)、丙氨酸氨基轉(zhuǎn)移酶(Alanine aminotransferase,ALT)、總膽固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、肌酐(Creatinine,Cr)、空腹血糖(Fasting blood glucose,FBG)、糖化血紅蛋白(HbA1c)、Hcy、收縮壓(Systolic blood pressure,SBP)、舒張壓(Diastolic blood pressure,DBP)、PWV等。結(jié)果:1.兩組患者在性別構(gòu)成、合并癥等方面比較差異無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)。2.高同型半胱氨酸組中的BMI、肌酐明顯高于正常組(p0.05);兩組患者的年齡、ALT、總膽固醇、甘油三脂、空腹血糖、糖化血紅蛋白、收縮壓、舒張壓的比較差異無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)。3.正常Hcy組和高Hcy組的Hcy水平分別為(11.73±2.28)μmol/L、(19.81±3.59)μmol/L,兩組Hcy比較差異有統(tǒng)計(jì)學(xué)意義(p0.05);正常Hcy組和高Hcy組的bapwv水平分別為(1657.69±182.37)cm/s、(2013.43±248.91)cm/s,兩組bapwv和Hcy比較差異有統(tǒng)計(jì)學(xué)意義(p0.05)。4.Pearson相關(guān)分析表明,bapwv與Hcy、年齡、BMI、ALT、總膽固醇、甘油三脂、肌酐、空腹血糖、糖化血紅蛋白、SBP、DBP呈正相關(guān)(p0.05);多元線性回歸分析表明bapwv的獨(dú)立危險(xiǎn)因素為年齡、膽固醇、甘油三酯、肌酐、Hcy、SBP等(p0.05)。結(jié)論:在老年高血壓患者中bapwv的增快與高Hcy血癥有正相關(guān)性,積極控制高同型半胱氨酸血癥,對(duì)老年高血壓患者的預(yù)后具有重要意義。
[Abstract]:Objective: to explore the relationship between PWV and blood Hcy in elderly patients with hypertension, so as to provide an effective monitoring index for the early identification of arteriosclerotic diseases in elderly patients with hypertension, and to provide a new strategy for early prevention and treatment of the disease. Methods: 86 elderly hypertensive patients aged over 60 years were selected from the geriatrics department of the first affiliated Hospital of Bengbu Medical College. All the patients were in accordance with the criteria of hypertension diagnosis and treatment, and were treated with conventional antihypertensive drugs. After treatment, the mean blood pressure was less than 140 / 90mm / g in 24 hours after treatment, and the patients with severe liver and kidney dysfunction were excluded. According to the serum Hcy level, 86 patients were divided into two groups: normal group (46 cases), blood Hcy 鈮，

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