發(fā)布時(shí)間：2018-04-19 12:42

  本文選題：基質(zhì)金屬蛋白酶-9 + 心房重構(gòu)　； 參考：《河北醫(yī)科大學(xué)》2017年碩士論文

【摘要】：基質(zhì)金屬蛋白酶-9(matrix metalloproteinase-9,MMP-9)是基質(zhì)金屬蛋白酶大家族中的重要組成成員,屬于明膠酶類(lèi),又稱(chēng)明膠酶B,具有降解與重塑細(xì)胞外基質(zhì)(extracellular matrix,ECM)的作用。ECM又是心臟的重要組成部分,起支持和固定心臟的作用。正常情況下,ECM是相對(duì)穩(wěn)定的。當(dāng)心血管疾病發(fā)生時(shí),MMP-9的表達(dá)量的變化使ECM的調(diào)節(jié)發(fā)生異常,使ECM的合成和降解失去平衡,引起ECM內(nèi)成分的比例變化,影響ECM的正常的支持、信息傳遞等功能,使心臟表現(xiàn)出病理形態(tài),失去心臟正常的生理功能,并產(chǎn)生多種并發(fā)癥。在心臟中,ECM的降解對(duì)心臟重塑過(guò)程有重要影響,主要表現(xiàn)為細(xì)胞和心臟失去支持和固定,當(dāng)心腔內(nèi)壓力升高時(shí)心肌細(xì)胞延伸,心腔擴(kuò)大,心臟功能發(fā)生障礙,在心房中可以表現(xiàn)為心房壁變薄,心房擴(kuò)大,正常的心房細(xì)胞成分減少,心房間質(zhì)發(fā)生廣泛纖維化,最終促進(jìn)和維持心房重構(gòu)的發(fā)生和發(fā)展。心房擴(kuò)大和心房間質(zhì)纖維化是心房結(jié)構(gòu)重構(gòu)的主要表現(xiàn)。由此可見(jiàn)MMP-9在心房重構(gòu)中有重要作用。1 MMP-9不僅參與正常的生理過(guò)程如血管形成、創(chuàng)傷愈合、再生、胚胎發(fā)育等,而且在心血管疾病(如房顫、心力衰竭、二尖瓣疾病、心肌梗死等)發(fā)生、發(fā)展的病理過(guò)程中對(duì)心房結(jié)構(gòu)重構(gòu)也有重要影響。2通過(guò)抑制MMP-9的表達(dá)可以抑制心房重構(gòu),是治療心血管疾病的一個(gè)重要方向。
[Abstract]:Matrix metalloproteinase-9 (MMP-9) is an important member of the matrix metalloproteinase-9 family. It belongs to gelatinases, also known as gelatinase B, and has the function of degradation and remodeling extracellular matrix metalloproteinase-9 (ECM). ECM is also an important part of the heart.To support and fix the heart.Under normal conditions, ECM is relatively stable.When cardiovascular disease occurs, the changes of MMP-9 expression make the regulation of ECM abnormal, make the synthesis and degradation of ECM out of balance, cause changes in the proportion of components in ECM, affect the normal support of ECM, information transmission and other functions.Make the heart show pathological form, lose the normal physiological function of the heart, and produce a variety of complications.The degradation of ECM in the heart plays an important role in the process of cardiac remodeling, which is characterized by the loss of support and fixation of cells and the heart.In the atrium, the atrial wall becomes thinner, the atrium expands, the normal atrial cell component decreases, the atrial interstitial fibrosis occurs, and the atrial remodeling is promoted and maintained.Atrial enlargement and atrial interstitial fibrosis are the main manifestations of atrial structural remodeling.It can be seen that MMP-9 plays an important role in atrial remodeling. 1 MMP-9 not only participates in normal physiological processes such as angiogenesis, wound healing, regeneration, embryonic development, but also in cardiovascular diseases (such as atrial fibrillation, heart failure, mitral valve disease, etc.)The occurrence and development of myocardial infarction have an important influence on atrial structural remodeling. 2 it can inhibit atrial remodeling by inhibiting the expression of MMP-9, which is an important direction in the treatment of cardiovascular diseases.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R54

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本文編號(hào)：1773142