本文選題：銀杏酮酯分散片 + 冠心病穩(wěn)定型心絞痛�。� 參考：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:評(píng)價(jià)銀杏酮酯分散片在冠心病穩(wěn)定型心絞痛(心血瘀阻證)的治療中對(duì)改善心絞痛癥狀、中醫(yī)證候、心電圖以及硝酸甘油停減率等方面的有效性及安全性。方法:試驗(yàn)觀察運(yùn)用隨機(jī)、雙盲、陽(yáng)性藥對(duì)照的方法,選擇2016年3月到2016年11月在黑龍江中醫(yī)藥大學(xué)附屬第一醫(yī)院心內(nèi)三就診患者,診斷符合入組標(biāo)準(zhǔn)并且自愿同意進(jìn)行試驗(yàn)觀察的60例心臟病患者。隨機(jī)的將患者分為治療組(口服銀杏酮酯分散片,1片/次,每日3次,口服金納多模擬劑,1片/次,每日3次)32例和對(duì)照組(口服金納多,1片/次,每日3次,口服銀杏酮酯分散片模擬劑,1片/次,每日3次)28例,用藥8W±2d,結(jié)束后觀察銀杏酮酯分散片治療胸痹心痛(心血瘀阻證)在中醫(yī)證候、心絞痛癥狀、心電圖以及硝酸甘油停減率方面的療效。結(jié)果:1.心絞痛癥狀方面,對(duì)照組的總有效率達(dá)67.86%,治療組的總有效率達(dá)93.75%,兩組患者有效率經(jīng)秩和檢驗(yàn)P0.05,有統(tǒng)計(jì)學(xué)差異。2.在中醫(yī)證候評(píng)分方面,治療組和對(duì)照組患者治療前后中醫(yī)證候評(píng)分變化均有顯著性差異(P0.05),中醫(yī)證候療效方面,對(duì)照組的總有效率達(dá)71.43%,治療組的總有效率達(dá)93.75%,兩組患者中醫(yī)證候療效經(jīng)秩和檢驗(yàn)P0.05,存在統(tǒng)計(jì)學(xué)差異。3.在硝酸甘油停減率方面,對(duì)照組的總有效率達(dá)71.43%,治療組的有效率達(dá)93.75%,兩組患者經(jīng)秩和檢驗(yàn)P0.05,有統(tǒng)計(jì)學(xué)差異。4.在心絞痛發(fā)作次數(shù)方面,治療后治療組與對(duì)照組經(jīng)配對(duì)t檢驗(yàn)P0.05,差異有統(tǒng)計(jì)學(xué)意義。在心絞痛發(fā)作持續(xù)時(shí)間方面,治療組和對(duì)照組治療后心絞痛發(fā)作持續(xù)時(shí)間均減少,前后進(jìn)行配對(duì)t檢驗(yàn)P0.05,差異具有統(tǒng)計(jì)學(xué)意義。5.在心電圖改善方面,對(duì)照組的總有效率達(dá)35.71%,治療組的有效率達(dá)50%,兩組患者有效率經(jīng)秩和檢驗(yàn)P0.05,差異不具有統(tǒng)計(jì)學(xué)意義。6.兩組肝、腎功指標(biāo)經(jīng)配對(duì)t檢驗(yàn)比較,治療組和對(duì)照組治療前后均無(wú)顯著差異(P0.05)。結(jié)論:1.銀杏酮酯分散片具有改善冠心病穩(wěn)定型心絞痛(心血瘀阻證)病人心絞痛癥狀以及降低中醫(yī)證候積分的作用。2.銀杏酮酯分散片可以改善冠心病穩(wěn)定型心絞痛(心血瘀阻證)患者的心電圖表現(xiàn)。3.銀杏酮酯分散片能夠減少冠心病穩(wěn)定型心絞痛(心血瘀阻證)患者硝酸甘油的使用量。4.銀杏酮酯分散片在實(shí)驗(yàn)進(jìn)程中無(wú)不良反應(yīng)的發(fā)生。
[Abstract]:Objective: To evaluate the Ginkgo biloba dispersible tablets on coronary heart disease with stable angina (blood stasis syndrome) in the treatment to improve the symptoms of angina pectoris, TCM syndrome, efficacy and safety of ECG, nitroglycerin withdrawal rate etc.. Methods: experimental observation using randomized, double-blind, positive drug control method March 2016, to November 2016 in the First Affiliated Hospital of Heilongjiang University Of Chinese Medicine in three patients, diagnosis and voluntarily agreed to meet the standard set of 60 patients with heart diseases were observed. The patients were randomly divided into treatment group (oral Ginkgo biloba dispersible tablets, 1 tablets each time, 3 times daily oral Ginaton analog., 1 tablets each time, 3 times daily) 32 cases and control group (oral Ginaton, 1 tablets each time, 3 times daily oral Ginkgo biloba dispersible tablets analog agent, 1 tablets each time, 3 times daily) in 28 cases, use 8W + 2D, after the observation of Ginkgo biloba Dispersible Tablets Treatment Chest pain (blood stasis syndrome) in TCM syndrome, symptoms of angina, ECG and nitroglycerin stop reduction rate of the curative effect. Results: 1. angina symptoms, the total effective rate of control group was 67.86%, the total effective rate of treatment group was 93.75%, two groups of patients with efficiency by rank sum test P0.05 there is significant difference in.2., TCM syndrome score, the treatment group and the control of TCM syndrome score were significantly different group of patients before and after treatment (P0.05), TCM syndrome curative effect, the total effective rate of control group was 71.43%, the total efficiency of the treatment group was 93.75%, two groups of TCM Syndrome curative effect the rank and inspection of P0.05, there were significant differences in.3. withdrawal rate of nitroglycerin, control group the total effective rate was 71.43%, the effective rate of treatment group was 93.75%, two groups of patients by rank test P0.05, there were significant differences in.4. frequency of angina pectoris, treatment The paired t test P0.05 group and control group after treatment treatment, there were statistically significant differences in the duration of angina pectoris, treatment group and control group after treatment of angina pectoris were reduced in duration, paired t test before and after P0.05, the difference was statistically significant.5. in electrocardiogram improvement, the total effective rate of the control group the 35.71%, the effective rate of treatment group was 50%, two groups of patients with efficiency by rank test P0.05, the difference was not statistically significant.6. two groups of liver, renal function index compared with the paired t test, treatment group and control group before and after treatment showed no significant difference (P0.05). Conclusion: with improved stability coronary heart disease angina pectoris 1. Ginkgo biloba dispersible tablets (blood stasis syndrome) in patients with angina symptoms and reduce the effects of Ginkgo biloba extract.2. TCM dispersible tablets can improve coronary heart disease with stable angina (blood stasis syndrome) in patients with ECG .3. ginkgo ketone dispersible tablets can reduce the use of nitroglycerin in patients with stable angina pectoris (heart blood stasis syndrome)..4. ginkgo ketone dispersible tablets had no adverse reactions in the experimental process.

【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R541.4

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