本文選題：微突T支架技術(shù)　切入點(diǎn)：冠狀動(dòng)脈分叉　出處：《第三軍醫(yī)大學(xué)學(xué)報(bào)》2017年10期

【摘要】：目的建立兔腹主動(dòng)脈分叉雙支架術(shù)模型。方法雄性新西蘭兔5只(體質(zhì)量3.0~3.5 kg),麻醉消毒后,經(jīng)頸動(dòng)脈途徑于腹主動(dòng)脈-髂動(dòng)脈血管分叉處采用邊支支架微突T支架技術(shù)(T-stenting and small protrusion,TAP)實(shí)施雙支架植入術(shù),利用數(shù)字減影血管造影(digital subtraction angi-ography,DSA)、血管內(nèi)超聲(intravascular ultrasound,IVUS)和顯微CT掃描(micro computed tomography,micro-CT)進(jìn)行術(shù)后即刻評(píng)價(jià)及術(shù)后6個(gè)月復(fù)查。結(jié)果可通過(guò)兔頸動(dòng)脈放置6F鞘管,于腹主動(dòng)脈分叉處成功實(shí)施TAP雙支架術(shù),術(shù)后即刻DSA提示支架位置滿(mǎn)意,血流TIMI 3級(jí),IVUS提示支架貼壁良好,術(shù)后6個(gè)月復(fù)查DSA提示無(wú)支架內(nèi)再狹窄及血栓形成,血流TIMI 3級(jí),IVUS提示支架貼壁良好,無(wú)支架內(nèi)再狹窄,micro-CT可見(jiàn)邊支開(kāi)口處支架覆蓋完全,無(wú)支架內(nèi)血栓,右側(cè)髂動(dòng)脈支架下緣微突入腹主動(dòng)脈管腔[(0.49±0.08)mm]。結(jié)論成功建立了兔腹主動(dòng)脈分叉雙支架術(shù)模型,為冠脈分叉病變的臨床前期研究提供了依據(jù)。
[Abstract]:Objective to establish a double stenting model of abdominal aorta bifurcation in rabbits. Methods five male New Zealand rabbits (3.0 ~ 3.5 kg / kg) were anesthetized and disinfected. T-stenting and small protrusions were performed by T-stenting at the branch of abdominal aorta-iliac artery via carotid artery via T-stenting and small tamponade (TAP). Digital subtraction angiography (digital subtraction angi-choreography), intravascular ultrasound (IVUS) and microCT scanning micro computed tomographic micro-CTs were used for immediate evaluation and reexamination at 6 months after operation. Results 6 F sheath tubes could be placed in the carotid artery of rabbits. TAP double stents were successfully performed at the abdominal aorta bifurcation. Immediately after operation, DSA indicated satisfactory stenting position, blood flow grade 3 TIMI + IVUS indicated good stenting, 6 months after operation DSA indicated no stent restenosis and thrombus formation. TIMI 3 TIMI showed that the stents were adherent well, without restenosis in the stents, the stents were completely covered at the opening of the lateral branches by micro-CT, and there was no thrombus in the stents. The right iliac artery stent was microprojected into the abdominal aortic lumen [0.49 鹵0.08)mm]. Conclusion A rabbit model of double stenting of abdominal aorta bifurcation was successfully established, which provides a basis for the clinical study of coronary artery bifurcation.
【作者單位】： 第三軍醫(yī)大學(xué)新橋醫(yī)院心血管內(nèi)科 全軍心血管病研究所;
【基金】：國(guó)家自然科學(xué)基金面上項(xiàng)目(81370213,81670428)~~
【分類(lèi)號(hào)】：R-332;R543.1
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本文編號(hào)：1698238