發(fā)布時間：2018-03-23 10:55

  本文選題：脂氧合酶　切入點：同型半胱氨酸　出處：《重慶醫(yī)學》2017年34期

【摘要】：目的研究血清5-脂氧合酶(5-LO)、同型半胱氨酸(Hcy)與頸動脈粥樣硬化(CAS)斑塊穩(wěn)定性的關系。方法收集云南省第三人民醫(yī)院經(jīng)頸動脈超聲診斷為CAS的患者共176名,并根據(jù)頸動脈超聲結果分為穩(wěn)定斑塊組及易損斑塊組;另收集同期該院體檢中心體檢并經(jīng)由頸動脈超聲排除CAS的健康志愿者108名為對照組;檢測各組5-LO、Hcy的血清水平,并進行比較探討兩者與CAS斑塊穩(wěn)定性的關系;通過Logistic回歸分析探討CAS的危險因素并通過繪制ROC曲線探討5-LO、Hcy預測頸動脈粥樣硬化斑塊穩(wěn)定性的意義。結果 5-LO、Hcy在易損斑塊組均較穩(wěn)定斑塊組及對照組高,差異有統(tǒng)計學意義(P0.05);穩(wěn)定斑塊組Hcy水平較對照組高(P0.05),而5-LO水平與對照組比較差異無統(tǒng)計學意義(P0.05);Logistic回歸分析發(fā)現(xiàn)5-LO、Hcy、糖尿病是CAS的危險因素(P0.05)。ROC曲線提示以232.89pg/mL水平為臨界值,血清5-LO水平預測斑塊穩(wěn)定性的敏感性為84.4%,特異度為81.8%;以12.53μmol/L為臨界值,血清Hcy水平預測斑塊穩(wěn)定性的敏感性為70.1%,特異度為66.7%。結論血清5-LO及Hcy是預測CAS斑塊穩(wěn)定性的危險因素;調節(jié)二者水平可能成為臨床穩(wěn)定CAS的潛在靶點。
[Abstract]:Objective to study the relationship between serum 5-lipoxygenase (5-LOX) and plaque stability in carotid atherosclerosis. Methods 176 patients with CAS diagnosed by transcarotid ultrasound in the third people's Hospital of Yunnan Province were collected. According to the results of carotid ultrasound, 108 healthy volunteers were divided into stable plaque group and vulnerable plaque group, 108 healthy volunteers who were examined by physical examination center and excluded from CAS by carotid ultrasound in the same period were collected as control group, and the serum levels of 5-LOHcy were measured in each group. The relationship between them and the stability of CAS plaque was compared. The risk factors of CAS were analyzed by Logistic regression analysis and the significance of 5-LOHcy in predicting the stability of carotid atherosclerotic plaques was studied by drawing ROC curve. Results the levels of 5-LOHcy in vulnerable plaque group were higher than those in stable plaque group and control group. The level of Hcy in stable plaque group was higher than that in control group (P 0.05), but there was no significant difference in 5-LO level between control group and control group. Logistic regression analysis showed that 5-LOA Hcy. diabetes was a risk factor of CAS. The curve of P0.05? ROC suggested that 232.89pg/mL level was the critical value. The sensitivity of serum 5-LO level to predicting plaque stability was 84.4, the specificity was 81.8, the critical value of serum Hcy was 12.53 渭 mol/L, the sensitivity of serum Hcy level to predicting plaque stability was 70.1 and the specificity was 66.7. Conclusion Serum 5-LO and Hcy are risk factors for predicting plaque stability of CAS. Regulation of both levels may be a potential target for clinically stable CAS.
【作者單位】： 云南省第三人民醫(yī)院神經(jīng)內科;昆明醫(yī)科大學第一附屬醫(yī)院老年神經(jīng)內科;四川大學華西醫(yī)院神經(jīng)內科;
【基金】：云南省第三人民醫(yī)院/大理學院昆明直屬醫(yī)院院內課題(YJ201204)
【分類號】：R543.4

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本文編號：1653153