本文選題：高血壓　切入點(diǎn)：腦白質(zhì)損害　出處：《中華高血壓雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的研究高血壓患者腦白質(zhì)病變程度與直立性低血壓(OH)的關(guān)系。方法選擇2014年3月至2015年1月在西安交通大學(xué)第一附屬醫(yī)院神經(jīng)內(nèi)科及心內(nèi)科門診、住院的經(jīng)過(guò)磁共振成像檢查無(wú)腦卒中的原發(fā)性高血壓患者。測(cè)量臥位、立位血壓,以臥位轉(zhuǎn)為立位3min內(nèi)收縮壓下降≥20和(或)舒張壓下降≥10mm Hg為OH。使用Fazekas量表評(píng)估腦白質(zhì)病變,其中0~3分為無(wú)/輕度腦白質(zhì)病變,4~6分為重度腦白質(zhì)病變。結(jié)果患者225例重度腦白質(zhì)病變59例(26.2%),符合OH標(biāo)準(zhǔn)49例(21.8%)。OH組重度腦白質(zhì)病變發(fā)生率高于非OH組(51.0%比19.3%,P0.01)。OH組腦白質(zhì)病變?cè)u(píng)分高于非OH組(3.67±1.03比2.55±1.27,P0.05)。多因素分析顯示,與腦白質(zhì)病變相關(guān)的因素有:年齡(OR=3.347,95%CI 1.140~9.833,P=0.028)、高血壓病程(OR=1.121,95%CI1.064~1.181,P0.001)、臥位舒張壓(1.059,95%CI 1.015~1.105,P=0.008)和OH(OR=3.637,95%CI1.539~8.590,P=0.003)。結(jié)論 OH與高血壓患者腦白質(zhì)病變呈正相關(guān),OH可能是高血壓促進(jìn)腦白質(zhì)病變的機(jī)制之一。
[Abstract]:Objective to study the relationship between the degree of cerebral white matter lesion and orthostatic hypotension in patients with hypertension. Methods from March 2014 to January 2015, we selected the Department of Neurology and Cardiology, first affiliated Hospital of Xi'an Jiaotong University, from March 2014 to January 2015. Inpatients with essential hypertension without stroke examined by magnetic resonance imaging. Blood pressure in supine position, standing position, The Fazekas scale was used to evaluate the white matter lesions with systolic blood pressure 鈮，

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