發(fā)布時間：2018-03-17 13:01

  本文選題：心舒寧合劑　切入點：舒張性心力衰竭　出處：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年19期 　論文類型：期刊論文

【摘要】：目的探討心舒寧合劑輔助治療舒張性心力衰竭(DHF)患者的臨床效果及對患者外周血腦鈉肽(BNP)、糖類抗原125(CA125)和C反應(yīng)蛋白(CRP)的影響。方法選取2015年1~12月該院心血管內(nèi)科收治的DHF患者120例,根據(jù)就診順序隨機分為心舒寧組和常規(guī)組各60例。兩組均采用西醫(yī)基礎(chǔ)治療,心舒寧組同時給予心舒寧合劑輔助治療,療程2個月,對比臨床效果。結(jié)果治療后,心舒寧組與常規(guī)組比較,6 min步行距離、心臟彩超E峰/A峰和左室射血分數(shù)均高于常規(guī)組,差異有統(tǒng)計學(xué)意義(t=3.767、3.866和5.474,P=0.000、0.000和0.000);心舒寧組的等容舒張時間低于常規(guī)組,差異有統(tǒng)計學(xué)意義(t=8.36,P=0.000);心舒寧組外周血BNP、CA125和CRP水平低于常規(guī)組,差異有統(tǒng)計學(xué)意義(t=3.456、6.317和6.939,P=0.003、0.000和0.000);治療2個月后,心舒寧組的總有效率95.00%(57/60)高于常規(guī)組81.67%(49/60),差異有統(tǒng)計學(xué)意義(χ2=5.175,P=0.023)。結(jié)論心舒寧合劑輔助治療DHF患者能夠提高患者的心功能水平,降低外周血BNP、CA125和CRP水平,提高臨床治療效果。
[Abstract]:Objective to investigate the clinical effect of Xinshuning mixture in the treatment of patients with diastolic heart failure (DHFV) and its effects on the patients with peripheral blood brain natriuretic peptide (BNPP), carbohydrate antigen 125 (CA125) and C-reactive protein (CRP). Methods from 2015 to December, the patients were selected from the Department of Cardiovascular Medicine in our hospital. 120 patients with DHF, According to the order of visit, the patients were randomly divided into two groups: Xinshuning group (n = 60) and routine group (n = 60). Both groups were treated with basic western medicine, and Xinxuning mixture was treated with Xinxuning mixture for 2 months. Compared with the control group, the walking distance at 6 min, peak E / A and left ventricular ejection fraction in Xinshuning group were higher than those in the routine group, and the difference was statistically significant (P < 0.05), and the isovolumic diastolic time of Xinxuning group was lower than that of the routine group. The levels of BNPCA125 and CRP in the peripheral blood of Xinshuning group were lower than those in the routine group, and the differences were statistically significant. The total effective rate of Xinshuning group (95.00 / 60) was significantly higher than that of the routine group (81.67 / 49 / 60) (蠂 ~ 2 / 5.175). Conclusion the cardiac function of patients with DHF treated with Xinshuning mixture can improve the level of cardiac function, decrease the levels of BNPCA125 and CRP in peripheral blood, and improve the clinical therapeutic effect.
【作者單位】： 貴陽中醫(yī)學(xué)院第一附屬醫(yī)院心血管內(nèi)科;
【分類號】：R541.6

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本文編號：1624844