本文選題：冠心病　切入點：網(wǎng)膜素-1　出處：《南華大學》2015年碩士論文　論文類型：學位論文

【摘要】：目的：探究血清網(wǎng)膜素-1與冠心病的發(fā)生、冠脈病變程度及斑塊穩(wěn)定性的關系。方法：選取2013年10月至2014年3月因“胸痛、心悸、胸悶”收入南華大學附屬第一醫(yī)院心內科住院的患者110例,并行冠狀動脈造影(Coronary angiography,CAG)檢查,其中冠心病(Coronary heart disease)患者90例及對照組20例。記錄110例研究對象的性別、年齡、吸煙史、體重、身高、收縮壓(SBP)及舒張壓(DBP)。將90例CHD患者分為急性心肌梗死(AMI)組28例、穩(wěn)定型心絞痛(SAP)組28例及不穩(wěn)定型心絞痛(UAP)組34例；根據(jù)冠脈造影結果將患者分為單支病變組(36例)、雙支病變組(32例)、多支病變組(22例)。入院第二天清晨空腹(禁食、禁飲8h以上)抽血檢測110例研究對象的空腹血糖(FBG)、總膽固醇(TC)、甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)及高密度脂蛋白膽固醇(HDL-C),并采用酶聯(lián)免疫吸附試驗法檢測其血清Omentin-1和MMP-9水平,將檢測結果進行統(tǒng)計學分析。結果：(1)各組臨床相關資料包括性別、年齡、BMI、FBG、TC、TG、LDL-C比較,差異無統(tǒng)計學意義(P0.05)。AMI組、SAP組及UAP組中HDL-C水平明顯低于對照組,而收縮壓、舒張壓水平均高于對照組,差異均具有統(tǒng)計學意義(P0.05)。AMI組、SAP組及UAP中HDL-C.SBP、DBP水平相比較,無顯著性差異(P0.05)。(2)AMI組、SAP組及UAP組中患者血清Omentin-1水平均顯著低于對照組,MMP-9水平均顯著高于對照組(P0.05),且AMI組患者血清Omentin-1水平明顯低于SAP組及UAP組(P0.05),AMI組患者MMP-9水平明顯高于SAP組及UAP組(P0.05)。(3)多支病變組血清Omentin-1水平低于雙支病變組,雙支病變組血清Omentin-1水平低于單支病變組,單支病變組血清Omentin-1水平低于對照組,差異均有統(tǒng)計學意義(P0.05)；而多支病變組MMP-9水平高于雙支病變組(P0.05),雙支病變組MMP-9水平高于單支病變組(P0.05),單支病變組MMP-9水平高于對照組(P0.05)；(4)血清Omentin-1水平與BMI、FPG、TG、TC、LDL-C呈負相關(相關系數(shù)r分別為-0.174、-0.254、-0.227、-0.141、-0.213),與HDL-C呈正相關(r=0.244,P=0.021),而與年齡、SBP、DBP均無明顯的相關性(P0.05)：(5)血清Omentin-1水平和MMP-9水平呈顯著負相關(r=0.686,P0.05)。結論：血清Omentin-1水平與冠心病、冠心病的嚴重程度及斑塊穩(wěn)定性有關,有可能成為判斷冠心病嚴重程度的指標之一。
[Abstract]:Objective: to investigate the relationship between serum omentin-1 and coronary heart disease, severity of coronary artery disease and plaque stability. Methods: from October 2013 to March 2014, patients with chest pain and palpitation were selected. 110 patients admitted to the Department of Cardiology of the first affiliated Hospital of South China University underwent coronary angiographic examination, including 90 patients with coronary heart disease and 20 patients in the control group. The sex, age and smoking history of 110 patients were recorded. 90 patients with CHD were divided into acute myocardial infarction (AMI) group (n = 28), stable angina pectoris group (n = 28) and unstable angina pectoris group (n = 34). According to the results of coronary angiography, the patients were divided into single vessel lesion group (n = 36), double vessel lesion group (n = 32) and multivessel lesion group (n = 22). Fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured in 110 subjects. The serum levels of Omentin-1 and MMP-9 were measured by enzyme linked immunosorbent assay (Elisa). Results the clinical data of each group, including sex, age and age, showed that there was no significant difference in the level of HDL-C between SAP group and UAP group, but the systolic blood pressure (SBP) was significantly lower in SAP group and UAP group than in control group. The levels of DBP in SAP group and UAP group were significantly higher than those in control group. There was no significant difference in serum Omentin-1 levels between SAP group and UAP group. The serum Omentin-1 level in AMI group was significantly lower than that in control group (P 0.05), and the MMP-9 level in AMI group was significantly lower than that in SAP group and UAP group (P 0.05). The serum Omentin-1 level in SAP group and UAP group was lower than that in double vessel lesion group. The level of serum Omentin-1 in double vessel group was lower than that in single vessel group, and the level of serum Omentin-1 in single vessel lesion group was lower than that in control group. The level of MMP-9 in multivessel lesion group was higher than that in double vessel lesion group, the level of MMP-9 in double vessel lesion group was higher than that in single vessel lesion group, and the MMP-9 level in single vessel lesion group was higher than that in control group (P 0.05). The correlation numbers r were -0.174U -0.254U -0.227U -0.141U -0.213g, which were positively correlated with HDL-C 0.244P 0.021, but had no significant correlation with age SBPnP. There was no significant negative correlation between serum Omentin-1 level and MMP-9 level. Conclusion: serum Omentin-1 level is negatively correlated with coronary heart disease, and there is no significant correlation between serum Omentin-1 level and MMP-9 level. Conclusion: serum Omentin-1 level is negatively correlated with coronary heart disease (CHD), and there is a significant negative correlation between Omentin-1 level and MMP-9 level (P < 0.05), conclusion: serum Omentin-1 level has a negative correlation with coronary heart disease, and no significant correlation is found between Omentin-1 level and MMP-9 level. The severity of coronary heart disease is related to plaque stability, which may be one of the indexes to judge the severity of coronary heart disease.
【學位授予單位】：南華大學
【學位級別】：碩士
【學位授予年份】：2015
【分類號】：R541.4

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