發(fā)布時間：2018-02-09 10:39

  本文關鍵詞： 嗜酸性粒細胞 hs-CRP 冠脈病變 預后　出處：《山西醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:通過檢測冠心病(Coronary artery disease,CHD)患者外周血嗜酸性粒細胞(EOS)計數(shù)及超敏C反應蛋白(hs-CRP)水平,探討外周血EOS計數(shù)及hs-CRP水平與冠脈病變及預后的關系。方法:挑選了自2016年5月-2016年10月山大一院心血管內科CCU病區(qū)收治的冠心病患者112例作為觀察組,同期非冠心病患者66例為正常對照組,測定其入院外周血EOS計數(shù)及hs-CRP水平,比較兩組外周血EOS計數(shù)及hs-CRP的水平;將冠心病患者按照冠脈狹窄程度及病變支數(shù)分組,分析外周血EOS計數(shù)及hs-CRP水平與冠脈病變程度及支數(shù)的關系。再將冠心病患者組分為AMI組、UA組、SAP組,比較各組間外周血EOS計數(shù)、hs-CRP水平變化情況。對冠心病組患者隨訪3個月,記錄MACE事件的發(fā)生情況。結果:冠心病組中AMI組患者外周血EOS計數(shù)水平低于UA組、SAP組及正常對照組,hs-CRP水平明顯高于UA組、SAP組及正常對照組(P㩳0.05,表2)。冠脈狹窄重度組EOS計數(shù)水平與輕度狹窄組相比有統(tǒng)計學差異(P㩳0.05,表3)。冠脈病變重度及中度狹窄組hs-CRP水平明顯高于輕度狹窄組,組間比較有統(tǒng)計學差異(P㩳0.05,表3),且hs-CRP水平與狹窄程度呈正相關(r=0.345,P㩳0.01);外周血EOS計數(shù)及hs-CRP水平在冠脈病變支數(shù)分組中無統(tǒng)計學差異(均P㧐0.05)。采用多因素Logistic回歸分析結果顯示hs-CRP(OR=1.385,95%CI:1.077~1.781,P=0.011)、aTnI(OR=1.336,95%CI:1.067~1.674,P=0.011)、NT-proBNP(OR=1.002,95%CI:1.077~1.781,P=0.011)是影響患者近期MACE的危險因素。結論:外周血EOS計數(shù)與hs-CRP水平與冠脈病變之間存在相關性,hs-CRP水平越高,冠脈病變越嚴重;AMI患者外周血EOS計數(shù)水平會降低;hs-CRP對冠心病患者近期預后有預測意義。
[Abstract]:Objective: to detect the eosinophil count and the level of hypersensitive C-reactive protein (hs-CRP) in peripheral blood of patients with coronary artery disease (CHD). To investigate the relationship between peripheral blood EOS count, hs-CRP level and coronary artery disease and prognosis. Methods: from May 2016 to October 2016, 112 patients with coronary heart disease (CHD) in CCU ward of Department of Cardiovascular Medicine, Shanshan University first Hospital, were selected as the observation group. In the same period, 66 patients with non-coronary heart disease were taken as the normal control group, the EOS count and hs-CRP level in the admission peripheral blood were measured, and the EOS count and hs-CRP level in the peripheral blood of the two groups were compared, and the coronary heart disease patients were grouped according to the degree of coronary stenosis and the number of diseased branches. To analyze the relationship between EOS count and hs-CRP level in peripheral blood and the severity and number of coronary artery disease, the patients were divided into AMI group (UA group) and AMI group (UA group) to compare the changes of EOS count and hs-CRP level in each group. The patients in coronary heart disease group were followed up for 3 months. Results: the level of EOS in peripheral blood in AMI group was lower than that in UA group and normal control group, which was significantly higher than that in UA group and normal control group. 0. 05, Table 2. The EOS count level in severe coronary stenosis group was significantly higher than that in mild stenosis group. The level of hs-CRP in severe and moderate stenosis group was significantly higher than that in mild stenosis group. The level of hs-CRP was positively correlated with the degree of stenosis. There was no significant difference in EOS count and hs-CRP level in coronary artery disease group (all P? The results of multivariate Logistic regression analysis showed that hs-CRP OR1. 385 / 95: CI1: 1.077 1.781PnIOR1: 0.01111 TnIOR1. 336CIQ: 1. 6767 + 1. 674% P0. 01111 was the risk factor of MACE in the patients. Conclusion: the higher the EOS count in peripheral blood and the higher the level of hCRP in peripheral blood and coronary artery disease, the higher the hs-CRP level is, and the higher the correlation between EOS count in peripheral blood and the level of hs-CRP and coronary artery disease is higher, the higher the correlation between the EOS count in peripheral blood and the coronary artery disease, the higher the hs-CRP level is, and the higher the correlation is between the EOS count in peripheral blood and the coronary artery disease, and the higher the correlation between the EOS count in peripheral blood and the coronary artery disease. The more serious the coronary artery disease, the lower the level of EOS in peripheral blood of patients with coronary artery disease, and the lower the level of hs-CRP, which can predict the short-term prognosis of patients with coronary heart disease.
【學位授予單位】：山西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R541.4

【參考文獻】

相關期刊論文 前10條

1 黃勇先;郭俊瑾;朱曉明;徐艷;;血清降鈣素原和超敏C反應蛋白與非ST段抬高急性冠脈綜合征危險分層的相關性研究[J];遼寧醫(yī)學雜志;2016年06期

2 羅紅;李友錢;;冠心病患者血清降鈣素原、超敏C反應蛋白水平變化及其與冠狀動脈斑塊的相關性研究[J];實用心腦肺血管病雜志;2016年04期

3 李重偉;張福;李燕玲;高奮堂;高志凌;何勤利;謝萍;;降鈣素原和超敏C反應蛋白與急性冠脈綜合征患者GRACE評分的相關性及其對預后的評估價值[J];中國現(xiàn)代醫(yī)藥雜志;2015年12期

4 顏文華;李新華;趙曉燕;武麗娜;;冠狀動脈粥樣硬化性心臟病患者血清降鈣素原水平與冠狀動脈斑塊成分的相關性分析[J];中國現(xiàn)代醫(yī)學雜志;2015年33期

5 施瑩;鐘澤仲;楊子聰;薛焱;劉伶;;嗜酸性粒細胞與急性冠脈綜合征患者支架內再狹窄的相關性[J];實用醫(yī)學雜志;2015年22期

6 班麗素;陳郁;張文玲;王曉菲;張晨晰;張立文;;嗜酸性粒細胞計數(shù)與冠心病危險因素相關分析[J];標記免疫分析與臨床;2015年07期

7 鄧建君;周川;謝萍;侯婷婷;蘇鵬;何勤利;高奮堂;;血清降鈣素原與急性心肌梗死患者炎癥反應的相關性研究[J];中國循環(huán)雜志;2015年04期

8 李嬌;李新明;柳亮;王溫慧;叢欣鵬;侯士強;;血清HMGB1和hs-CRP水平與冠心病嚴重程度的相關性分析[J];中國動脈硬化雜志;2015年02期

9 劉志祥;謝飛;吳玉竹;李文兵;;血清降鈣素原、超敏C反應蛋白與冠狀動脈粥樣硬化病變程度的關系[J];國際檢驗醫(yī)學雜志;2014年04期

10 楊紅慶;姜文錫;梅換明;杜小琴;;纖維蛋白原與超敏C反應蛋白在冠心病患者中的表達與意義[J];中國老年學雜志;2013年21期

相關碩士學位論文 前2條

1 徐秀良;嗜酸性粒細胞陽離子蛋白與冠狀動脈粥樣硬化性心臟病的相關性分析[D];福建醫(yī)科大學;2012年

2 谷麗娟;2型糖尿病及糖尿病腎病患者血清1，，25-二羥維生素D_3水平的觀察[D];南昌大學;2011年

本文編號：1497737