本文關(guān)鍵詞： 骨髓腔 棕色脂肪細胞 白色脂肪細胞 免疫組織化學(xué)　出處：《臨床與實驗病理學(xué)雜志》2017年07期 　論文類型：期刊論文

【摘要】：目的探討骨髓腔內(nèi)棕色脂肪細胞增生性病變的臨床病理學(xué)特征。方法回顧性分析2例骨髓腔內(nèi)棕色脂肪細胞增生臨床和影像學(xué)資料、病理組織學(xué)形態(tài)、免疫表型及隨訪資料。結(jié)果 2例患者年齡分別為64歲和49歲,男女各1例,例1伴椎間盤突出,病變位于L4椎體和椎弓根處;例2無明顯不適,病變位于左脛骨中段。CT示均為髓腔內(nèi)邊界不清、密度不均的高密度影,骨皮質(zhì)未見侵犯。組織學(xué)上髓腔內(nèi)見圓形或多邊形細胞散在或成簇分布于成熟脂肪組織內(nèi),胞質(zhì)豐富,內(nèi)含多個小脂滴,間質(zhì)內(nèi)富含薄壁血管,髓腔內(nèi)骨小梁未見異常。免疫表型:多空泡細胞UCP1、S-100均呈陽性,CKpan、CD68、Calcitonin、PRLR均呈陰性。隨訪1年,患者均無復(fù)發(fā)。結(jié)論棕色脂肪細胞增生在骨髓腔內(nèi)報道較少,腫瘤患者術(shù)后行18F-FDG PET/CT掃描復(fù)查時需注意與棕色脂肪組織鑒別。
[Abstract]:Objective to investigate the clinicopathological features of brown adipocyte hyperplasia in medullary cavity. Methods the clinical and imaging data and histopathological features of 2 cases of brown adipocyte hyperplasia in medullary cavity were analyzed retrospectively. Results the age of the two patients was 64 years old and 49 years old, male and female were 1 case, case 1 with disc herniation, the lesion was located at L4 vertebral body and pedicle. In case 2, there was no obvious discomfort. The lesion was located in the middle part of left tibia. Ct showed that the intramedullary boundary was not clear and the density was uneven. Histologically, round or polygonal cells were scattered or clustered in mature adipose tissue, rich in cytoplasm, containing many small lipid droplets, and rich in parenchyma. No abnormal bone trabeculae were found in the medullary cavity. Immunophenotype: UCP1 / S-100 cells were all positive for CKpan-CD68 and Calcitonin. PRLR was negative and no recurrence was found in the patients after one year follow-up. Conclusion Brown adipocyte proliferation is rarely reported in the medullary cavity. After operation, 18 F-FDG PET/CT scan should be used to differentiate tumor patients from brown adipose tissue.
【作者單位】： 安徽省池州市人民醫(yī)院病理科;安徽省池州市人民醫(yī)院骨科;
【分類號】：R551.3
【正文快照】： 棕色脂肪組織(brown adipose tissue,BAT)主要見于嬰幼兒和兒童,分布于肩胛間區(qū)、腋窩、頸后部(血管和肌肉的周圍)、肺門、縱隔和腹腔內(nèi)(特別是腎、胰和脾周圍),隨著年齡增長而逐漸消失。采用18F-FDG PET/CT掃描成人AT,發(fā)現(xiàn)在頸部、鎖骨上區(qū)、脊柱兩側(cè)、縱隔、腎周及腎上腺等，

本文編號：1484006