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  本文關(guān)鍵詞： 阿托伐他汀 心肌缺血/再灌注 ATP酶 大鼠 白細(xì)胞介素-(IL-) 腫瘤壞死因子-α(TNF-α) 心肌梗死　出處：《西安交通大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年03期 　論文類型：期刊論文

【摘要】：目的探討阿托伐他汀的不同用藥方式對心肌缺血/再灌注(myocardial ischemia/reperfusion,MI/R)損傷的影響及機制。方法建立SD大鼠在體MI/R模型。160只大鼠隨機分為MI/R組、MI/R+阿托伐他汀常規(guī)劑量(MI/R+N)組、MI/R+術(shù)前單次負(fù)荷劑量(MI/R+SL)組、MI/R+術(shù)前連續(xù)負(fù)荷劑量(MI/R+ML)組,并設(shè)假手術(shù)(Sham)組。Evans blue/TTC雙染色測定心肌梗死面積;檢測心肌ATP酶活性及血清白細(xì)胞介素-6(IL-6)和腫瘤壞死因子-α(TNF-α)水平;小動物超聲測定左室射血分?jǐn)?shù)(LVEF%)。結(jié)果與MI/R+N組比較,MI/R+SL組和MI/R+ML組的心肌梗死面積明顯減少(P0.05),心肌ATP酶活性明顯增高(P0.05),血清IL-6和TNF-α水平明顯減低(P0.05),MI/R后24hLVEF%顯著改善(P0.05)。而MI/R+SL組和MI/R+ML組間的心肌梗死面積、心肌ATP酶活性、IL-6和TNF-α水平、LVEF%的差異無統(tǒng)計學(xué)意義。結(jié)論負(fù)荷劑量阿托伐他汀可通過改善心肌ATP代謝,減少炎癥因子異常表達等機制,減輕MI/R損傷。術(shù)前單次負(fù)荷劑量與術(shù)前連續(xù)負(fù)荷劑量的用藥方式對保護MI/R無差別。
[Abstract]:Objective to investigate the effects of different drug methods of Atto vastatin on myocardial ischemia / reperfusion myocardial ischemia/reperfusion. Methods the MI/R model of SD rats in vivo was established. 160 rats were randomly divided into MI/R group. The routine dose of MI/R Atto vastatin was given to the MIP / R group, and the single load dose before MIR / R was given to the MIP / R group. The area of myocardial infarction was determined by continuous load dose before MI/R and sham group. Evans blue/TTC double staining was used to measure myocardial infarction area. Myocardial ATP enzyme activity, serum interleukin-6 (IL-6) and tumor necrosis factor- 偽 (TNF- 偽) were measured. Left ventricular ejection fraction (LVEF) was measured by ultrasound in small animals. Results compared with MI/R N group, myocardial infarction size in MIP / R SL group and MI/R ML group was significantly reduced (P 0.05). The activity of ATP in myocardium increased significantly (P 0.05), and the levels of serum IL-6 and TNF- 偽 decreased significantly (P 0.05). 24 h after MI/R, LVEF% significantly improved the myocardial infarct size and myocardial ATP enzyme activity between MI/R SL group and MI/R ML group. There was no significant difference between IL-6 and TNF- 偽 levels in LVEF%. Conclusion Atto vastatin can improve myocardial ATP metabolism and reduce the abnormal expression of inflammatory factors. There was no difference between preoperative single load dose and preoperative continuous load dose in protecting MI/R.
【作者單位】： 西安交通大學(xué)第一附屬醫(yī)院心內(nèi)科;陜西省中醫(yī)醫(yī)院;陜西省核工業(yè)二一五醫(yī)院;
【基金】：國家自然科學(xué)基金項目資助(No.81370357;No.81570381)~~
【分類號】：R542.2
【正文快照】： 缺血/再灌注(myocardial ischemia/reperfusion,MI/R)損傷是經(jīng)皮冠狀動脈介入治療(PCI)缺血性心肌病時常見的心肌代謝功能障礙,也是隨著PCI廣泛開展而亟需解決的重點問題[1-2]。作為新一代他汀類藥物,阿托伐他汀的抗炎性、抗細(xì)胞凋亡、免疫調(diào)節(jié)作用等多重藥理效應(yīng)使其在MI/R損

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