本文關(guān)鍵詞：中國(guó)易栓人群抗凝蛋白缺陷與血栓形成易感性的研究　出處：《中國(guó)人民解放軍醫(yī)學(xué)院》2016年碩士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 易栓癥 抗凝血酶缺陷癥 下肢靜脈血栓 肺栓塞 抗凝蛋白 腦梗

【摘要】：目的：研究中國(guó)人群靜脈血栓栓塞癥及腦�；颊逷C、PS、AT活性水平,分析這三種抗凝蛋白與靜脈血栓形成的相關(guān)性及分析中國(guó)人群靜脈血栓患者的易栓因素。方法：選擇2014年1月至2015年1月來(lái)解放軍總醫(yī)院就診的靜脈血栓栓塞癥及腦�；颊吖�168例,分析其年齡分布,血栓形成部位,并分別檢測(cè)其PC、PS、AT活性水平;同時(shí)選擇50名健康查體人員作為對(duì)照組,檢測(cè)其PC、PS、AT活性水平,與病例組作對(duì)照。結(jié)果：四十到五十歲是靜脈血栓和腦梗的集中高發(fā)年齡,占23.2%。下肢靜脈是靜脈血栓栓塞癥患者最易受累部位,下肢靜脈血栓在每個(gè)年齡所占比例均超過(guò)50%。靜脈血栓栓塞癥患者組與正常對(duì)照組比較,三種抗凝蛋白差異均有統(tǒng)計(jì)學(xué)意義,p值均0.01。腦梗患者組與正常對(duì)照組比較,PS、PC兩項(xiàng)活性水平差異有統(tǒng)計(jì)學(xué)意義,p值均0.05,AT活性水平差異無(wú)統(tǒng)計(jì)學(xué)意義,p值0.05。靜脈血栓栓塞癥患者組與腦�；颊呓M比較,三種抗凝蛋白差異均無(wú)統(tǒng)計(jì)學(xué)意義,p值均0.05。結(jié)論：AT、PS、PC三種抗凝蛋白均是靜脈血栓栓塞癥的易感因素；PS、PC兩種抗凝蛋白也是腦梗的易感因素。在臨床中,抗凝蛋白檢測(cè)越來(lái)越受到廣大臨床醫(yī)生的認(rèn)可,其活性水平可以為血栓性疾病的預(yù)防和診斷提供及時(shí)可靠的有力依據(jù)。目的：探討檢測(cè)AT:A、AT:Ag、PS、PC、D-二聚體等凝血易栓指標(biāo)對(duì)診斷遺傳性抗凝血酶缺陷癥的臨床價(jià)值。方法：選擇42例抗凝血酶缺陷癥患者作為疾病組,再根據(jù)PS、PC水平將疾病組進(jìn)一步分為單純AT缺乏組(27例)、AT聯(lián)合PS缺乏組(6例)、AT聯(lián)合PC缺乏組(3例)和AT、PS、PC全缺乏組(6例)；選擇60例健康查體人員作為健康對(duì)照組。用發(fā)色底物法檢測(cè)兩組患者血漿AT：A及PC、PS活性,用免疫比濁法檢測(cè)兩組患者血漿AT:Ag及血漿D-二聚體濃度。采用獨(dú)立樣本的t檢驗(yàn)比較各組間差異。結(jié)果：AT缺陷癥組患者AT：A和AT:Ag水平明顯減低,與健康對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(AT:At=-11.68, P0.01; AT:Agt=-6.118, P0.01); AT聯(lián)合PS、PC缺乏患者的PS、PC水平明顯減低,與健康對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(PS t=-9.397,p0.01; PC t=-3.065,P0.01);AT缺陷癥組患者血漿D-二聚體水平明顯增高,與健康對(duì)照組比較差異有統(tǒng)計(jì)學(xué)意義(t=4.358,P0.01)。結(jié)論：AT缺陷是靜脈血栓栓塞性疾病的主要遺傳性危險(xiǎn)因素,檢測(cè)其相關(guān)凝血指標(biāo)有助于疾病的早期診斷,為臨床提供診療依據(jù),對(duì)預(yù)防VTE的發(fā)生起到了預(yù)警作用。
[Abstract]:Objective: To study the Chinese population of venous thromboembolism in patients with cerebral infarction and PC, PS, AT activity level, the analysis of the three kinds of anticoagulant proteins and venous thrombosis and correlation analysis of thrombophilia factors of venous thrombosis in patients with Chinese population. Methods: from January 2014 to January 2015 to the Liberation Army General hospital for treatment of venous thromboembolism and cerebral infarction patients a total of 168 cases, analysis of the age distribution, thrombosis parts, and to detect their PC, PS, AT activity level; and 50 healthy people as control group, to detect the PC, PS, AT activity, compared with the case group. Results: Forty to 50 is high age vein thrombosis and cerebral infarction, accounting for 23.2%. of lower limb vein in patients with venous thromboembolism is the most easily affected parts, lower extremity venous thrombosis in each age accounted for the proportion of more than 50%. in patients with venous thromboembolism group and normal control group Comparison of three kinds of anticoagulant protein differences were statistically significant, P value compared with the normal control group were 0.01. patients with cerebral infarction PS group, the difference was statistically significant PC two activity level, P value was 0.05, there were no significant differences in AT activity level of 0.05. in patients with venous thromboembolism group and cerebral infarction patients group P value. Three kinds of anticoagulant proteins had no significant difference, P values were 0.05. AT, PS PC, conclusion: the three kinds of anticoagulant proteins are venous thromboembolism risk factors; PS, the predisposing factors of PC two kinds of anticoagulant proteins in clinical cerebral infarction. Also, anticoagulant protein detection has been more and more recognized by the majority of clinicians the level of activity, can provide a strong basis for reliable and timely diagnosis and prevention of thrombotic diseases. Objective: To investigate the detection of AT:A, AT:Ag, PS, PC, D- two dimers coagulation thrombophilic index clinical value for diagnosis of hereditary antithrombin deficiency syndrome. Methods: 42 cases of antithrombin deficiency patients as the disease group, according to PS, the PC level will be further divided into simple disease group AT deficiency group (27 cases), AT combined with PS deficiency group (6 cases), AT combined with PC deficiency group (3 cases) and AT, PS, PC deficiency group (6); 60 cases of patients with healthy people as healthy control group. Using chromogenic assay in two groups AT:A and PC, PS activity, with immunoturbidimetry in two groups of patients with plasma AT:Ag and plasma D- two concentration. Independent samples t test was used to compare the difference between groups. Results: AT deficiency in patients with AT:A and AT:Ag was significantly reduced, and health was significantly lower than the control group (AT:At=-11.68, P0.01; AT:Agt=-6.118, P0.01; AT) combined with PS, PC deficiency in patients with PS, PC was significantly reduced, and health was significantly lower than the control group (PS t=-9.397, PC t=-3.065, P0.01; P0.01) ; AT deficiency patients plasma D- two level of D-dimer increased significantly, and health was significantly lower than the control group (t=4.358, P0.01). Conclusion: AT defect is the major genetic risk factors of venous thromboembolic disease, early diagnosis and its related coagulation parameters contribute to disease, provide the basis for clinical diagnosis and treatment. The role of early warning to prevent the occurrence of VTE.

【學(xué)位授予單位】：中國(guó)人民解放軍醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R543.6

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