艾滋病相關(guān)腹瀉67例臨床分析
本文關(guān)鍵詞:艾滋病相關(guān)腹瀉67例臨床分析
【摘要】:目的了解高效抗逆轉(zhuǎn)錄病毒治療(highly active antiretroviral therapy,HAART)廣泛應(yīng)用時(shí)代艾滋病相關(guān)腹瀉(HIV/AIDS related diarrhea,HRD)的臨床特點(diǎn)。方法回顧性分析67例HRD患者的艾滋病(acquired immunodeficiency syndrome,AIDS)病程、發(fā)病誘因、疾病診斷、免疫功能等。結(jié)果 79.20%的患者感染人類免疫缺陷病毒(human immunodeficiency virus,HIV)病程超過10年,約86.50%患者腹瀉病程大于3個(gè)月,65.60%的患者診斷為藥物相關(guān)性腹瀉。31例患者CD4~+T淋巴細(xì)胞50~350/μL,32例患者CD4~+T淋巴細(xì)胞350/μL。結(jié)論 HAART時(shí)代,HRD患者HIV感染史長(zhǎng),以腸道免疫損傷、菌群異位等非感染性慢性腹瀉臨床常見,含LPV/r的二線治療方案可增加其發(fā)生的危險(xiǎn),外周血CD4~+T淋巴細(xì)胞數(shù)高者腹瀉發(fā)生率也高。
【作者單位】: 河南中醫(yī)學(xué)院第一附屬醫(yī)院艾滋病臨床研究中心;國(guó)家中醫(yī)藥管理局中醫(yī)傳染病學(xué)重點(diǎn)學(xué)科;鄭州市中醫(yī)院;
【關(guān)鍵詞】: 艾滋病 腹瀉
【基金】:國(guó)家中醫(yī)藥管理局基地科研專項(xiàng)(JDZX2012021)
【分類號(hào)】:R512.91;R574.62
【正文快照】: 艾滋病又稱獲得性免疫缺陷綜合征,是因感染HIV造成的以全身免疫系統(tǒng)進(jìn)行性破壞為特征的傳染性疾病。截至2015年7月,我國(guó)報(bào)告存活的HIV/AIDS約55.4萬。腹瀉是艾滋病病程中極易出現(xiàn)的臨床癥狀,艾滋病相關(guān)腹瀉(HIV/AIDS relat-ed diarrhea,HRD)顯著降低患者的生活質(zhì)量,是HIV/AIDS
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