發(fā)布時(shí)間：2021-12-02 10:53

　　AIM To assess the effect of sodium selenite on the severity of dextran sulfate sodium（DSS）-induced colitis in C57BL/6 mice.METHODS Mice were randomly divided into four groups（n = 10/group）: normal group, selenium（Se） group, chronic colitis group, and Se + chronic colitis group. The mice were sacrificed on day 26. Survival rates, clinical symptoms, colon length, and histological changes were determined. The percentages and absolute numbers of immune system cells in the lamina propria lymphocytes（... 

【文章來源】：World Journal of Gastroenterology. 2017,23(21)SCI

【文章頁數(shù)】：14 頁

【文章目錄】：
INTRODUCTION
MATERIALS AND METHODS
    Experimental animals
    Induction of chronic DSS colitis
    Experimental design
    Disease activity index and histopathology
    Cell preparation, culture, and stimulation
    Enzyme-linked immunosorbent assay
    RNA extraction and real-time polymerase chain reaction
    Flow cytometry
    Statistical analysis
RESULTS
    Sodium selenite ameliorates the severity of DSS-induced chronic colitis
    Cytokine production by LPL
    m RNA expression in colon tissue
    Flow cytometry analysis of LPL populations in mouse colon
    Cytokine production by T-LPL cells in mice
DISCUSSION
COMMENTS
    Background
    Research frontiers
    Innovations and breakthroughs
    Applications
    Peer-review


【參考文獻(xiàn)】：
期刊論文
[1]Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice[J]. Jun Yao,Cheng Wei,Jian-Yao Wang,Ru Zhang,Ying-Xue Li,Li-Sheng Wang.  World Journal of Gastroenterology. 2015(21)



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