【摘要】：目的觀察血清丙氨酸氨基轉(zhuǎn)移酶(ALT)水平升高非酒精性脂肪性肝病(NAFLD)患者代謝相關(guān)指標(biāo)變化。方法 NAFLD患者1 273例,將其中256例血清ALT水平40 U/L者作為ALT升高組,256例血清ALT水平≤40 U/L者作為ALT正常組,同時選取256例非NAFLD者作為對照組。比較三組BMI、收縮壓(SBP)、舒張壓(DBP)、血清尿酸(UA)、TG、TC、LDL-C、HDL-C、空腹血糖(FPG),比較ALT升高組與ALT正常組超重及肥胖、高血壓、高尿酸血癥、高脂血癥、高血糖患病率,分析NAFLD患者血清ALT水平升高的危險因素。結(jié)果 NAFLD患者ALT升高組TC、LDL-C、FPG水平及高脂血癥、高血糖患病率均高于ALT正常組(P均0.05)。多因素Logistic回歸分析結(jié)果顯示,高LDL-C(P=0.000,95%CI:1.358~2.807)和高血糖(P=0.001,95%CI:1.366~3.386)均為NAFLD患者血清ALT水平升高的獨(dú)立危險因素。結(jié)論血清ALT水平升高NAFLD患者TC、LDL-C、FPG水平高,高脂血癥、高血糖患病率高,危險因素為高LDL-C和高血糖。
[Abstract]:Objective to observe the changes of metabolism related indexes in patients with non-alcoholic fatty liver disease (NAFLD) with elevated serum alanine aminotransferase (ALT) level. Methods 1273 patients with NAFLD were enrolled in this study. 256 patients with serum ALT level 40 U 鈮，

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