【摘要】：目的:探討藥物性肝損害的致病藥物及特點(diǎn)。方法:對(duì)某院2003-2013年期間的279例藥物性肝損害進(jìn)行回顧性分析。結(jié)果:在279例藥物性肝損害患者中,男性140人,女性139人,嚴(yán)重肝功能損害50例;聯(lián)合用藥93例,單一用藥186例�；颊呒膊》N類包括腫瘤、呼吸系統(tǒng)感染、代謝綜合征等。其中,藥物性肝損害中肝細(xì)胞損害型占62%(173例)。懷疑藥物196種,其中中藥占17.81%,抗腫瘤藥占16.44%,心血管藥占10.68%,抗結(jié)核藥占10.41%。最常見懷疑藥物包括異煙肼、利福平、甲巰咪唑、雷公藤片�？鼓[瘤、抗結(jié)核與非甾體抗炎藥物參與聯(lián)合用藥時(shí)藥物性肝損發(fā)生例數(shù)多于單用。結(jié)論:易引發(fā)藥物性肝損害的藥物有中藥類、抗菌藥物類、抗腫瘤藥物、抗心血管藥物與抗結(jié)核藥物。聯(lián)合用藥對(duì)藥物性肝損發(fā)生有一定的影響,值得人們進(jìn)一步開展研究。
[Abstract]:Objective: to investigate the pathogenic drugs and characteristics of drug-induced liver damage. Methods: a retrospective analysis of 279 cases of drug-induced liver damage in a hospital from 2003 to 2013 was carried out. Results: among 279 patients with drug-induced liver damage, 140 were male, 139 were female, 50 were severe liver function damage, 93 were combined therapy, 186 were single drug therapy. The types of diseases included tumor, respiratory infection, metabolic syndrome and so on. Of them, 62% (173 cases) had hepatic cell damage. Among 196 suspected drugs, Chinese medicine accounted for 17.81%, antineoplastic drugs 16.44%, cardiovascular drugs 10.68 and anti-tuberculosis drugs 10.41%. The most common suspected drugs include isoniazid, rifampicin, methimazole, and tripterygium wilfordii tablets. There were more cases of drug-induced liver damage when combined use of anti-tumor, anti-tuberculosis and non-steroidal anti-inflammatory drugs. Conclusion: the drugs that can easily cause drug-induced liver damage are Chinese medicine, antimicrobial, antitumor, anticardiovascular and antituberculous. Combined use of drugs has a certain effect on the occurrence of drug-induced liver damage, which is worthy of further study.
【作者單位】： 南京醫(yī)科大學(xué)第一附屬醫(yī)院藥學(xué)部;
【基金】：江蘇高校優(yōu)勢(shì)學(xué)科建設(shè)工程資助項(xiàng)目(編號(hào):XJ10231801)
【分類號(hào)】：R575

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