【摘要】：目的觀察益生菌聯合四聯補救療法作為根除幽門螺桿菌失敗后二線治療輔助方案的臨床療效。方法將165例幽門螺桿菌首次根除治療失敗且經胃鏡和病理學檢查證實的胃十二指腸潰瘍患者隨機分入3組,每組55例。預防用藥組、鞏固用藥組分別在標準四聯療法的前后給予雙歧三聯活菌制劑治療,對照組僅予標準四聯療法治療,3組患者均給予保護胃黏膜治療。所有患者于停藥1個月后復查胃鏡和~(14)C呼氣試驗。比較3組患者的幽門螺桿菌根除率、臨床癥狀改善總有效率、潰瘍愈合率和不良反應發(fā)生率。結果預防用藥組、鞏固用藥組的幽門螺桿菌根除率分別為86.5%(45/52)和88.7%(47/53),均顯著高于對照組的68.0%(34/50,P值均0.05);潰瘍愈合率分別為88.5%(46/52)和88.7%(47/53),均顯著高于對照組的70.0%(35/50,P值均0.05);不良反應率分別為11.5%(6/52)和11.3%(6/53),均顯著低于對照組的30.0%(15/50,P值均0.05)。預防用藥組與鞏固用藥組間的幽門螺桿菌根除率、潰瘍愈合率和不良反應發(fā)生率,以及3組間的臨床癥狀改善總有效率的差異均無統計學意義(P值均0.05)。結論兩種含益生菌的四聯補救療法均能提高幽門螺桿菌首次根除治療失敗的患者的幽門螺桿菌根除率和潰瘍愈合率,并能降低不良反應發(fā)生率。
[Abstract]:Objective to observe the clinical effect of probiotics combined with tetralogy as a second-line therapy for the eradication of Helicobacter pylori. Methods 165 patients with gastroduodenal ulcer confirmed by gastroscopy and pathology were randomly divided into 3 groups, 55 patients in each group. The prophylaxis group and the consolidation group were treated with bifidobacterium triplex before and after the standard tetralogy, while the control group were treated only with standard tetralogy, and the patients in the three groups were treated with gastric mucosal protection. All patients were examined with gastroscopy and 14 C breath test 1 month after withdrawal. The rate of eradication of Helicobacter pylori, the total effective rate of clinical symptom improvement, the rate of ulcer healing and the incidence of adverse reactions were compared among the three groups. Results the prophylaxis group, The eradication rate of Helicobacter pylori was 86.5% (45 / 52) and 88.7% (47 / 53), respectively, which was significantly higher than that of the control group (68.0%) (P < 0.05), the ulcer healing rate was 88.5% (46 / 52) and 88.7% (47r53), respectively, which was significantly higher than that of the control group (70.0%) (35 / 50 P = 0.05), and the adverse reaction rate was 11.5% (6/ 52) and 11.3% (653), respectively. It was significantly lower than the control group (P = 30.0%, P = 0.05). There was no significant difference in the eradication rate of Helicobacter pylori, the rate of ulcer healing and the incidence of adverse reactions, and the total effective rate of improvement of clinical symptoms between the three groups (P < 0.05). Conclusion both two probiotic tetralogy treatments can increase the rate of HP eradication and ulcer healing in patients who failed in the first eradication of Helicobacter pylori, and can reduce the incidence of adverse reactions.
【作者單位】： 上海市第八人民醫(yī)院消化內科;
【分類號】：R57

【相似文獻】

相關期刊論文 前10條

1 謝方彥;張?zhí)m君;;痢特靈治療十二指腸球部潰瘍的療效觀察[J];武漢醫(yī)學雜志;1990年01期

2 程志剛;;雷貝拉唑三聯療法根除幽門螺旋桿菌感染療效觀察[J];浙江中醫(yī)藥大學學報;2007年04期

3 趙殿蓮,賈振英,鄭秋艷;雷尼替丁加甲硝唑治療十二指腸球部潰瘍療效觀察[J];中國綜合臨床;1999年05期

4 代文潔,孫e，

本文編號：2273682