部分消化道疾病患者血清過敏原的臨床研究
發(fā)布時(shí)間：2018-10-14 16:12
【摘要】：目的：分析慢性胃炎、腸易激綜合征、腸息肉三種消化道疾病患者血清過敏原特異性IgE抗體的檢測(cè)結(jié)果，探討過敏因素與上述三種消化道疾病有無關(guān)聯(lián)。 方法：選取2012年5月至2014年4月于大連醫(yī)科大學(xué)附屬第一醫(yī)院消化內(nèi)科住院患者150例。150例患者經(jīng)臨床確診慢性胃炎55例，腸易激綜合征35例，腸息肉60例。其中慢性胃炎診斷標(biāo)準(zhǔn)依據(jù)胃鏡診斷及病理診斷，腸易激綜合征診斷依據(jù)羅馬Ⅲ IBS診斷標(biāo)準(zhǔn)，腸息肉的診斷依據(jù)腸鏡檢查和腸黏膜活檢病理診斷。對(duì)照組為同一時(shí)期于我院體檢的健康人150例。采用歐蒙印跡法，對(duì)消化道疾病患者及健康人進(jìn)行血清20種常見過敏原特異性IgE抗體檢測(cè)，分析過敏因素與上述三種消化道疾病有無關(guān)聯(lián)，應(yīng)用SPSS16.0軟件統(tǒng)計(jì)分析。 結(jié)果： 1、三種消化道疾病共150例患者與對(duì)照組150例健康人共300例血清過敏原特異性IgE抗體檢測(cè)結(jié)果提示：樹組合、普通豚草、艾蒿、塵螨組合、屋塵、貓毛、狗上皮、蟑螂、霉菌組合、雞蛋白、花生、黃豆、牛肉、海魚組合、淡水魚組合、蝦及蟹的特異性IgE抗體檢測(cè)結(jié)果為陽(yáng)性；律草、羊肉、牛奶的特異性IgE抗體檢測(cè)結(jié)果為陰性。 2、三種消化道疾病共150例患者與對(duì)照組150例健康人血清過敏原特異性IgE抗體檢測(cè)結(jié)果依據(jù)濃度分類構(gòu)成比比較,對(duì)照組150例健康人血清過敏原特異性IgE抗體檢測(cè)結(jié)果，陰性占87.33%，特異性IgE抗體濃度達(dá)到1-2級(jí)占12.67%，特異性IgE抗體濃度≥3級(jí)占0%�；颊呓M150例患者血清過敏原特異性IgE抗體檢測(cè)結(jié)果，，陰性占42.67%，特異性IgE抗體濃度達(dá)到1-2級(jí)占34.67%，特異性IgE抗體濃度達(dá)到3級(jí)占10.67%，特異性IgE抗體濃度≥4級(jí)占12.00%。 3、三種消化道疾病共150例患者與對(duì)照組150例健康人血清過敏原特異性IgE抗體陽(yáng)性率比較：150例患者血清過敏原特異性IgE抗體陽(yáng)性率(57.33%）明顯高于對(duì)照組150例健康人（13.33%），兩者比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。血清過敏原特異性IgE抗體陽(yáng)性率最高的為腸易激綜合征患者，其后依次為腸息肉患者及慢性胃炎患者,以上三種消化道疾病患者血清過敏原特異性IgE抗體陽(yáng)性率與對(duì)照組比較差異均有統(tǒng)計(jì)學(xué)意義（P＜0.05）。 4、三種消化道疾病共150例患者與對(duì)照組150例健康人血清吸入性過敏原特異性IgE抗體陽(yáng)性率比較：患者組塵螨組合、狗上皮、蟑螂及樹組合的血清特異性IgE抗體陽(yáng)性率明顯高于對(duì)照組，兩者比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05），患者組中特異性IgE抗體陽(yáng)性率最高的吸入性過敏原為塵螨組合。 5、三種消化道疾病共150例患者與對(duì)照組150例健康人血清食入性過敏原特異性IgE抗體陽(yáng)性率比較：患者組蟹、海魚組合、淡水魚組合、雞蛋白、蝦及黃豆的血清特異性IgE抗體陽(yáng)性率明顯高于對(duì)照組，兩者比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）,患者組中特異性IgE抗體陽(yáng)性率最高的食入性過敏原為蟹。 6、三種消化道疾病共150例患者不同濃度水平血清吸入性過敏原特異性IgE抗體陽(yáng)性率顯示：在1級(jí)-2級(jí)水平，陽(yáng)性率最高的過敏原為塵螨組合，在3級(jí)水平，陽(yáng)性率最高的過敏原為塵螨組合，在≥4級(jí)水平，陽(yáng)性率最高的過敏原為塵螨組合。 7、三種消化道疾病共150例患者不同濃度水平血清食入性過敏原特異性IgE抗體陽(yáng)性率顯示：在1級(jí)-2級(jí)水平，陽(yáng)性率最高的過敏原為蟹，在3級(jí)水平，陽(yáng)性率最高的過敏原為海魚組合，在≥4級(jí)水平，陽(yáng)性率最高的過敏原為蟹。 8、三種消化道疾病患者血清過敏原特異性IgE抗體檢測(cè)結(jié)果陽(yáng)性率兩兩比較：腸易激綜合征患者血清過敏原特異性IgE抗體陽(yáng)性率高于慢性胃炎患者，兩者比較差異有統(tǒng)計(jì)學(xué)意義（P＜0.05）。 9、不同性別患者血清過敏原特異性IgE抗體檢測(cè)結(jié)果的陽(yáng)性率比較：男性患者血清過敏原特異性IgE抗體陽(yáng)性率為56.72%，女性患者血清過敏原特異性IgE抗體陽(yáng)性率為57.83%，兩者比較差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）。 結(jié)論：慢性胃炎、腸易激綜合征、腸息肉三種消化道疾病患者均具有較高的血清過敏原特異性IgE抗體檢測(cè)陽(yáng)性率，其中血清過敏原特異性IgE抗體檢測(cè)陽(yáng)性率最高的吸入性過敏原為塵螨組合,血清過敏原特異性IgE抗體檢測(cè)陽(yáng)性率最高的食入性過敏原為蟹，過敏因素與上述三種消化道疾病有一定關(guān)聯(lián),該研究結(jié)果為今后進(jìn)一步干預(yù)治療提供一定的依據(jù)。
[Abstract]:Objective: To study the detection results of serum allergen-specific IgE antibody in patients with chronic gastritis, irritable bowel syndrome and intestinal polyp. Methods: 150 patients were selected from May 2012 to April 2014 in the First Affiliated Hospital of Dalian Medical University. 150 patients were diagnosed with chronic gastritis in 55 cases, irritable bowel syndrome in 35 cases, intestinal polyp 6. The diagnostic criteria for chronic gastritis were based on gastroscopy and pathological diagnosis, and the diagnosis of irritable bowel syndrome was based on the criteria of diagnosis of IBS, and the diagnosis of intestinal polyps was based on enteroscopy and biopsy of intestinal mucosa. Diagnosis: The control group was the healthy people in our hospital for the same period of 15 years. In 0 cases, 20 kinds of common allergen specific IgE antibody tests were carried out in patients with digestive tract diseases and healthy people by Western blot, and the correlation between allergic factors and the three kinds of digestive tract diseases was analyzed, and SPSS1.6. 0 software statistics were applied. Analysis. Results: There were 300 serum allergen-specific IgE antibody test results in 150 patients with digestive tract diseases and 150 healthy people in control group. The specific IgE antibody detection result of the combination of mold, egg white, peanut, soybean, beef, beef, fresh water fish, shrimp and crab is positive; the specific IgE antibody of the law grass, mutton and milk is positive; The serum allergen-specific IgE antibody test results of 150 patients with digestive tract diseases and 150 healthy subjects in the control group were compared with the control group. The serum allergen-specific IgE antibody detection of 150 healthy persons in the control group was detected. Fruit and negative accounted for 87. 33%, specific IgE antibody concentration reached 1-2 level of 12.67%, specific Ig The serum allergen-specific IgE antibody test results of 150 patients in the patient group accounted for 42. 67%, the specific IgE antibody concentration reached 1-2 level (34.67%), the specific IgE antibody concentration reached Grade 3 (10.67%), the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration reached 3 levels. The positive rate of serum allergen-specific IgE antibody in 150 patients with digestive tract diseases was higher than that of control group 1. The positive rate of serum allergen-specific IgE antibody in 150 patients (57. 33%) was significantly higher than that in control group. In 50 healthy people (13.33%), the difference was different. There was statistical significance (P <0.05). Serum allergen-specific IgE antibody positive rate was the highest in patients with irritable bowel syndrome. The positive rates of serum allergen-specific IgE antibodies in patients with intestinal polyps and chronic gastritis were compared with those in control group. The positive rates of serum aspiration allergen-specific IgE antibodies in 150 patients with digestive tract diseases were compared with 150 healthy subjects in control group (P <0.05). The positive rate of anti-IgE antibody was significantly higher than that in the control group (P <0.05). The specific IgE antibody in the patient group A total of 150 patients with digestive tract diseases and 150 healthy subjects in the control group were compared with the control group. The positive rates of the specific IgE antibodies in serum were compared with those of 150 patients with digestive tract diseases. The positive rate of serum specific IgE antibody was significantly higher than that in the control group (P <0.05). The highest positive rate of human IgE antibody was crab. The positive rate of specific IgE antibody in serum of 150 patients with three digestive tract diseases showed that the positive rate of specific IgE antibody was 1-2 level, and the highest positive rate of allergen was the highest. In combination, the allergen with the highest positive rate at level 3 was the first group. At the level of level 1-2, the highest positive rate of allergen-specific IgE antibody was crab. Level 3, highest positive rate The positive rate of serum allergen-specific IgE antibody in patients with irritable bowel syndrome was compared: the positive rate of serum allergen-specific IgE antibody in patients with irritable bowel syndrome. The positive rate of serum allergen-specific IgE antibody in patients with chronic gastritis was significantly higher than that in patients with chronic gastritis (P <0.05).. 72%, serum allergen specific IgE antibody in female patients The positive rate was 57. 83%, and the difference was not statistically significant (P> 0.05). Conclusion: Patients with chronic gastritis, irritable bowel syndrome and intestinal polyp have higher serum allergen specific IgE antibody detection positive rate. The serum allergen-specific IgE antibody has the highest positive rate of detection positive rate, and the highest positive rate of the allergen-specific IgE antibody is the food-in allergen with the highest positive rate of detection, wherein the food-in allergen is crab, and the allergy factor is similar to the above-mentioned allergen.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R57
[Abstract]:Objective: To study the detection results of serum allergen-specific IgE antibody in patients with chronic gastritis, irritable bowel syndrome and intestinal polyp. Methods: 150 patients were selected from May 2012 to April 2014 in the First Affiliated Hospital of Dalian Medical University. 150 patients were diagnosed with chronic gastritis in 55 cases, irritable bowel syndrome in 35 cases, intestinal polyp 6. The diagnostic criteria for chronic gastritis were based on gastroscopy and pathological diagnosis, and the diagnosis of irritable bowel syndrome was based on the criteria of diagnosis of IBS, and the diagnosis of intestinal polyps was based on enteroscopy and biopsy of intestinal mucosa. Diagnosis: The control group was the healthy people in our hospital for the same period of 15 years. In 0 cases, 20 kinds of common allergen specific IgE antibody tests were carried out in patients with digestive tract diseases and healthy people by Western blot, and the correlation between allergic factors and the three kinds of digestive tract diseases was analyzed, and SPSS1.6. 0 software statistics were applied. Analysis. Results: There were 300 serum allergen-specific IgE antibody test results in 150 patients with digestive tract diseases and 150 healthy people in control group. The specific IgE antibody detection result of the combination of mold, egg white, peanut, soybean, beef, beef, fresh water fish, shrimp and crab is positive; the specific IgE antibody of the law grass, mutton and milk is positive; The serum allergen-specific IgE antibody test results of 150 patients with digestive tract diseases and 150 healthy subjects in the control group were compared with the control group. The serum allergen-specific IgE antibody detection of 150 healthy persons in the control group was detected. Fruit and negative accounted for 87. 33%, specific IgE antibody concentration reached 1-2 level of 12.67%, specific Ig The serum allergen-specific IgE antibody test results of 150 patients in the patient group accounted for 42. 67%, the specific IgE antibody concentration reached 1-2 level (34.67%), the specific IgE antibody concentration reached Grade 3 (10.67%), the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10. 67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration was 10.67%, the specific IgE antibody concentration reached 3 levels. The positive rate of serum allergen-specific IgE antibody in 150 patients with digestive tract diseases was higher than that of control group 1. The positive rate of serum allergen-specific IgE antibody in 150 patients (57. 33%) was significantly higher than that in control group. In 50 healthy people (13.33%), the difference was different. There was statistical significance (P <0.05). Serum allergen-specific IgE antibody positive rate was the highest in patients with irritable bowel syndrome. The positive rates of serum allergen-specific IgE antibodies in patients with intestinal polyps and chronic gastritis were compared with those in control group. The positive rates of serum aspiration allergen-specific IgE antibodies in 150 patients with digestive tract diseases were compared with 150 healthy subjects in control group (P <0.05). The positive rate of anti-IgE antibody was significantly higher than that in the control group (P <0.05). The specific IgE antibody in the patient group A total of 150 patients with digestive tract diseases and 150 healthy subjects in the control group were compared with the control group. The positive rates of the specific IgE antibodies in serum were compared with those of 150 patients with digestive tract diseases. The positive rate of serum specific IgE antibody was significantly higher than that in the control group (P <0.05). The highest positive rate of human IgE antibody was crab. The positive rate of specific IgE antibody in serum of 150 patients with three digestive tract diseases showed that the positive rate of specific IgE antibody was 1-2 level, and the highest positive rate of allergen was the highest. In combination, the allergen with the highest positive rate at level 3 was the first group. At the level of level 1-2, the highest positive rate of allergen-specific IgE antibody was crab. Level 3, highest positive rate The positive rate of serum allergen-specific IgE antibody in patients with irritable bowel syndrome was compared: the positive rate of serum allergen-specific IgE antibody in patients with irritable bowel syndrome. The positive rate of serum allergen-specific IgE antibody in patients with chronic gastritis was significantly higher than that in patients with chronic gastritis (P <0.05).. 72%, serum allergen specific IgE antibody in female patients The positive rate was 57. 83%, and the difference was not statistically significant (P> 0.05). Conclusion: Patients with chronic gastritis, irritable bowel syndrome and intestinal polyp have higher serum allergen specific IgE antibody detection positive rate. The serum allergen-specific IgE antibody has the highest positive rate of detection positive rate, and the highest positive rate of the allergen-specific IgE antibody is the food-in allergen with the highest positive rate of detection, wherein the food-in allergen is crab, and the allergy factor is similar to the above-mentioned allergen.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R57
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