【摘要】：目的探討血清降鈣素原(PCT)、血清淀粉樣蛋白A(SAA)、白細胞介素-8(IL-8)診斷肝硬化腹水感染的臨床價值研究,為肝硬化腹水感染的診斷提供參考。方法選取醫(yī)院2015年1月-2016年12月住院治療的肝硬化腹水患者100例,根據(jù)患者是否發(fā)生腹水感染分為感染組32例與無感染組68例,入院后穿刺抽取腹水進行細菌培養(yǎng),抽取外周靜脈血檢測血清PCT、SAA、IL-8。結(jié)果 100例患者腹水培養(yǎng)陽性32例,感染率32.00%,32例共培養(yǎng)出病原菌35株,其中革蘭陽性菌23株占65.71%,革蘭陰性菌12株占34.29%。感染組患者血清PCT、SAA、IL-8分別為(5.22±1.25)ng/ml、(35.51±8.12)mg/L、(18.49±3.40)pg/ml顯著高于無感染組(0.17±0.18)ng/ml、(4.19±0.27)mg/L、(10.20±2.34)pg/ml(P0.05);以腹水細菌培養(yǎng)陽性為金標準,血清PCT、SAA、IL-8用于診斷腹水感染的靈敏度分別為96.88%、93.75%、87.50%,特異度分別為88.24%、79.41%、82.35%,曲線下面積為0.924、0.912、0.903,準確率為91.00%、84.00%、84.00%。結(jié)論血清PCT、SAA、IL-8在肝硬化患者腹水感染時會出現(xiàn)升高,用于腹水感染的輔助診斷有較高的靈敏度及特異度,對臨床無明顯腹水感染癥狀的患者如存在血清PCT、SAA、IL-8的升高,建議進行早期干預(yù)治療。
[Abstract]:Objective to investigate the clinical value of serum procalcitonin (PCT), (PCT),) serum amyloid protein A (SAA), interleukin-8 (IL-8) in the diagnosis of ascites infection in cirrhotic patients. Methods from January 2015 to December 2016, 100 patients with ascites due to cirrhosis were divided into infection group (32 cases) and non-infected group (68 cases). Detection of serum PCT,SAA,IL-8. in peripheral venous blood samples Results among the 100 cases, 32 cases were positive in ascites culture, and the infection rate was 32.00%. 35 strains of pathogenic bacteria were cultured, of which 23 strains were Gram-positive bacteria (65.71%), 12 strains were Gram-negative bacteria (34.29%). 鎰熸煋緇勬?zhèn)ｈ�呰娓匬CT,SAA,IL-8鍒嗗埆涓，

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