【摘要】：目的:通過(guò)對(duì)比研究單用肝水解肽與肝水解肽聯(lián)合丹參川穹嗪對(duì)治療青海地區(qū)肝硬化患者的療效,明確二者有無(wú)統(tǒng)計(jì)學(xué)意義,從而更好地指導(dǎo)臨床用藥。方法:從2014年5月-2016年2月青海大學(xué)附屬醫(yī)院肝膽胰科確診并住院治療的肝硬化病人中選取30例作為A組,記錄其性別、年齡、族別及肝功能(Child-Pugh)分級(jí)等指標(biāo),作為配對(duì)條件。選取符合納入標(biāo)準(zhǔn)、排除標(biāo)準(zhǔn)以及滿足配對(duì)條件的肝硬化病人30例作為B組,確保能與A組30例嚴(yán)格配對(duì)。A組單用肝水解肽100mg,靜滴,1次/日,進(jìn)行治療,B組應(yīng)用肝水解肽100mg加丹參川穹嗪10ml,靜滴,1次/日進(jìn)行治療。分別觀察并記錄治療前、治療10天、治療20天后兩組所有肝硬化患者的肝功能生化指標(biāo)。用SPSS 17.0錄入數(shù)據(jù)并進(jìn)行統(tǒng)計(jì)學(xué)分析,由于該樣本量較小(30對(duì)),配對(duì)樣本差值經(jīng)正態(tài)性檢驗(yàn),不服從正態(tài)分布,呈偏態(tài)分布,故該資料用中位數(shù),四分位數(shù)間距即M,(QL-QU)表示,組間比較用秩和檢驗(yàn),以a=0.05為顯著性檢驗(yàn)水準(zhǔn)。結(jié)果:治療10天時(shí),經(jīng)秩和檢驗(yàn)五項(xiàng)指標(biāo)比較得出的Z值分別為:ALT,1.214;AST,0.508;ALP,1.080;GGT,0.463;CHE,1.512;P值分別為:ALT,0.225;AST,0.611;ALT,0.280;GGT,0.644;CHE,0.131。每項(xiàng)指標(biāo)P0.05。治療20天時(shí),經(jīng)秩和檢驗(yàn)五項(xiàng)指標(biāo)比較得出的Z值分別為:ALT,-2.220;AST,-0.035;ALP,-2.494;GGT,-2.403;CHE,-2.464;P值分別為:ALT,0.026;AST,0.738;ALT,0.013;GGT,0.016;CHE,0.008。其中,ALT、ALP、GGT、CHE指標(biāo)P0.05,AST指標(biāo)P0.05。結(jié)論:通過(guò)單用肝水解肽與肝水解肽聯(lián)合丹參川穹嗪對(duì)治療青海地區(qū)60例肝硬化患者的療效對(duì)比分析,在治療10天時(shí),兩組所觀察指標(biāo)無(wú)明顯差異,結(jié)果無(wú)統(tǒng)計(jì)學(xué)意義;在治療20天時(shí),兩組所觀察的五項(xiàng)指標(biāo)中有四項(xiàng)有明顯差異,結(jié)果有統(tǒng)計(jì)學(xué)意義,僅AST一項(xiàng)未見(jiàn)明顯差異,結(jié)果無(wú)統(tǒng)計(jì)學(xué)意義。
[Abstract]:Objective: to compare the efficacy of liver hydrolysate peptide and Danshen daizizine in the treatment of liver cirrhosis in Qinghai area, and to find out whether there is statistical significance between them. Methods: from May 2014 to February 2016, 30 patients with liver cirrhosis diagnosed and hospitalized in Department of Hepatobiliary Pancreatology, affiliated Hospital of Qinghai University were selected as group A, and their sex, age, ethnicity and Child-Pugh grading were recorded as matched conditions. Thirty cirrhotic patients who met the inclusion criteria, exclusion criteria and matching conditions were selected as group B to ensure that only 100 mg of hepatic hydrolysate was given intravenously to group A and 30 cases of group A were strictly matched. Group B was treated with liver hydrolysate peptide 100mg and danshen dachonosin 10 ml once a day. The biochemical indexes of liver function were observed and recorded before, 10 days and 20 days after treatment. The data were inputted by SPSS 17.0 and analyzed statistically. Because the sample size was small (30 pairs), the difference value of matched sample was tested by normality, and the data was skewed from normal distribution. Therefore, the data was represented by median, quartile spacing, I. E. M, (QL-QU). The rank sum test was used in the comparison between groups, with a significant test level of 0.05. Results: after 10 days of treatment, the Z values of the five indexes by rank sum test were as follows: 1: ALT 1.214A AST 0.508U ALPU 1.080 GGT0.463CHE1 512P = 0. 225m AST 0.611ALT0.280GGT0.644CHE 0.131. Each index (P0.05). After 20 days of treatment, the Z values compared with the five indexes of rank sum test were as follows: 1 / ALT ~ (-2.220) AST ~ (-0.035) ~ (-2.494) ~ (-2.404) GGT-2.404 ~ (th) Chem -2.464 (P = 0. 026) and 0. 738% ALT ~ (0.013) GGT ~ (0.016) Chem 0.008, respectively. The GGTCHE index P0.05and AST P0.05. Conclusion: there was no significant difference between the two groups in the treatment of 60 patients with liver cirrhosis in Qinghai area after 10 days of treatment, and there was no significant difference between the two groups. After 20 days of treatment, four of the five indexes observed in the two groups were significantly different, the results were statistically significant, only one item of AST had no significant difference, but the results were not statistically significant.
【學(xué)位授予單位】：青海大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R575.2

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